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Reprint of: MicroRNA profiling of human intermediate monocytes.
Zawada AM, Zhang L, Emrich IE, Rogacev KS, Krezdorn N, Rotter B, Fliser D, Devaux Y, Ziegler-Heitbrock L, Heine GH. Zawada AM, et al. Immunobiology. 2017 Jun;222(6):831-840. doi: 10.1016/j.imbio.2017.05.003. Epub 2017 May 31. Immunobiology. 2017. PMID: 28578934
To further substantiate the distinct role of intermediate monocytes within human monocyte heterogeneity, we assessed subset-specific expression of miRNAs as central epigenetic regulators of gene expression. We hypothesized that intermediate m
To further substantiate the distinct role of intermediate monocytes within human monocyte heterogeneity, we asse …
MicroRNA profiling of human intermediate monocytes.
Zawada AM, Zhang L, Emrich IE, Rogacev KS, Krezdorn N, Rotter B, Fliser D, Devaux Y, Ziegler-Heitbrock L, Heine GH. Zawada AM, et al. Immunobiology. 2017 Mar;222(3):587-596. doi: 10.1016/j.imbio.2016.11.006. Epub 2016 Nov 13. Immunobiology. 2017. PMID: 27876379
To further substantiate the distinct role of intermediate monocytes within human monocyte heterogeneity, we assessed subset-specific expression of miRNAs as central epigenetic regulators of gene expression. We hypothesized that intermediate m
To further substantiate the distinct role of intermediate monocytes within human monocyte heterogeneity, we asse …
Colorectal cancer-derived microvesicles modulate differentiation of human monocytes to macrophages.
Baj-Krzyworzeka M, Mytar B, Szatanek R, Surmiak M, Węglarczyk K, Baran J, Siedlar M. Baj-Krzyworzeka M, et al. J Transl Med. 2016 Feb 2;14:36. doi: 10.1186/s12967-016-0789-9. J Transl Med. 2016. PMID: 26838097 Free PMC article.
In the present study, the role of colon cancer cell-derived microvesicles in monocyte differentiation and activity profile (polarization) was investigated. ...RESULTS: Monocytes differentiated with TMVs exhibited morphological and phenotypical characteristics …
In the present study, the role of colon cancer cell-derived microvesicles in monocyte differentiation and activity profile (po …
INT-HA induces M2-like macrophage differentiation of human monocytes via TLR4-miR-935 pathway.
Zhang B, Du Y, He Y, Liu Y, Zhang G, Yang C, Gao F. Zhang B, et al. Cancer Immunol Immunother. 2019 Feb;68(2):189-200. doi: 10.1007/s00262-018-2261-6. Epub 2018 Oct 19. Cancer Immunol Immunother. 2019. PMID: 30341559
In our study, there was a negative correlation between plasma HA and miR-935 in monocytes from the peripheral blood of patients with solid tumors. There was also a negative correlation between miR-935 and M2-like macrophage markers in monocytes. These findings sugge …
In our study, there was a negative correlation between plasma HA and miR-935 in monocytes from the peripheral blood of patients with …
MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus.
Solé C, Domingo S, Ferrer B, Moliné T, Ordi-Ros J, Cortés-Hernández J. Solé C, et al. J Invest Dermatol. 2019 Jan;139(1):51-61. doi: 10.1016/j.jid.2018.07.026. Epub 2018 Aug 18. J Invest Dermatol. 2019. PMID: 30130620 Free article.
Among the DLE-specific microRNAs, we identified one keratinocyte-derived microRNA, miR-31, and one leukocyte-derived microRNA, miR-485-3p. ...Collectively, our findings suggest that overexpression of miR-31 and miR-485-p contribute to skin inflammation in DLE …
Among the DLE-specific microRNAs, we identified one keratinocyte-derived microRNA, miR-31, and one leukocyte-derived microR
Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis.
Ruiz-Limon P, Ortega-Castro R, Barbarroja N, Perez-Sanchez C, Jamin C, Patiño-Trives AM, Luque-Tevar M, Ibáñez-Costa A, Perez-Sanchez L, de la Rosa IA, Abalos-Aguilera M, Jimenez-Gomez Y, Calvo-Gutierrez J, Font P, Escudero-Contreras A, Alarcon-Riquelme ME, Collantes-Estevez E, López-Pedrera C; PRECISESADS Clinical Consortium and Flow Cytometry Study Group. Ruiz-Limon P, et al. Front Immunol. 2019 May 21;10:1111. doi: 10.3389/fimmu.2019.01111. eCollection 2019. Front Immunol. 2019. PMID: 31169830 Free PMC article.
Their transcriptomic profiles (mRNA and microRNA), proinflammatory patterns and activated pathways were evaluated and related to clinical features and CV risk. Mechanistic in vitro analyses were further performed. Results: CD14(++)CD16(+) intermediate mono
Their transcriptomic profiles (mRNA and microRNA), proinflammatory patterns and activated pathways were evaluated and related …
Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH. Kwee LC, et al. Physiol Genomics. 2019 Oct 1;51(10):506-515. doi: 10.1152/physiolgenomics.00033.2019. Epub 2019 Sep 18. Physiol Genomics. 2019. PMID: 31530226 Free PMC article. Clinical Trial.
We hypothesized that integration of dense microRNA (miRNA) profiling with biomarker measurements would highlight potential regulatory pathways that underlie the relationships between prognostic biomarkers, miRNAs, and cardiovascular phenotypes. ...NT-proBNP and OPN …
We hypothesized that integration of dense microRNA (miRNA) profiling with biomarker measurements would highlight potential reg …
CD16(+) monocytes give rise to CD103(+)RALDH2(+)TCF4(+) dendritic cells with unique transcriptional and immunological features.
Wacleche VS, Cattin A, Goulet JP, Gauchat D, Gosselin A, Cleret-Buhot A, Zhang Y, Tremblay CL, Routy JP, Ancuta P. Wacleche VS, et al. Blood Adv. 2018 Nov 13;2(21):2862-2878. doi: 10.1182/bloodadvances.2018020123. Blood Adv. 2018. PMID: 30381402 Free PMC article.
Classical CD16(-) vs intermediate/nonclassical CD16(+) monocytes differ in their homing potential and biological functions, but whether they differentiate into dendritic cells (DCs) with distinct contributions to immunity against bacterial/viral pathogens remains po …
Classical CD16(-) vs intermediate/nonclassical CD16(+) monocytes differ in their homing potential and biological functions, bu …
The relationships among monocyte subsets, miRNAs and inflammatory cytokines in patients with acute myocardial infarction.
Kazimierczyk E, Eljaszewicz A, Zembko P, Tarasiuk E, Rusak M, Kulczynska-Przybik A, Lukaszewicz-Zajac M, Kaminski K, Mroczko B, Szmitkowski M, Dabrowska M, Sobkowicz B, Moniuszko M, Tycinska A. Kazimierczyk E, et al. Pharmacol Rep. 2019 Feb;71(1):73-81. doi: 10.1016/j.pharep.2018.09.007. Epub 2018 Sep 12. Pharmacol Rep. 2019. PMID: 30481637
We aimed to investigate changes in the levels of cytokines (IL-6, TNF-alpha and IL-10), miRNAs profiles (miR-146 and miR-155) and distribution of different monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16++) in the acute and post-healing phases of AMI. METHODS: …
We aimed to investigate changes in the levels of cytokines (IL-6, TNF-alpha and IL-10), miRNAs profiles (miR-146 and miR-155) and dis …
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Jurkin J, Schichl YM, Koeffel R, Bauer T, Richter S, Konradi S, Gesslbauer B, Strobl H. Jurkin J, et al. J Immunol. 2010 May 1;184(9):4955-65. doi: 10.4049/jimmunol.0903021. Epub 2010 Apr 7. J Immunol. 2010. PMID: 20375304 Free article.
Using microarray profiling, we identified microRNA (miRNA) miR-146a to be constitutively expressed at higher levels in human LCs compared with intDCs. ...We identified miR-146a as a regulator of monocyte and DC activation but not myeloid/DC subset diff …
Using microarray profiling, we identified microRNA (miRNA) miR-146a to be constitutively expressed at higher levels in huma
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