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Modulation of microRNA processing by 5-lipoxygenase.
Uebbing S, Kreiß M, Scholl F, Häfner AK, Sürün D, Garscha U, Werz O, Basavarajappa D, Samuelsson B, Rådmark O, Suess B, Steinhilber D. Uebbing S, et al. FASEB J. 2021 Feb;35(2):e21193. doi: 10.1096/fj.202002108R. Epub 2020 Nov 17. FASEB J. 2021. PMID: 33205517
The miRNA biogenesis is tightly regulated to avoid dysfunction and consequent disease development. Here, we describe modulation of miRNA processing as a novel noncanonical function of the 5-lipoxygenase (5-LO) enzyme in monocytic cells. ...Our observat …
The miRNA biogenesis is tightly regulated to avoid dysfunction and consequent disease development. Here, we describe modulation of mi …
Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor.
Izzotti A, Balansky R, Micale RT, Pulliero A, La Maestra S, De Flora S. Izzotti A, et al. Carcinogenesis. 2020 Mar 13;41(1):91-99. doi: 10.1093/carcin/bgz158. Carcinogenesis. 2020. PMID: 31562745 Free PMC article.
Chronic inflammation plays a crucial role in the carcinogenesis process and, in particular, in smoking-related carcinogenesis. Therefore, anti-inflammatory agents provide an interesting perspective in the prevention of smoking-associated cancers. ...Moreover, the drug coun …
Chronic inflammation plays a crucial role in the carcinogenesis process and, in particular, in smoking-related carcinogenesis. Theref …
Regulation of genes in the arachidonic acid metabolic pathway by RNA processing and RNA-mediated mechanisms.
Lutz CS, Cornett AL. Lutz CS, et al. Wiley Interdiscip Rev RNA. 2013 Sep-Oct;4(5):593-605. doi: 10.1002/wrna.1183. Wiley Interdiscip Rev RNA. 2013. PMID: 23956046 Review.
Cyclooxygenase (COX) enzymes work in one arm of the pathway to produce prostaglandins (PGs) and thromboxanes (TXs), while the actions of 5-lipoxygenase (ALOX5 or 5LO) and its associated protein (ALOX5AP or FLAP) work in the other arm of the metabolic pathway to prod …
Cyclooxygenase (COX) enzymes work in one arm of the pathway to produce prostaglandins (PGs) and thromboxanes (TXs), while the actions of …
Long noncoding RNAs and their complex role in shaping and regulating arachidonic acid metabolism: Learning to love the (not-really) junk.
Desind SZ, Bell SK, Davidson ZM, Lutz CS. Desind SZ, et al. Wiley Interdiscip Rev RNA. 2023 Nov 23:e1828. doi: 10.1002/wrna.1828. Online ahead of print. Wiley Interdiscip Rev RNA. 2023. PMID: 37994271 Review.
Cyclooxygenase 2 (COX-2), the inducible, rate-limiting enzyme of the cyclooxygenase arm, produces two main forms of eicosanoids: prostaglandins and thromboxanes. AA metabolized through the lipoxygenase arm by the action of 5-lipoxygenase (ALOX5) produces eicosanoids …
Cyclooxygenase 2 (COX-2), the inducible, rate-limiting enzyme of the cyclooxygenase arm, produces two main forms of eicosanoids: prostagland …
Altering the Anti-inflammatory Lipoxin Microenvironment: a New Insight into Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis.
Chandrasekharan JA, Huang XM, Hwang AC, Sharma-Walia N. Chandrasekharan JA, et al. J Virol. 2016 Nov 28;90(24):11020-11031. doi: 10.1128/JVI.01491-16. Print 2016 Dec 15. J Virol. 2016. PMID: 27681120 Free PMC article.
Treating de novo KSHV-infected endothelial cells with lipoxin and epilipoxin creates an anti-inflammatory environment by decreasing the levels of NF-kappaB, AKT, ERK1/2, COX-2, and 5-lipoxygenase. Lipoxin treatment on CRISPR/CAS9 technology-mediated ALX/FPR gene del …
Treating de novo KSHV-infected endothelial cells with lipoxin and epilipoxin creates an anti-inflammatory environment by decreasing the leve …