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Proinflammatory properties of the human S100 protein S100A12.
Yang Z, Tao T, Raftery MJ, Youssef P, Di Girolamo N, Geczy CL. Yang Z, et al. J Leukoc Biol. 2001 Jun;69(6):986-94. J Leukoc Biol. 2001. PMID: 11404386
S100 proteins represent a new class of chemoattractants. Here we extend earlier evidence for the proinflammatory properties of human S100A12. ...
S100 proteins represent a new class of chemoattractants. Here we extend earlier evidence for the proinflammatory pro …
S100 Calgranulins in inflammatory arthritis.
Perera C, McNeil HP, Geczy CL. Perera C, et al. Immunol Cell Biol. 2010 Jan;88(1):41-9. doi: 10.1038/icb.2009.88. Epub 2009 Nov 24. Immunol Cell Biol. 2010. PMID: 19935766 Review.
Calgranulins comprise three proteins, S100A8 (Calgranulin A), S100A9 (Calgranulin B) and S100A12 (Calgranulin C) that are predominantly expressed by neutrophils, monocytes and activated macrophages. These S100 calcium-binding proteins are important mol …
Calgranulins comprise three proteins, S100A8 (Calgranulin A), S100A9 (Calgranulin B) and S100A12 (Calgranulin C) that are pred …
Inflammation-associated S100 proteins: new mechanisms that regulate function.
Goyette J, Geczy CL. Goyette J, et al. Amino Acids. 2011 Oct;41(4):821-42. doi: 10.1007/s00726-010-0528-0. Epub 2010 Mar 6. Amino Acids. 2011. PMID: 20213444 Review.
S100A8-SNO suppresses mast cell activation and inflammation in the microcirculation and may act as an NO transporter to regulate vessel tone in inflammatory lesions. S100A12 activates mast cells and is a monocyte and mast cell chemoattractant; a G-protein-coupled me …
S100A8-SNO suppresses mast cell activation and inflammation in the microcirculation and may act as an NO transporter to regulate vessel tone …
Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases.
Malengier-Devlies B, Metzemaekers M, Gouwy M, Van Nieuwenhove E, Betrains A, Cockx M, Vanbrabant L, Pörtner N, Vercauteren J, De Somer L, Struyf S, Vanderschueren S, De Langhe E, Proost P, Matthys P, Wouters C. Malengier-Devlies B, et al. J Clin Immunol. 2021 Jul;41(5):1072-1084. doi: 10.1007/s10875-021-01008-4. Epub 2021 Mar 5. J Clin Immunol. 2021. PMID: 33666778
The phenotypical features, degranulation properties, and phagocytic capacity of neutrophils were assessed by flow cytometry. Production of reactive oxygen species (ROS), myeloperoxidase (MPO) release, and chemotactic responses were investigated via chemiluminescence, ELISA …
The phenotypical features, degranulation properties, and phagocytic capacity of neutrophils were assessed by flow cytometry. Producti …
Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease.
Foell D, Kucharzik T, Kraft M, Vogl T, Sorg C, Domschke W, Roth J. Foell D, et al. Gut. 2003 Jun;52(6):847-53. doi: 10.1136/gut.52.6.847. Gut. 2003. PMID: 12740341 Free PMC article.
BACKGROUND: Intestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC) is characterised by an influx of neutrophils into the intestinal mucosa. S100A12 is a calcium binding protein with proinflammatory properties. It is secreted by act …
BACKGROUND: Intestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC) is characterised by an influx of neutrophils into th …
S100A12 suppresses pro-inflammatory, but not pro-thrombotic functions of serum amyloid A.
Chung YM, Goyette J, Tedla N, Hsu K, Geczy CL. Chung YM, et al. PLoS One. 2013 Apr 24;8(4):e62372. doi: 10.1371/journal.pone.0062372. Print 2013. PLoS One. 2013. PMID: 23638054 Free PMC article.
Serum amyloid A induces monocyte cytokines and tissue factor. S100A12 did not stimulate IL-6, IL-8, IL-1beta or TNF-alpha production by human peripheral blood mononuclear cells but low amounts consistently reduced cytokine mRNA and protein levels induced by s …
Serum amyloid A induces monocyte cytokines and tissue factor. S100A12 did not stimulate IL-6, IL-8, IL-1beta or TNF-alpha production …
Serum calgranulin C as a non-invasive predictor of activity among inflammatory bowel disease.
Rasmy HS, Elnakeeb NA, Mohamed MF, Elbaz HS. Rasmy HS, et al. Egypt J Immunol. 2024 Jul;31(3):81-94. Egypt J Immunol. 2024. PMID: 38995671
Therefore, non-invasive biomarkers are needed for early diagnosis and follow up to avoid the complications of invasive diagnostic procedures. Calgranulin C is a calcium binding protein with proinflammatory properties. The aim of this study was to evaluate the …
Therefore, non-invasive biomarkers are needed for early diagnosis and follow up to avoid the complications of invasive diagnostic procedures …