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Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function.
Dickinson JL, Bates EJ, Ferrante A, Antalis TM. Dickinson JL, et al. J Biol Chem. 1995 Nov 17;270(46):27894-904. doi: 10.1074/jbc.270.46.27894. J Biol Chem. 1995. PMID: 7499264 Free article.
Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin that is a major product of macrophages in response to endotoxin and inflammatory cytokines. We have explored the role of PAI-2 in apop
Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin t
Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression.
Dear AE, Shen Y, Rüegg M, Medcalf RL. Dear AE, et al. Eur J Biochem. 1996 Oct 1;241(1):93-100. doi: 10.1111/j.1432-1033.1996.0093t.x. Eur J Biochem. 1996. PMID: 8898893 Free article.
Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the regulation of urokinase-dependent proteolysis, is also implicated in the inhibition of tumor-necrosis-factor-(T
Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the
The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis.
Dickinson JL, Norris BJ, Jensen PH, Antalis TM. Dickinson JL, et al. Cell Death Differ. 1998 Feb;5(2):163-71. doi: 10.1038/sj.cdd.4400324. Cell Death Differ. 1998. PMID: 10200461 Free article.
The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), has been reported to inhibit tumor necrosis factor-alpha (TNF) induced apoptosis. ...The PAI …
The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), h …
The serine proteinase inhibitor (serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming.
Antalis TM, La Linn M, Donnan K, Mateo L, Gardner J, Dickinson JL, Buttigieg K, Suhrbier A. Antalis TM, et al. J Exp Med. 1998 Jun 1;187(11):1799-811. doi: 10.1084/jem.187.11.1799. J Exp Med. 1998. PMID: 9607921 Free PMC article.
The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is well characterized as an inhibitor of extracellular urokinase-type plasminogen activator. ...PAI-2 was al …
The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is …
Crebanine, an aporphine alkaloid, sensitizes TNF-α-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-κB-regulated gene products.
Yodkeeree S, Pompimon W, Limtrakul P. Yodkeeree S, et al. Tumour Biol. 2014 Sep;35(9):8615-24. doi: 10.1007/s13277-014-1998-6. Epub 2014 May 28. Tumour Biol. 2014. PMID: 24867094
In this study, we investigated the effects of crebanine on tumor necrosis factor alpha (TNF-α)-induced NF-κB activation and the expression of NF-κB-regulated gene products. ...Moreover, crebanine reduced TNF-α-induced A549 cell invasion a …
In this study, we investigated the effects of crebanine on tumor necrosis factor alpha (TNF-α)-induced NF …
Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system.
Abdullah Z, Bayraktutan U. Abdullah Z, et al. Biochim Biophys Acta. 2016 Jul;1862(7):1354-66. doi: 10.1016/j.bbadis.2016.03.014. Epub 2016 Apr 17. Biochim Biophys Acta. 2016. PMID: 27094771 Free article.
Treatment of HBMEC with TNF-α significantly increased the mRNA and protein expressions of all plasminogen-plasmin system (PPS) components, namely tissue plasminogen activator, urokinase, urokinase plasminogen activator receptor and plasminoge
Treatment of HBMEC with TNF-α significantly increased the mRNA and protein expressions of all plasminogen-plasmin system (PPS) compon …
Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells.
Jänicke RU, Lee FH, Porter AG. Jänicke RU, et al. Mol Cell Biol. 1994 Sep;14(9):5661-70. doi: 10.1128/mcb.14.9.5661. Mol Cell Biol. 1994. PMID: 8065303 Free PMC article.
Northern (RNA) blot analyses showed that there were no significant differences between these cell lines in basal or TNF-alpha-induced mRNA expression for a variety of proteins, including manganous superoxide dismutase, A20 zinc finger protein, plasminogen
Northern (RNA) blot analyses showed that there were no significant differences between these cell lines in basal or TNF-alpha-indu
Is interferon gamma one key of metastatic potential increase in human bladder carcinoma?
Champelovier P, Simon A, Garrel C, Levacher G, Praloran V, Seigneurin D. Champelovier P, et al. Clin Cancer Res. 2003 Oct 1;9(12):4562-9. Clin Cancer Res. 2003. PMID: 14555531 Free article.
RESULTS: IFN-gamma (>5 ng.ml(-1))(>400 IU.ml(-1)) inhibited the growth of bladder cancer cell lines and modified the expression of the tumor-associated markers tissue-type plasminogen activators, Plasminogen activator inhibitor
RESULTS: IFN-gamma (>5 ng.ml(-1))(>400 IU.ml(-1)) inhibited the growth of bladder cancer cell lines and modified the expression …
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