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Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease.
França CN, Izar MCO, Hortêncio MNS, do Amaral JB, Ferreira CES, Tuleta ID, Fonseca FAH. França CN, et al. Clin Sci (Lond). 2017 Jun 1;131(12):1215-1224. doi: 10.1042/CS20170009. Clin Sci (Lond). 2017. PMID: 28566450 Review.
Many studies in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This re …
Many studies in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor
CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke.
Faustino J, Chip S, Derugin N, Jullienne A, Hamer M, Haddad E, Butovsky O, Obenaus A, Vexler ZS. Faustino J, et al. J Cereb Blood Flow Metab. 2019 Oct;39(10):1919-1935. doi: 10.1177/0271678X18817663. Epub 2019 Jan 10. J Cereb Blood Flow Metab. 2019. PMID: 30628839
Unique identifiers of microglia and monocytes revealed phenotypic changes in each cell subtype of the monocyte lineage after CAIS. Taken together, CX3CR1-CCR2-dependent microglia-monocyte signaling contributes to cerebrovascular leakage, inflamm …
Unique identifiers of microglia and monocytes revealed phenotypic changes in each cell subtype of the monocyte lineage …
Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain.
Garcia-Bonilla L, Faraco G, Moore J, Murphy M, Racchumi G, Srinivasan J, Brea D, Iadecola C, Anrather J. Garcia-Bonilla L, et al. J Neuroinflammation. 2016 Nov 4;13(1):285. doi: 10.1186/s12974-016-0750-0. J Neuroinflammation. 2016. PMID: 27814740 Free PMC article.
There are two main monocyte subsets in the mouse blood: CCR2(+)Ly6C(hi) "inflammatory" monocytes involved in acute inflammation, and CX3CR1(+)Ly6C(lo) "patrolling" monocytes, which may play a role in repair processes. ...These findings provide new insi …
There are two main monocyte subsets in the mouse blood: CCR2(+)Ly6C(hi) "inflammatory" monocytes involved in acute infl …
Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation.
Miró-Mur F, Pérez-de-Puig I, Ferrer-Ferrer M, Urra X, Justicia C, Chamorro A, Planas AM. Miró-Mur F, et al. Brain Behav Immun. 2016 Mar;53:18-33. doi: 10.1016/j.bbi.2015.08.010. Epub 2015 Aug 12. Brain Behav Immun. 2016. PMID: 26275369
However, monocytes are a heterogeneous population of cells with different functions. Herein, we investigated the infiltration and fate of the monocyte subsets in a mouse model of focal brain ischemia by permanent occlusion of the distal portion of the middle cerebra …
However, monocytes are a heterogeneous population of cells with different functions. Herein, we investigated the infiltration and fat …
Choroidal Neovascularization Is Inhibited in Splenic-Denervated or Splenectomized Mice with a Concomitant Decrease in Intraocular Macrophage.
Tan X, Fujiu K, Manabe I, Nishida J, Yamagishi R, Terashima Y, Matsushima K, Kaburaki T, Nagai R, Yanagi Y. Tan X, et al. PLoS One. 2016 Aug 17;11(8):e0160985. doi: 10.1371/journal.pone.0160985. eCollection 2016. PLoS One. 2016. PMID: 27532664 Free PMC article.
Further, we evaluated the lesion size in mice administered the β3 receptor antagonist, splenic-denervated and splenectomized mice. ...In contrast, Ly6Cint/loCD64+ subtype showed a significantly higher percentage at day 7 after laser injury. There were no differences …
Further, we evaluated the lesion size in mice administered the β3 receptor antagonist, splenic-denervated and splenectomized mice. .. …
Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis.
Leib C, Göser S, Lüthje D, Öttl R, Tretter T, Lasitschka F, Zittrich S, Pfitzer G, Katus HA, Kaya Z. Leib C, et al. Circ Res. 2011 Jul 8;109(2):130-40. doi: 10.1161/CIRCRESAHA.111.245563. Epub 2011 May 19. Circ Res. 2011. PMID: 21597011
OBJECTIVE: Chemical stimulation of the efferent arm of the vagus nerve through activation of nicotinic acetylcholine receptor subtype-7α (α7-nAChR) has been shown to be protective in several models of inflammatory diseases. ...Furthermore, elevated levels of …
OBJECTIVE: Chemical stimulation of the efferent arm of the vagus nerve through activation of nicotinic acetylcholine receptor subt
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