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Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome.
Kim AJ, Xu N, Umeyama K, Hulin A, Ponny SR, Vagnozzi RJ, Green EA, Hanson P, McManus BM, Nagashima H, Yutzey KE. Kim AJ, et al. Circulation. 2020 Jan 14;141(2):132-146. doi: 10.1161/CIRCULATIONAHA.119.042391. Epub 2020 Jan 13. Circulation. 2020. PMID: 31928435 Free PMC article.
Additional histological and transcriptomic evaluation was performed by using nonsyndromic human and canine myxomatous valves, respectively. Macrophage ontogeny was determined using MFS mice transplanted with mTomato+ bone marrow or MFS mice harboring RFP (red fluorescent …
Additional histological and transcriptomic evaluation was performed by using nonsyndromic human and canine myxomatous valves, respectively. …
Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
Shami A, Atzler D, Bosmans LA, Winkels H, Meiler S, Lacy M, van Tiel C, Ta Megens R, Nitz K, Baardman J, Kusters P, Seijkens T, Buerger C, Janjic A, Riccardi C, Edsfeldt A, Monaco C, Daemen M, de Winther MPJ, Nilsson J, Weber C, Gerdes N, Gonçalves I, Lutgens E. Shami A, et al. Eur Heart J. 2020 Aug 14;41(31):2938-2948. doi: 10.1093/eurheartj/ehaa484. Eur Heart J. 2020. PMID: 32728688
As atherosclerosis bears features of chronic inflammation and autoimmunity, we investigated the relevance of GITR in cardiovascular disease (CVD). ...RNA sequencing of Gitr-/-Apoe-/- and Apoe-/- monocytes and macrophages revealed altered pathway …
As atherosclerosis bears features of chronic inflammation and autoimmunity, we investigated the relevance of GITR in cardiovascula
Novel insight from the first lung transplant of a COVID-19 patient.
Chen XJ, Li K, Xu L, Yu YJ, Wu B, He YL, Zhao WE, Li D, Luan CX, Hu L, Wang J, Ding JJ, Yu YF, Li JX, Tan ZM, Liu XF, Wei D, Zhang ZH, Guo XJ, Su C, Hu ZB, Guo YS, Chen JY, Chen F. Chen XJ, et al. Eur J Clin Invest. 2021 Jan;51(1):e13443. doi: 10.1111/eci.13443. Epub 2020 Nov 20. Eur J Clin Invest. 2021. PMID: 33131070
BACKGROUND: To reveal detailed histopathological changes, virus distributions, immunologic properties and multi-omic features caused by SARS-CoV-2 in the explanted lungs from the world's first successful lung transplantation of a COVID-19 patient. ...CONCLUSIONS: Ou …
BACKGROUND: To reveal detailed histopathological changes, virus distributions, immunologic properties and multi-omic features caused …
High-Resolution Regulatory Maps Connect Vascular Risk Variants to Disease-Related Pathways.
Åkerborg Ö, Spalinskas R, Pradhananga S, Anil A, Höjer P, Poujade FA, Folkersen L, Eriksson PP, Sahlén P. Åkerborg Ö, et al. Circ Genom Precis Med. 2019 Mar;12(3):e002353. doi: 10.1161/CIRCGEN.118.002353. Circ Genom Precis Med. 2019. PMID: 30786239
It is crucial to assign the genetic variants to their correct genes both to gain insights into perturbed functions and better assess the risk of disease. METHODS: In this study, we generated high-resolution genomic interaction maps (750 bases) in aortic endothelial, smooth …
It is crucial to assign the genetic variants to their correct genes both to gain insights into perturbed functions and better assess the ris …
Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction.
Nguyen HN, Ahn YJ, Medina EA, Asmis R. Nguyen HN, et al. Atherosclerosis. 2018 Aug;275:333-341. doi: 10.1016/j.atherosclerosis.2018.06.882. Epub 2018 Jun 27. Atherosclerosis. 2018. PMID: 30015296 Free PMC article.
METHODS: We performed chemotaxis assays to determine IC(50) of phytochemicals on primed THP-1 monocytes. We fed 12-week old female LDLR(-/-) mice a high-fat diet (HFD) or a HFD supplemented with either 0.05% UA or 0.05% 23-OHUA, and measured monocyte priming, weight …
METHODS: We performed chemotaxis assays to determine IC(50) of phytochemicals on primed THP-1 monocytes. We fed 12-week old female LD …
Adipose tissue dysregulation in patients with metabolic syndrome.
Bremer AA, Devaraj S, Afify A, Jialal I. Bremer AA, et al. J Clin Endocrinol Metab. 2011 Nov;96(11):E1782-8. doi: 10.1210/jc.2011-1577. Epub 2011 Aug 24. J Clin Endocrinol Metab. 2011. PMID: 21865369 Free PMC article.
CONTEXT: The metabolic syndrome (MetS) is associated with increased risk of diabetes and cardiovascular disease (CVD). Numerous groups have shown increased circulating biomarkers of inflammation in MetS. ...In SAT, leptin, RBP-4, CRP, serum amyloid A, plasminogen ac …
CONTEXT: The metabolic syndrome (MetS) is associated with increased risk of diabetes and cardiovascular disease (CVD). Numerou …
Neutrophil elastase in human atherosclerotic plaques: production by macrophages.
Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Dollery CM, et al. Circulation. 2003 Jun 10;107(22):2829-36. doi: 10.1161/01.CIR.0000072792.65250.4A. Epub 2003 May 27. Circulation. 2003. PMID: 12771009
Freshly isolated blood monocytes, monocyte-derived macrophages, and vascular endothelial cells in culture produced active NE and contained NE mRNA. ...CONCLUSIONS: These findings point to a novel role for the serine protease, neutrophil elastase, in ma …
Freshly isolated blood monocytes, monocyte-derived macrophages, and vascular endothelial cells in culture produced acti …