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Prostacyclin analogs suppress the synthesis of tumor necrosis factor-alpha in LPS-stimulated human peripheral blood mononuclear cells.
Eisenhut T, Sinha B, Gröttrup-Wolfers E, Semmler J, Siess W, Endres S. Eisenhut T, et al. Immunopharmacology. 1993 Nov-Dec;26(3):259-64. doi: 10.1016/0162-3109(93)90042-o. Immunopharmacology. 1993. PMID: 7507098
Recent reports have shown that prostaglandin E2 (PGE2) is able to suppress lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-alpha (TNF-alpha). In the present study we compared PGE2 with prostacyclin
Recent reports have shown that prostaglandin E2 (PGE2) is able to suppress lipopolysaccharide (LPS)-stimulated producti …
Prostaglandin I2 analogs suppress tumor necrosis factor alpha production and the maturation of human monocyte-derived dendritic cells.
Yeh CH, Kuo CH, Yang SN, Huang MY, Wu HC, Wang HP, Kuo TH, Hung CH. Yeh CH, et al. J Investig Med. 2011 Oct;59(7):1109-15. doi: 10.2310/JIM.0b013e3182281f62. J Investig Med. 2011. PMID: 21716128
METHODS: Human MDDCs were pretreated with iloprost and treprostinil (2 PGI2 analogs) or forskolin (an adenyl cyclase activator) before lipopolysaccharide (LPS) stimulation. In some cases, I prostanoid (IP) receptor and E prostanoid receptor antagonists …
METHODS: Human MDDCs were pretreated with iloprost and treprostinil (2 PGI2 analogs) or forskolin (an adenyl cyclase activator …
Prostaglandin I(2) analogues suppress TNF-alpha expression in human monocytes via mitogen-activated protein kinase pathway.
Wang WL, Kuo CH, Chu YT, Huang CH, Lam KP, Huang SK, Jong YJ, Kuo YT, Hung CH. Wang WL, et al. Inflamm Res. 2011 Jul;60(7):655-63. doi: 10.1007/s00011-011-0317-6. Epub 2011 Mar 13. Inflamm Res. 2011. PMID: 21400214
Intracellular signaling was investigated by Western blot. RESULTS: PGI(2) analogues suppressed LPS-induced TNF-alpha expression in THP-1 cells. ...CONCLUSION: PGI(2) analogues suppressed LPS-induced TNF-alpha expressi …
Intracellular signaling was investigated by Western blot. RESULTS: PGI(2) analogues suppressed LPS-induced TNF-alpha
Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids.
Sinha B, Semmler J, Eisenhut T, Eigler A, Endres S. Sinha B, et al. Eur J Immunol. 1995 Jan;25(1):147-53. doi: 10.1002/eji.1830250125. Eur J Immunol. 1995. PMID: 7843225
We investigated cooperative effects of phosphodiesterase (PDE) inhibitors and prostanoids on cyclic adenosine monophosphate (cAMP) accumulation and tumor necrosis factor (TNF)-alpha synthesis in human peripheral blood mon
We investigated cooperative effects of phosphodiesterase (PDE) inhibitors and prostanoids on cyclic adenosine monophosphate (cAMP) accumulat …
Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production.
Eigler A, Siegmund B, Emmerich U, Baumann KH, Hartmann G, Endres S. Eigler A, et al. J Leukoc Biol. 1998 Jan;63(1):101-7. doi: 10.1002/jlb.63.1.101. J Leukoc Biol. 1998. PMID: 9469479
Interleukin-10 (IL-10) and tumor necrosis factor (TNF) exert key roles in some acute and chronic inflammatory diseases. ...Human peripheral blood mononuclear cells were stimulated with lipopolysaccharide (LPS). …
Interleukin-10 (IL-10) and tumor necrosis factor (TNF) exert key roles in some acute and chronic inflammatory diseases. …