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1995 1
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PU.1 (Spi-1) autoregulates its expression in myeloid cells.
Chen H, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zhang DE, Moreau-Gachelin F, Tenen DG. Chen H, et al. Oncogene. 1995 Oct 19;11(8):1549-60. Oncogene. 1995. PMID: 7478579
PU.1 (Spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid (granulocytes, monocytes and macrophages) and B cells. ...Positive autoregulation of the PU.1 promoter may pl
PU.1 (Spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid
Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis.
Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I. Giladi A, et al. Nat Cell Biol. 2018 Jul;20(7):836-846. doi: 10.1038/s41556-018-0121-4. Epub 2018 Jun 18. Nat Cell Biol. 2018. PMID: 29915358
We define the signature of the naive haematopoietic stem cell and find a continuum of core progenitor states. Core cell populations mix transcription of pre-myeloid and pre-lymphoid programs, but do not mix erythroid or megakaryocyte programs with other fates. CRISP-seq pe …
We define the signature of the naive haematopoietic stem cell and find a continuum of core progenitor states. Core cell populations mix tran …
Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.
Zhang DE, Hohaus S, Voso MT, Chen HM, Smith LT, Hetherington CJ, Tenen DG. Zhang DE, et al. Curr Top Microbiol Immunol. 1996;211:137-47. doi: 10.1007/978-3-642-85232-9_14. Curr Top Microbiol Immunol. 1996. PMID: 8585944 Review.
Similarly, expression of PU.1 activates its own promoter, and turns on the three myeloid CSF receptors (M, GM, and G), pushing these cells along the pathway of myeloid differentiation. ...Myeloid genes expressed later during …
Similarly, expression of PU.1 activates its own promoter, and turns on the three myeloid CSF receptors (M, GM, a …
PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.
Rustenhoven J, Smith AM, Smyth LC, Jansson D, Scotter EL, Swanson MEV, Aalderink M, Coppieters N, Narayan P, Handley R, Overall C, Park TIH, Schweder P, Heppner P, Curtis MA, Faull RLM, Dragunow M. Rustenhoven J, et al. Mol Neurodegener. 2018 Aug 20;13(1):44. doi: 10.1186/s13024-018-0277-1. Mol Neurodegener. 2018. PMID: 30124174 Free PMC article.
The transcription factor PU.1 is critical in the development of myeloid cells and a major regulator of microglial gene expression. ...Lastly, we demonstrate that several of these PU.1-regulated genes are expressed by …
The transcription factor PU.1 is critical in the development of myeloid cells and a major regulator of microglia …
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosammam AM, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F. Leddin M, et al. Blood. 2011 Mar 10;117(10):2827-38. doi: 10.1182/blood-2010-08-302976. Epub 2011 Jan 14. Blood. 2011. PMID: 21239694 Free PMC article.
The transcription factor PU.1 occupies a central role in controlling myeloid and early B-cell development, and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. ...We previously identified …
The transcription factor PU.1 occupies a central role in controlling myeloid and early B-cell development, and its corr …
Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.
Samaniego R, Domínguez-Soto Á, Ratnam M, Matsuyama T, Sánchez-Mateos P, Corbí ÁL, Puig-Kröger A. Samaniego R, et al. Cells. 2020 Jun 10;9(6):1445. doi: 10.3390/cells9061445. Cells. 2020. PMID: 32532019 Free PMC article.
The functional relevance of PU.1 binding was demonstrated through analysis of the proximal regulatory region of the FOLR2 gene, whose activity was dependent on a cluster of PU.1-binding sequences. Further, siRNA-mediated knockdown established th …
The functional relevance of PU.1 binding was demonstrated through analysis of the proximal regulatory region of the FOLR2 g
Temporal autoregulation during human PU.1 locus SubTAD formation.
Schuetzmann D, Walter C, van Riel B, Kruse S, König T, Erdmann T, Tönges A, Bindels E, Weilemann A, Gebhard C, Wethmar K, Perrod C, Minderjahn J, Rehli M, Delwel R, Lenz G, Gröschel S, Dugas M, Rosenbauer F. Schuetzmann D, et al. Blood. 2018 Dec 20;132(25):2643-2655. doi: 10.1182/blood-2018-02-834721. Epub 2018 Oct 12. Blood. 2018. PMID: 30315124 Free article.
We identified a dynamic 75-kb unit (SubTAD) as the genomic region in which spatial interactions between PU.1 gene regulatory elements occur during myeloid differentiation and are interrupted in AML. ...However, once these spatial interactions have occu …
We identified a dynamic 75-kb unit (SubTAD) as the genomic region in which spatial interactions between PU.1 gene regul …
Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks.
Chopin M, Seillet C, Chevrier S, Wu L, Wang H, Morse HC 3rd, Belz GT, Nutt SL. Chopin M, et al. J Exp Med. 2013 Dec 16;210(13):2967-80. doi: 10.1084/jem.20130930. Epub 2013 Nov 18. J Exp Med. 2013. PMID: 24249112 Free PMC article.
PU.1 controls LC differentiation by regulating the expression of the critical TGF-beta responsive transcription factor RUNX3. PU.1 directly binds to the Runx3 regulatory elements in a TGF-beta-dependent manner, whereas ectopic expression
PU.1 controls LC differentiation by regulating the expression of the critical TGF-beta responsive transcription factor
Positive feedback between PU.1 and the cell cycle controls myeloid differentiation.
Kueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV. Kueh HY, et al. Science. 2013 Aug 9;341(6146):670-3. doi: 10.1126/science.1240831. Epub 2013 Jul 18. Science. 2013. PMID: 23868921 Free PMC article.
Here, we dissect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid differentiation. Quantitative live-cell imaging revealed that developing B cells decrease PU.1 levels by reducing PU. …
Here, we dissect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid differen …
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ, Schroeder T. Hoppe PS, et al. Nature. 2016 Jul 14;535(7611):299-302. doi: 10.1038/nature18320. Nature. 2016. PMID: 27411635
Here we use novel reporter mouse lines and live imaging for continuous single-cell long-term quantification of the transcription factors GATA1 and PU.1 (also known as SPI1). We analyse individual haematopoietic stem cells throughout differentiation into megak …
Here we use novel reporter mouse lines and live imaging for continuous single-cell long-term quantification of the transcription factors GAT …
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