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Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors.
Selinger M, Věchtová P, Tykalová H, Ošlejšková P, Rumlová M, Štěrba J, Grubhoffer L. Selinger M, et al. Comput Struct Biotechnol J. 2022 May 30;20:2759-2777. doi: 10.1016/j.csbj.2022.05.052. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35685361 Free PMC article.
Thus, we performed a comprehensive analysis of alterations in host poly-(A)/miRNA/lncRNA expression upon TBEV infection in vitro in human primary neurons (high cytopathic effect) and astrocytes (low cytopathic effect). ...Candidate mechanisms responsible for the afo …
Thus, we performed a comprehensive analysis of alterations in host poly-(A)/miRNA/lncRNA expression upon TBEV infection in vit …
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, Zhou J, Lu X, Zhang L, Chen Z, Zhang Q, Chen Q, Zuo D. Liu Y, et al. J Exp Clin Cancer Res. 2023 Feb 1;42(1):38. doi: 10.1186/s13046-023-02609-0. J Exp Clin Cancer Res. 2023. PMID: 36721234 Free PMC article.
This study sought to identify the new target that is involved in inflammation-related liver tumorigenesis. METHODS: RNA-sequencing (RNA-seq) analysis was performed to identify the differential gene expression signature in primary human hepatocytes treated wit …
This study sought to identify the new target that is involved in inflammation-related liver tumorigenesis. METHODS: RNA-sequencing (RNA-seq) …
Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases.
Scarafia LE, Winter A, Swinney DC. Scarafia LE, et al. Physiol Genomics. 2000 Dec 18;4(2):147-153. doi: 10.1152/physiolgenomics.2000.4.2.147. Physiol Genomics. 2000. PMID: 11120875
We evaluated the expression of 28 gene sequences with homology to the carboxy terminal of HECT E3 ubiquitin ligases in nine human cell lines using RT-PCR, to determine whether gene expression could be associated with cell- …
We evaluated the expression of 28 gene sequences with homology to the carboxy terminal of HECT E3 ubiquitin
NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T, Yang Y. Li M, et al. Cell Death Dis. 2019 Aug 19;10(9):628. doi: 10.1038/s41419-019-1843-3. Cell Death Dis. 2019. PMID: 31427565 Free PMC article.
Here, we find that NudCL2 is required for accurate centriole duplication by stabilizing the E3 ligase HECT domain and RCC1-like domain-containing protein 2 (HERC2). ...Overexpression of NudCL2 significantly suppresses hydroxyurea-induced …
Here, we find that NudCL2 is required for accurate centriole duplication by stabilizing the E3 ligase HECT domain
Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.
An CI, Ganio E, Hagiwara N. An CI, et al. Skelet Muscle. 2013 May 10;3(1):11. doi: 10.1186/2044-5040-3-11. Skelet Muscle. 2013. PMID: 23663701 Free PMC article.
Small interfering RNA (siRNA)-mediated knockdown of one of the Sox6 binding proteins, Trip12, was used to determine its effect on Sox6 activity in C2C12 myotubes using quantitative analysis of fiber type-specific gene expression. RESULTS: We fou …
Small interfering RNA (siRNA)-mediated knockdown of one of the Sox6 binding proteins, Trip12, was used to determine its effect on Sox6 activ …
A novel TCGA-validated programmed cell-death-related signature of ovarian cancer.
Cai X, Lin J, Liu L, Zheng J, Liu Q, Ji L, Sun Y. Cai X, et al. BMC Cancer. 2024 Apr 23;24(1):515. doi: 10.1186/s12885-024-12245-2. BMC Cancer. 2024. PMID: 38654239 Free PMC article.
RESULTS: A ten-PCD-related gene signature including protein phosphatase 1 regulatory subunit 15 A (PPP1R15A), 8-oxoguanine-DNA glycosylase (OGG1), HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (H …
RESULTS: A ten-PCD-related gene signature including protein phosphatase 1 regulatory subunit 15 A (PPP1R15A), 8-oxoguanine-DNA …