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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 1
1983 5
1984 2
1985 3
1986 3
1987 2
1988 4
1989 2
1990 2
1991 5
1992 1
1993 3
1994 7
1995 2
1996 4
1997 2
1998 5
1999 11
2000 12
2001 11
2002 8
2003 11
2004 15
2005 13
2006 18
2007 23
2008 27
2009 27
2010 28
2011 26
2012 32
2013 29
2014 33
2015 33
2016 46
2017 46
2018 41
2019 32
2020 12
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The Immune Escape Mechanisms of Mycobacterium Tuberculosis.
Zhai W, Wu F, Zhang Y, Fu Y, Liu Z. Zhai W, et al. Int J Mol Sci. 2019 Jan 15;20(2):340. doi: 10.3390/ijms20020340. Int J Mol Sci. 2019. PMID: 30650615 Free PMC article. Review.
Mycobacterium tuberculosis (MTB) is an intracellular parasite that mainly attacks macrophages and inhibits their apoptosis. It can become a long-term infection in humans, causing a series of pathological changes and clinical manifestations. In this review, we summar …
Mycobacterium tuberculosis (MTB) is an intracellular parasite that mainly attacks macrophages and inhibits their apoptosis. It can be …
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo.
Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA. Lee JH, et al. Autophagy. 2019 Mar;15(3):543-557. doi: 10.1080/15548627.2018.1528812. Epub 2018 Oct 26. Autophagy. 2019. PMID: 30269645 Free PMC article.
Furthermore, using a third fluorescence label in TRGL6 brains to identify lysosomes by immunocytochemistry, we validated a novel procedure to detect defective autolysosomal acidification in vivo. ...Abbreviations: ACTB: actin, beta; AD: Alzheimer disease; AL: autolysosomes …
Furthermore, using a third fluorescence label in TRGL6 brains to identify lysosomes by immunocytochemistry, we validated a novel procedure t …
Macrophage defense mechanisms against intracellular bacteria.
Weiss G, Schaible UE. Weiss G, et al. Immunol Rev. 2015 Mar;264(1):182-203. doi: 10.1111/imr.12266. Immunol Rev. 2015. PMID: 25703560 Free PMC article. Review.
These include induction of toxic anti-microbial effectors such as nitric oxide and reactive oxygen intermediates, the stimulation of microbe intoxication mechanisms via acidification or metal accumulation in the phagolysosome, the restriction of the microbe's access …
These include induction of toxic anti-microbial effectors such as nitric oxide and reactive oxygen intermediates, the stimulation of microbe …
The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.
Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. Sedlyarov V, et al. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. Cell Host Microbe. 2018. PMID: 29779931 Free PMC article.
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. ...Loss of SLC4A7 reduced acidification of phagocytosed beads or bacteria and impaired the intracellular mi …
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in p …
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosère N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P. Queval CJ, et al. Cell Rep. 2017 Sep 26;20(13):3188-3198. doi: 10.1016/j.celrep.2017.08.101. Cell Rep. 2017. PMID: 28954234 Free PMC article.
In the case of Mycobacterium tuberculosis, it has been shown that regulation of phagosome acidification could be achieved by interfering with the retention of the V-ATPase complexes at the vacuole. Here, we present evidence that M. tuberculosis resorts to yet anothe …
In the case of Mycobacterium tuberculosis, it has been shown that regulation of phagosome acidification could be achieved by i …
Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage.
Huang L, Nazarova EV, Russell DG. Huang L, et al. Microbiol Spectr. 2019 Mar;7(2):10.1128/microbiolspec.BAI-0001-2019. doi: 10.1128/microbiolspec.BAI-0001-2019. Microbiol Spectr. 2019. PMID: 30848232 Free PMC article. Review.
The pathogen spends most of its infection cycle in its human host within a phagocyte. The bacterium has evolved to block the normal maturation and acidification of its phagosome and resides in a vacuole contiguous with the early endosomal network. ...Tissue-r …
The pathogen spends most of its infection cycle in its human host within a phagocyte. The bacterium has evolved to block the normal m …
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB. Buter J, et al. Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19. Nat Chem Biol. 2019. PMID: 31427817
Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. ...Although macrophages kill intracellular bacteria through …
Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosiny …
Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.
Sasaki T, Lian S, Khan A, Llop JR, Samuelson AV, Chen W, Klionsky DJ, Kishi S. Sasaki T, et al. Autophagy. 2017 Feb;13(2):386-403. doi: 10.1080/15548627.2016.1256934. Epub 2016 Nov 22. Autophagy. 2017. PMID: 27875093 Free PMC article.
Our data suggest that Spns1 and the v-ATPase orchestrate proper autolysosomal biogenesis with optimal acidification that is critically linked to developmental senescence and survival....
Our data suggest that Spns1 and the v-ATPase orchestrate proper autolysosomal biogenesis with optimal acidification that is criticall …
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion.
Mauvezin C, Neufeld TP. Mauvezin C, et al. Autophagy. 2015;11(8):1437-8. doi: 10.1080/15548627.2015.1066957. Autophagy. 2015. PMID: 26156798 Free PMC article.
We recently revisited the role of lysosomal acidification in autophagosome-lysosome fusion, using an in vivo approach in Drosophila. ...In contrast, bafilomycin A1 inhibited both acidification and fusion, consistent with its effects in mammalian cells. Together, the …
We recently revisited the role of lysosomal acidification in autophagosome-lysosome fusion, using an in vivo approach in Drosophila. …
Microbial co-infection alters macrophage polarization, phagosomal escape, and microbial killing.
Trivedi NH, Yu JJ, Hung CY, Doelger RP, Navara CS, Armitige LY, Seshu J, Sinai AP, Chambers JP, Guentzel MN, Arulanandam BP. Trivedi NH, et al. Innate Immun. 2018 Apr;24(3):152-162. doi: 10.1177/1753425918760180. Epub 2018 Feb 26. Innate Immun. 2018. PMID: 29482417 Free PMC article.
In response to multi-bacterial infection, the macrophage activation state may change upon exposure to nascent mediators, which results in different bacterial killing mechanism(s). ...BCG infection had little effect on LVS escape from phagosomes into the cytosol in M …
In response to multi-bacterial infection, the macrophage activation state may change upon exposure to nascent mediators, which results in di …
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