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201 results

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6 articles found by citation matching
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Page 1
Monocytes and macrophages in abdominal aortic aneurysm.
Raffort J, Lareyre F, Clément M, Hassen-Khodja R, Chinetti G, Mallat Z. Raffort J, et al. Nat Rev Cardiol. 2017 Aug;14(8):457-471. doi: 10.1038/nrcardio.2017.52. Epub 2017 Apr 13. Nat Rev Cardiol. 2017. PMID: 28406184 Review.
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity, and high mortality in the event of aortic rupture. ...The inflammatory process has a crucial role in AAA and substantially influences many determinants of …
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity, and high mortality in the …
Single-cell RNA sequencing identifies interferon-inducible monocytes/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk.
Le S, Wu J, Liu H, Du Y, Wang D, Luo J, Yang P, Ran S, Hu P, Chen M, Ye P, Xia J. Le S, et al. Cardiovasc Res. 2024 Sep 21;120(11):1351-1364. doi: 10.1093/cvr/cvae117. Cardiovasc Res. 2024. PMID: 38836630
AIMS: Abdominal aortic aneurysm (AAA) represents a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. ...Mechanistically, the activated pyroptosis- and inflammation-related signalling pathways, regulated by IR …
AIMS: Abdominal aortic aneurysm (AAA) represents a life-threatening condition characterized by medial layer degeneratio …
Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation.
Thayaparan D, Emoto T, Khan AB, Besla R, Hamidzada H, El-Maklizi M, Sivasubramaniyam T, Vohra S, Hagerman A, Nejat S, Needham-Robbins CE, Wang T, Lindquist M, Botts SR, Schroer SA, Taniguchi M, Inoue T, Yamanaka K, Cui H, Al-Chami E, Zhang H, Althagafi MG, Michalski A, McGrath JJC, Cass SP, Luong D, Suzuki Y, Li A, Abow A, Heo R, Pacheco S, Chen E, Chiu F, Byrne J, Furuyashiki T, Husain M, Libby P, Okada K, Howe KL, Heximer SP, Yamashita T, Wang B, Rubin BB, Cybulsky MI, Roy J, Williams JW, Crome SQ, Epelman S, Hirata KI, Stampfli MR, Robbins CS. Thayaparan D, et al. Nat Immunol. 2025 May;26(5):706-721. doi: 10.1038/s41590-025-02132-8. Epub 2025 Apr 22. Nat Immunol. 2025. PMID: 40263614
Single-nucleus RNA sequencing revealed that cigarette smoke-induced endothelial cell dysfunction promoted monocyte recruitment and inflammatory signaling and amplified vascular injury. Furthermore, single-cell transcriptomic analysis identified conserved macrophage …
Single-nucleus RNA sequencing revealed that cigarette smoke-induced endothelial cell dysfunction promoted monocyte recruitment and in …
Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms.
Davis FM, Tsoi LC, Ma F, Wasikowski R, Moore BB, Kunkel SL, Gudjonsson JE, Gallagher KA. Davis FM, et al. Ann Surg. 2022 Sep 1;276(3):511-521. doi: 10.1097/SLA.0000000000005551. Epub 2022 Jun 28. Ann Surg. 2022. PMID: 35762613 Free PMC article.
OBJECTIVE: To determine cell-specific gene expression profiles that contribute to development of abdominal aortic aneurysms (AAAs). BACKGROUND: AAAs represent the most common pathological aortic dilation leading to the fatal consequence of aortic ruptu …
OBJECTIVE: To determine cell-specific gene expression profiles that contribute to development of abdominal aortic aneurysms (A …
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.
Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu C, Moore BB, Kunkel SL, Daugherty A, Lu HS, Gudjonsson JE, Gallagher KA. Davis FM, et al. J Exp Med. 2021 Jun 7;218(6):e20201839. doi: 10.1084/jem.20201839. J Exp Med. 2021. PMID: 33779682 Free PMC article.
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. ...Recent evidence suggests that an epigenetic enzyme, JMJD3, plays a critical role in establishing macrophage ph …
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing …
Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta.
Zhao G, Lu H, Chang Z, Zhao Y, Zhu T, Chang L, Guo Y, Garcia-Barrio MT, Chen YE, Zhang J. Zhao G, et al. Cardiovasc Res. 2021 Apr 23;117(5):1402-1416. doi: 10.1093/cvr/cvaa214. Cardiovasc Res. 2021. PMID: 32678909 Free PMC article.
However, the heterogeneity and cellular responses of these vascular cells during abdominal aortic aneurysm (AAA) progression have not been well characterized. METHODS AND RESULTS: Single-cell RNA sequencing was performed on the infrarenal abdominal aor …
However, the heterogeneity and cellular responses of these vascular cells during abdominal aortic aneurysm (AAA) progre …
ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm.
Cai D, Sun C, Murashita T, Que X, Chen SY. Cai D, et al. Circ Res. 2023 Feb 17;132(4):e78-e93. doi: 10.1161/CIRCRESAHA.122.321722. Epub 2023 Jan 23. Circ Res. 2023. PMID: 36688311 Free PMC article.
BACKGROUND: Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA) development. ...The relevance of macrophage ADAR1 to human AAA was examined using human aneurysm specimens. Moreover, a novel humanized AAA model w …
BACKGROUND: Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA) development. ...The r …
GSDME-dependent pyroptosis drives abdominal aortic aneurysm via promoting vascular senescence.
Sun SJ, Zhang Z, Zhang GY, Wu JJ, Zhang YX, Wu WB, Zhang Y, Yin H, Zhang JB, Cao Q, Wu JW, Shen FM, Zhou J, Li DJ, Wang P. Sun SJ, et al. Nat Commun. 2025 Dec 17;16(1):11248. doi: 10.1038/s41467-025-66103-1. Nat Commun. 2025. PMID: 41407670 Free PMC article.
Senescence contributes to the pathology of abdominal aortic aneurysm (AAA); however, the regulation of senescence in AAA remains unclear. ...Combined analyses of single-cell RNA sequencing (scRNA-seq), bulk RNA-seq, and multiplex flow cytometry demonstrate th …
Senescence contributes to the pathology of abdominal aortic aneurysm (AAA); however, the regulation of senescence in AA …
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.
Vandestienne M, Zhang Y, Santos-Zas I, Al-Rifai R, Joffre J, Giraud A, Laurans L, Esposito B, Pinet F, Bruneval P, Raffort J, Lareyre F, Vilar J, Boufenzer A, Guyonnet L, Guerin C, Clauser E, Silvestre JS, Lang S, Soulat-Dufour L, Tedgui A, Mallat Z, Taleb S, Boissonnas A, Derive M, Chinetti G, Ait-Oufella H. Vandestienne M, et al. J Clin Invest. 2021 Jan 19;131(2):e142468. doi: 10.1172/JCI142468. J Clin Invest. 2021. PMID: 33258804 Free PMC article.
The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the role of TREM-1 in a mouse model of …
The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role …
Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm.
Potteaux S, Tedgui A. Potteaux S, et al. Curr Pharm Des. 2015;21(28):4007-15. doi: 10.2174/1381612821666150826093855. Curr Pharm Des. 2015. PMID: 26306839 Review.
Macrophages early invade the forming abdominal aortic aneurysm (AAA) and greatly contribute to its pathogenesis. ...The first wave of Ly-6C(high) monocytes prevails in the aorta and promotes the accumulation of inflammatory macrophages, w …
Macrophages early invade the forming abdominal aortic aneurysm (AAA) and greatly contribute to its pathogenesis. …
201 results