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Mycobacterial growth inhibition is associated with trained innate immunity.
Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH. Joosten SA, et al. J Clin Invest. 2018 May 1;128(5):1837-1851. doi: 10.1172/JCI97508. Epub 2018 Apr 3. J Clin Invest. 2018. PMID: 29461976 Free PMC article.
Cytokines previously associated with trained immunity were detected in MGIA supernatants, and CXCL9, CXCL10, and CXCL11 represent new markers of trained immunity. These data indicate that CXCR3 ligands are associated with trained
Cytokines previously associated with trained immunity were detected in MGIA supernatants, and CXCL9, CXCL10, and CXCL11 …
RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice.
Prabowo SA, Painter H, Zelmer A, Smith SG, Seifert K, Amat M, Cardona PJ, Fletcher HA. Prabowo SA, et al. Front Immunol. 2019 Apr 30;10:894. doi: 10.3389/fimmu.2019.00894. eCollection 2019. Front Immunol. 2019. PMID: 31114572 Free PMC article.
We found an association between the peak response of vaccine-induced growth inhibition and a shift in monocyte phenotype following RUTI vaccination in healthy mice. ...On the other hand, the impact of RUTI on non-classical monocytes could also reflect its imp …
We found an association between the peak response of vaccine-induced growth inhibition and a shift in monocyte phenotyp …
β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.
Moorlag SJCFM, Khan N, Novakovic B, Kaufmann E, Jansen T, van Crevel R, Divangahi M, Netea MG. Moorlag SJCFM, et al. Cell Rep. 2020 May 19;31(7):107634. doi: 10.1016/j.celrep.2020.107634. Cell Rep. 2020. PMID: 32433977 Free PMC article.
β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained immunity," resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exposure confers protecti …
β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained i
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