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The Ontogeny of Monocyte Subsets.
Wolf AA, Yáñez A, Barman PK, Goodridge HS. Wolf AA, et al. Front Immunol. 2019 Jul 17;10:1642. doi: 10.3389/fimmu.2019.01642. eCollection 2019. Front Immunol. 2019. PMID: 31379841 Free PMC article. Review.
Recent studies have revealed previously unappreciated heterogeneity among monocytes that may explain this functional diversity, but our understanding of mechanisms controlling the functional programming of distinct monocyte subsets remains incomplete. ...Stud …
Recent studies have revealed previously unappreciated heterogeneity among monocytes that may explain this functional diversity, but o …
Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection.
Mily A, Kalsum S, Loreti MG, Rekha RS, Muvva JR, Lourda M, Brighenti S. Mily A, et al. J Vis Exp. 2020 Sep 18;(163). doi: 10.3791/61807. J Vis Exp. 2020. PMID: 33016941
We have established an experimental protocol to follow immune polarization of myeloid-derived cells into M1 (classically activated) or M2 (alternatively activated) macrophage-like cells through assessment with a 10-color flow cytometry panel that allows visualization and deep-cha …
We have established an experimental protocol to follow immune polarization of myeloid-derived cells into M1 (classically activated) or M2 (a …
Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX(3)CR1(+) Macrophages in Tissue Repair.
Zaid A, Tharmarajah K, Mostafavi H, Freitas JR, Sheng KC, Foo SS, Chen W, Vider J, Liu X, West NP, Herrero LJ, Taylor A, Mackay LK, Getts DR, King NJC, Mahalingam S. Zaid A, et al. mBio. 2020 Mar 3;11(2):e03353-19. doi: 10.1128/mBio.03353-19. mBio. 2020. PMID: 32127460 Free PMC article.
Selective modulation of CD11b(hi) Ly6C(hi) monocyte migration to infected muscle using immune-modifying microparticles (IMP) reduced disease score, tissue damage, and inflammation and promoted the accumulation of CX(3)CR1(+) macrophages, enhancing recovery an …
Selective modulation of CD11b(hi) Ly6C(hi) monocyte migration to infected muscle using immune-modifying microparticles (IMP) r …
Modulation of Monocyte Activation and Function during Direct Antiviral Agent Treatment in Patients Coinfected with HIV and Hepatitis C Virus.
De Pablo-Bernal RS, Jimenez-Leon MR, Tarancon-Diez L, Gutierrez-Valencia A, Serna-Gallego A, Trujillo-Rodriguez M, Alvarez-Rios AI, Milanes-Guisado Y, Espinosa N, Roca-Oporto C, Viciana P, Lopez-Cortes LF, Ruiz-Mateos E. De Pablo-Bernal RS, et al. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00773-20. doi: 10.1128/AAC.00773-20. Print 2020 Aug 20. Antimicrob Agents Chemother. 2020. PMID: 32571815 Free PMC article.
The activation phenotypes and functional changes in monocyte subsets during hepatitis C virus (HCV) elimination in HIV/HCV-coinfected patients were evaluated. ...The levels of the activation markers CD49d, CD40, and CX3CR1 were decreased after treatment in the mo
The activation phenotypes and functional changes in monocyte subsets during hepatitis C virus (HCV) elimination in HIV/HCV-coi …
Elevated Levels of Anti-Inflammatory Eicosanoids and Monocyte Heterogeneity in Mycobacterium tuberculosis Infection and Disease.
Nore KG, Jørgensen MJ, Dyrhol-Riise AM, Jenum S, Tonby K. Nore KG, et al. Front Immunol. 2020 Nov 12;11:579849. doi: 10.3389/fimmu.2020.579849. eCollection 2020. Front Immunol. 2020. PMID: 33304347 Free PMC article.
All monocyte subsets had low basal expression of COX-2 and 5-LOX, which were markedly increased upon PPD stimulation. ...In conclusion, the level of eicosanoids in plasma seem to vary between clinical states of Mtb infection. Mediators in the eicosanoid system are p …
All monocyte subsets had low basal expression of COX-2 and 5-LOX, which were markedly increased upon PPD stimulation. ...In co …
Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ.
Koscsó B, Kurapati S, Rodrigues RR, Nedjic J, Gowda K, Shin C, Soni C, Ashraf AZ, Purushothaman I, Palisoc M, Xu S, Sun H, Chodisetti SB, Lin E, Mack M, Kawasawa YI, He P, Rahman ZSM, Aifantis I, Shulzhenko N, Morgun A, Bogunovic M. Koscsó B, et al. Sci Immunol. 2020 Apr 10;5(46):eaax0062. doi: 10.1126/sciimmunol.aax0062. Sci Immunol. 2020. PMID: 32276965 Free PMC article.
Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the initiation of immune response and control of inflammation. ...Using mice we developed with a floxed Ccr7 allele, we showed that this local IgA …
Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the in …
Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting.
Santoro F, Pettini E, Kazmin D, Ciabattini A, Fiorino F, Gilfillan GD, Evenroed IM, Andersen P, Pozzi G, Medaglini D. Santoro F, et al. Front Immunol. 2018 Jun 5;9:1248. doi: 10.3389/fimmu.2018.01248. eCollection 2018. Front Immunol. 2018. PMID: 29922291 Free PMC article.
In particular, blood transcription modules related to innate immune response, such as monocyte and neutrophil recruitment, activation of antigen-presenting cells, and interferon response were activated. ...
In particular, blood transcription modules related to innate immune response, such as monocyte and neutrophil recruitment, activation …
Macrophage Polarization in Leprosy-HIV Co-infected Patients.
da Silva TP, Bittencourt TL, de Oliveira AL, Prata RBDS, Menezes V, Ferreira H, Nery JADC, de Oliveira EB, Sperandio da Silva GM, Sarno EN, Pinheiro RO. da Silva TP, et al. Front Immunol. 2020 Jul 29;11:1493. doi: 10.3389/fimmu.2020.01493. eCollection 2020. Front Immunol. 2020. PMID: 32849508 Free PMC article.
In leprosy, different tissue macrophage phenotypes have been associated with the different clinical forms of the disease, but it is not clear how HIV infection modulates the phenotype of innate immune cells (monocytes or macrophages) during leprosy. In the pr …
In leprosy, different tissue macrophage phenotypes have been associated with the different clinical forms of the disease, but it is n …
Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection.
Auger JP, Rivest S, Benoit-Biancamano MO, Segura M, Gottschalk M. Auger JP, et al. Infect Immun. 2020 Feb 20;88(3):e00787-19. doi: 10.1128/IAI.00787-19. Print 2020 Feb 20. Infect Immun. 2020. PMID: 31818962 Free PMC article.
Moreover, monocytes are composed of two main subsets: shorter-lived inflammatory monocytes and longer-lived patrolling monocytes. ...In contrast, the implication of patrolling monocytes was minimal throughout the S. suis infection. Conseq …
Moreover, monocytes are composed of two main subsets: shorter-lived inflammatory monocytes and longer-lived patrolling …
Human Dendritic Cells: Ontogeny and Their Subsets in Health and Disease.
Solano-Gálvez SG, Tovar-Torres SM, Tron-Gómez MS, Weiser-Smeke AE, Álvarez-Hernández DA, Franyuti-Kelly GA, Tapia-Moreno M, Ibarra A, Gutiérrez-Kobeh L, Vázquez-López R. Solano-Gálvez SG, et al. Med Sci (Basel). 2018 Oct 8;6(4):88. doi: 10.3390/medsci6040088. Med Sci (Basel). 2018. PMID: 30297662 Free PMC article. Review.
Dendritic cells are uniquely capable of attracting and activating naive CD4+ and CD8+ T cells to initiate and modulate primary immune responses. They have the ability to coordinate tolerance or immunity depending on their activation status, which is why they are also consi …
Dendritic cells are uniquely capable of attracting and activating naive CD4+ and CD8+ T cells to initiate and modulate primary immune …
70 results