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Monocyte-derived macrophages and myeloid cell lines as targets of HIV-1 replication and persistence.
Cassol E, Alfano M, Biswas P, Poli G. Cassol E, et al. J Leukoc Biol. 2006 Nov;80(5):1018-30. doi: 10.1189/jlb.0306150. Epub 2006 Aug 31. J Leukoc Biol. 2006. PMID: 16946020 Review.
Because the investigation of tissue macrophages is often very difficult for both ethical and practical reasons of accessibility, most studies of in vitro infection rely upon monocyte-derived macrophages (MDM), a methodology hampered by inter-patient va …
Because the investigation of tissue macrophages is often very difficult for both ethical and practical reasons of accessibility, most …
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.
Nasr N, Maddocks S, Turville SG, Harman AN, Woolger N, Helbig KJ, Wilkinson J, Bye CR, Wright TK, Rambukwelle D, Donaghy H, Beard MR, Cunningham AL. Nasr N, et al. Blood. 2012 Jul 26;120(4):778-88. doi: 10.1182/blood-2012-01-407395. Epub 2012 Jun 7. Blood. 2012. PMID: 22677126
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendriti
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimu
CD8+ T cell suppressor factors and the control of infection, replication and transcription of human immunodeficiency virus.
Copeland KF. Copeland KF. Arch Immunol Ther Exp (Warsz). 2001;49(1):13-8. Arch Immunol Ther Exp (Warsz). 2001. PMID: 11266085 Review.
However, another CD8+ T cell-derived factor(s) targets the replication of HIV-1 at the level of transcription. CD8+ T cell factors strongly suppress replication at the level of transcription in T cells and T …
However, another CD8+ T cell-derived factor(s) targets the replication of HIV-1 at the leve …
Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway.
Fernández Larrosa PN, Croci DO, Riva DA, Bibini M, Luzzi R, Saracco M, Mersich SE, Rabinovich GA, Martínez Peralta L. Fernández Larrosa PN, et al. Retrovirology. 2008 Feb 8;5:19. doi: 10.1186/1742-4690-5-19. Retrovirology. 2008. PMID: 18261236 Free PMC article.
BACKGROUND: HIV triggers the decline of CD4+ T cells and leads to progressive dysfunction of cell-mediated immunity. Although an increased susceptibility to cell death occurs during the acute phase of HIV infection, persistently-infected …
BACKGROUND: HIV triggers the decline of CD4+ T cells and leads to progressive dysfunction of cell-mediated immunity. Al …
HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages.
Gillim-Ross L, Cara A, Klotman ME. Gillim-Ross L, et al. Viral Immunol. 2005;18(1):190-6. doi: 10.1089/vim.2005.18.190. Viral Immunol. 2005. PMID: 15802963
In this study, the evaluation of the stability of cc2LTR was extended to include primary human macrophages, a natural, non-dividing target of HIV-1. ...This persistence was associated with persistent, low level expression of the indicator …
In this study, the evaluation of the stability of cc2LTR was extended to include primary human macrophages, a natural, non-dividing …
Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.
Kennedy PE, Bera TK, Wang QC, Gallo M, Wagner W, Lewis MG, Berger EA, Pastan I. Kennedy PE, et al. J Leukoc Biol. 2006 Nov;80(5):1175-82. doi: 10.1189/jlb.0306139. Epub 2006 Aug 21. J Leukoc Biol. 2006. PMID: 16923920
However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, leading invariably to viral rebound upon cessation of treatment. ...In the present report, we compare the in vitro potency and breadth of these chimeric toxi …
However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, leading invariabl …
Target cells for HIV in the central nervous system: macrophages or glial cells?
Erfle V, Stoeckbauer P, Kleinschmidt A, Kohleisen B, Mellert W, Stavrou D, Brack-Werner R. Erfle V, et al. Res Virol. 1991 Mar-Jun;142(2-3):139-44. doi: 10.1016/0923-2516(91)90050-d. Res Virol. 1991. PMID: 1896638
Infection of foetal or embryonic brain cells and cell lines from human astrocytomas and gliomas with HIV1 derived from T-lymphoma cultures leads to the expression of HIV in about 1 to 2% of the cells in culture. Single-cell
Infection of foetal or embryonic brain cells and cell lines from human astrocytomas and gliomas with HIV1 derived
vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus.
Chowdhury IH, Chao W, Potash MJ, Sova P, Gendelman HE, Volsky DJ. Chowdhury IH, et al. J Virol. 1996 Aug;70(8):5336-45. doi: 10.1128/JVI.70.8.5336-5345.1996. J Virol. 1996. PMID: 8764044 Free PMC article.
The vif gene of human immunodeficiency virus type 1 (HIV-1) is required for efficient infection of primary T lymphocytes. In this study, we investigated in detail the role of vif in productive infection of primary monocyte-derived macrophages
The vif gene of human immunodeficiency virus type 1 (HIV-1) is required for efficient infection of primary T lymphocyte …
The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.
Renga B, Francisci D, D'Amore C, Schiaroli E, Mencarelli A, Cipriani S, Baldelli F, Fiorucci S. Renga B, et al. PLoS One. 2012;7(4):e35924. doi: 10.1371/journal.pone.0035924. Epub 2012 Apr 30. PLoS One. 2012. PMID: 22558273 Free PMC article.
BACKGROUND: Long-term remission of HIV-1 disease can be readily achieved by combinations of highly effective antiretroviral therapy (HAART). ...Exposure of macrophage cell lines to p17 activates a signaling pathway mediated by Rack-1/Jak- …
BACKGROUND: Long-term remission of HIV-1 disease can be readily achieved by combinations of highly effective antiretrov …
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