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Prostaglandin E(2) and tumour necrosis factor-alpha release by monocytes are modulated by phospholipids.
Morris RH, Price AJ, Tonks A, Jackson SK, Jones KP. Morris RH, et al. Cytokine. 2000 Nov;12(11):1717-9. doi: 10.1006/cyto.2000.0762. Cytokine. 2000. PMID: 11052824
This study investigates the effect of alveolar surfactant lipids on the regulation of tumour necrosis factor alpha (TNF-alpha), a potent inflammatory cytokine, and prostaglandin E(2)(PGE(2)), a lipid mediator with anti-inflammatory proper …
This study investigates the effect of alveolar surfactant lipids on the regulation of tumour necrosis factor alpha
Reactive oxygen species as glomerular autacoids.
Baud L, Fouqueray B, Philippe C, Ardaillou R. Baud L, et al. J Am Soc Nephrol. 1992 Apr;2(10 Suppl):S132-8. doi: 10.1681/ASN.V210s132. J Am Soc Nephrol. 1992. PMID: 1600128 Review.
They involve direct and indirect injury to resident cells (mesangiolysis) and glomerular basement membrane (in concert with metalloproteases) and alteration of both the release and binding of vasoactive substances, such as bioactive lipids (e.g., prostaglandin E2
They involve direct and indirect injury to resident cells (mesangiolysis) and glomerular basement membrane (in concert with metalloproteases …
Modulation of TNFalpha, IL-10 and IL-12p40 levels by a ceramide-1-phosphate analog, PCERA-1, in vivo and ex vivo in primary macrophages.
Avni D, Goldsmith M, Ernst O, Mashiach R, Tuntland T, Meijler MM, Gray NS, Rosen H, Zor T. Avni D, et al. Immunol Lett. 2009 Mar 24;123(1):1-8. doi: 10.1016/j.imlet.2008.12.011. Epub 2009 Jan 29. Immunol Lett. 2009. PMID: 19185589
Phospho-ceramide analog-1 (PCERA-1) has been described as a potent in vivo suppressor of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha), and thus as a putative drug for the treatment of inflammatory diseases. ...Finally, we show t …
Phospho-ceramide analog-1 (PCERA-1) has been described as a potent in vivo suppressor of the pro-inflammatory cytokine tumor necro