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Plasminogen activator inhibitor type 2 inhibitors tumor necrosis factor a induced apoptosis
(20 results)?
Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function.
J Biol Chem. 1995 Nov 17;270(46):27894-904. doi: 10.1074/jbc.270.46.27894.
J Biol Chem. 1995.
PMID: 7499264
Free article.
Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin that is a major product of macrophages in response to endotoxin and inflammatory cytokines. We have explored the role of PAI-2 in apop …
Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin t …
The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis.
Cell Death Differ. 1998 Feb;5(2):163-71. doi: 10.1038/sj.cdd.4400324.
Cell Death Differ. 1998.
PMID: 10200461
The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), has been reported to inhibit tumor necrosis factor-alpha (TNF) induced apoptosis. ...The PAI …
The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), h …
Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression.
Eur J Biochem. 1996 Oct 1;241(1):93-100. doi: 10.1111/j.1432-1033.1996.0093t.x.
Eur J Biochem. 1996.
PMID: 8898893
Free article.
Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the regulation of urokinase-dependent proteolysis, is also implicated in the inhibition of tumor-necrosis-factor-(T …
Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the …
CTSS Modulates Stress-Related Carotid Artery Thrombosis in a Mouse FeCl3 Model.
Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e238-e253. doi: 10.1161/ATVBAHA.122.318455. Epub 2023 Apr 27.
Arterioscler Thromb Vasc Biol. 2023.
PMID: 37128920
BACKGROUND: Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. ...Compared to the nonstressed CTSS(+/+) mice, the stressed CTSS(-/-) mice had decreased levels of PAI-1, vWF, TNF (tumor necrosis factor …
BACKGROUND: Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. ...Compared to the …
Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis.
Thromb Res. 2021 Sep 23;207:85-95. doi: 10.1016/j.thromres.2021.09.014. Online ahead of print.
Thromb Res. 2021.
PMID: 34583153
Free article.
Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of plasminogen activator inhibitor type 1 (PAI-1), thrombin-antithrombin (TAT), D-dimer, fibrinogen(Fib), tumor necrosis factor-alpha (TNF-alp …
Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of plasminogen activator inhibitor ty …
The serine proteinase inhibitor (serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming.
J Exp Med. 1998 Jun 1;187(11):1799-811. doi: 10.1084/jem.187.11.1799.
J Exp Med. 1998.
PMID: 9607921
Free PMC article.
The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is well characterized as an inhibitor of extracellular urokinase-type plasminogen activator. ...These observations, …
The serine proteinase inhibitor (serpin) plasminogen activator inhibitor type 2 (PAI-2) is …
Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells.
Mol Cell Biol. 1994 Sep;14(9):5661-70. doi: 10.1128/mcb.14.9.5661-5670.1994.
Mol Cell Biol. 1994.
PMID: 8065303
Free PMC article.
The phosphoprotein c-Myc has the potential to kill cells by apoptosis. To investigate whether c-Myc is involved in tumor necrosis factor alpha (TNF-alpha)-mediated cell killing, we have examined two HeLa cell lines (D98 and H21) which sho …
The phosphoprotein c-Myc has the potential to kill cells by apoptosis. To investigate whether c-Myc is involved in tumor ne …
Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis.
Pharmacol Res. 2022 Oct;184:106424. doi: 10.1016/j.phrs.2022.106424. Epub 2022 Sep 5.
Pharmacol Res. 2022.
PMID: 36064077
Free PMC article.
NRICM102 was found to disrupt spike protein/ACE2 interaction, 3CL protease activity, reduce activation of neutrophils, monocytes and expression of cytokines (TNF-alpha, IL-1beta, IL-6, IL-8), chemokines (MCP-1, MIP-1, RANTES) and proinflammatory receptor (TLR4). NRICM102 a …
NRICM102 was found to disrupt spike protein/ACE2 interaction, 3CL protease activity, reduce activation of neutrophils, monocytes and express …
Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system.
Biochim Biophys Acta. 2016 Jul;1862(7):1354-66. doi: 10.1016/j.bbadis.2016.03.014. Epub 2016 Apr 17.
Biochim Biophys Acta. 2016.
PMID: 27094771
Free article.
Using an in vitro model of human blood-brain barrier (BBB) composed of brain microvascular endothelial cells (HBMEC) and astrocytes, this study assessed the putative roles of these elements in BBB damage evoked by enhanced availability of pro-inflammatory cytokine, TNF-alpha …
Using an in vitro model of human blood-brain barrier (BBB) composed of brain microvascular endothelial cells (HBMEC) and astrocytes, this st …
Crebanine, an aporphine alkaloid, sensitizes TNF-α-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-κB-regulated gene products.
Tumour Biol. 2014 Sep;35(9):8615-24. doi: 10.1007/s13277-014-1998-6. Epub 2014 May 28.
Tumour Biol. 2014.
PMID: 24867094
In this study, we investigated the effects of crebanine on tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activation and the expression of NF-kappaB-regulated gene products. ...Moreover, crebanine reduced TNF-alpha-in …
In this study, we investigated the effects of crebanine on tumor necrosis factor alpha (TNF-alpha)-ind …
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