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Mycobacterial growth inhibition is associated with trained innate immunity.
Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH. Joosten SA, et al. J Clin Invest. 2018 May 1;128(5):1837-1851. doi: 10.1172/JCI97508. Epub 2018 Apr 3. J Clin Invest. 2018. PMID: 29461976 Free PMC article.
Cytokines previously associated with trained immunity were detected in MGIA supernatants, and CXCL9, CXCL10, and CXCL11 represent new markers of trained immunity. These data indicate that CXCR3 ligands are associated with trained
Cytokines previously associated with trained immunity were detected in MGIA supernatants, and CXCL9, CXCL10, and CXCL11 …
beta-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.
Moorlag SJCFM, Khan N, Novakovic B, Kaufmann E, Jansen T, van Crevel R, Divangahi M, Netea MG. Moorlag SJCFM, et al. Cell Rep. 2020 May 19;31(7):107634. doi: 10.1016/j.celrep.2020.107634. Cell Rep. 2020. PMID: 32433977 Free PMC article.
beta-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained immunity," resulting in an enhanced host response against secondary infections. We investigate whether beta-glucan exposure confers pr …
beta-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained
RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice.
Prabowo SA, Painter H, Zelmer A, Smith SG, Seifert K, Amat M, Cardona PJ, Fletcher HA. Prabowo SA, et al. Front Immunol. 2019 Apr 30;10:894. doi: 10.3389/fimmu.2019.00894. eCollection 2019. Front Immunol. 2019. PMID: 31114572 Free PMC article.
In the absence of a validated correlate of vaccine-induced protection for TB vaccine testing, mycobacterial growth inhibition assay (MGIA) has been developed as a comprehensive tool to evaluate vaccine potency ex vivo. ...We found an association betwee …
In the absence of a validated correlate of vaccine-induced protection for TB vaccine testing, mycobacterial growth inhibiti