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Monocyte-derived macrophages and myeloid cell lines as targets of HIV-1 replication and persistence.
Cassol E, Alfano M, Biswas P, Poli G. Cassol E, et al. J Leukoc Biol. 2006 Nov;80(5):1018-30. doi: 10.1189/jlb.0306150. Epub 2006 Aug 31. J Leukoc Biol. 2006. PMID: 16946020 Review.
Because the investigation of tissue macrophages is often very difficult for both ethical and practical reasons of accessibility, most studies of in vitro infection rely upon monocyte-derived macrophages (MDM), a methodology hampered by inter-patient va …
Because the investigation of tissue macrophages is often very difficult for both ethical and practical reasons of accessibility, most …
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.
Nasr N, Maddocks S, Turville SG, Harman AN, Woolger N, Helbig KJ, Wilkinson J, Bye CR, Wright TK, Rambukwelle D, Donaghy H, Beard MR, Cunningham AL. Nasr N, et al. Blood. 2012 Jul 26;120(4):778-88. doi: 10.1182/blood-2012-01-407395. Epub 2012 Jun 7. Blood. 2012. PMID: 22677126 Free article.
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendriti
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimu
CD8+ T cell suppressor factors and the control of infection, replication and transcription of human immunodeficiency virus.
Copeland KF. Copeland KF. Arch Immunol Ther Exp (Warsz). 2001;49(1):13-8. Arch Immunol Ther Exp (Warsz). 2001. PMID: 11266085 Review.
CD8+ T cells have been shown to produce factors which modulate HIV-1 replication in both T cells and monocytic cells. ...CD8+ T cell factors strongly suppress replication at the level of transcription in T cells and T …
CD8+ T cells have been shown to produce factors which modulate HIV-1 replication in both T cells and mono …
Macrophages derived from human induced pluripotent stem cells (iPSCs) serve as a high-fidelity cellular model for investigating HIV-1, dengue, and influenza viruses.
Yang Q, Barbachano-Guerrero A, Fairchild LM, Rowland TJ, Dowell RD, Allen MA, Warren CJ, Sawyer SL. Yang Q, et al. J Virol. 2024 Mar 19;98(3):e0156323. doi: 10.1128/jvi.01563-23. Epub 2024 Feb 7. J Virol. 2024. PMID: 38323811
We show that iPSC-derived macrophages support the replication of these viruses with kinetics and phenotypes similar to human blood monocyte-derived macrophages. ...Collectively, our results substantiate iPSC-derived macrophages
We show that iPSC-derived macrophages support the replication of these viruses with kinetics and phenotypes similar to …
HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages.
Gillim-Ross L, Cara A, Klotman ME. Gillim-Ross L, et al. Viral Immunol. 2005;18(1):190-6. doi: 10.1089/vim.2005.18.190. Viral Immunol. 2005. PMID: 15802963
HIV-1 extrachromosomal 2-LTR circles (cc2LTR) are rapidly lost in dividing cell populations and, therefore, might be interpreted as representing new infection and ongoing viral replication. ...These data suggest that the presence of HIV-1
HIV-1 extrachromosomal 2-LTR circles (cc2LTR) are rapidly lost in dividing cell populations and, therefore, might be in
Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway.
Fernández Larrosa PN, Croci DO, Riva DA, Bibini M, Luzzi R, Saracco M, Mersich SE, Rabinovich GA, Martínez Peralta L. Fernández Larrosa PN, et al. Retrovirology. 2008 Feb 8;5:19. doi: 10.1186/1742-4690-5-19. Retrovirology. 2008. PMID: 18261236 Free PMC article.
Although an increased susceptibility to cell death occurs during the acute phase of HIV infection, persistently-infected macrophages and quiescent T-cells seem to be resistant to cell death, representing a potential reservoir for virus productio …
Although an increased susceptibility to cell death occurs during the acute phase of HIV infection, persistently-infected ma
Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.
Kennedy PE, Bera TK, Wang QC, Gallo M, Wagner W, Lewis MG, Berger EA, Pastan I. Kennedy PE, et al. J Leukoc Biol. 2006 Nov;80(5):1175-82. doi: 10.1189/jlb.0306139. Epub 2006 Aug 21. J Leukoc Biol. 2006. PMID: 16923920
In the present report, we compare the in vitro potency and breadth of these chimeric toxins against multiple clinical HIV-1 isolates, replicating in biologically relevant primary human target cell types. In PBMCs, 3B3(Fv)-PE38 blocked spreading …
In the present report, we compare the in vitro potency and breadth of these chimeric toxins against multiple clinical HIV-1 is …
The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.
Renga B, Francisci D, D'Amore C, Schiaroli E, Mencarelli A, Cipriani S, Baldelli F, Fiorucci S. Renga B, et al. PLoS One. 2012;7(4):e35924. doi: 10.1371/journal.pone.0035924. Epub 2012 Apr 30. PLoS One. 2012. PMID: 22558273 Free PMC article.
BACKGROUND: Long-term remission of HIV-1 disease can be readily achieved by combinations of highly effective antiretroviral therapy (HAART). ...Exposure of macrophage cell lines to p17 activates a signaling pathway mediated by Rack-1/Jak-1/STAT-1 and c …
BACKGROUND: Long-term remission of HIV-1 disease can be readily achieved by combinations of highly effective antiretroviral th …
vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus.
Chowdhury IH, Chao W, Potash MJ, Sova P, Gendelman HE, Volsky DJ. Chowdhury IH, et al. J Virol. 1996 Aug;70(8):5336-45. doi: 10.1128/JVI.70.8.5336-5345.1996. J Virol. 1996. PMID: 8764044 Free PMC article.
Cell-free MDM-derived vif mutant HIV-1 was infectious in macrophages as determined by the synthesis and maintenance of full-length viral DNA and by the produc- tion of particle-associated viral RNA, but its infectivity was approximately 2
Cell-free MDM-derived vif mutant HIV-1 was infectious in macrophages as determined by the synthesis and m
Target cells for HIV in the central nervous system: macrophages or glial cells?
Erfle V, Stoeckbauer P, Kleinschmidt A, Kohleisen B, Mellert W, Stavrou D, Brack-Werner R. Erfle V, et al. Res Virol. 1991 Mar-Jun;142(2-3):139-44. doi: 10.1016/0923-2516(91)90050-d. Res Virol. 1991. PMID: 1896638
Infection of foetal or embryonic brain cells and cell lines from human astrocytomas and gliomas with HIV1 derived from T-lymphoma cultures leads to the expression of HIV in about 1 to 2% of the cells in culture. Single-cell cloning of ast …
Infection of foetal or embryonic brain cells and cell lines from human astrocytomas and gliomas with HIV1 derived