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NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T, Yang Y. Li M, et al. Cell Death Dis. 2019 Aug 19;10(9):628. doi: 10.1038/s41419-019-1843-3. Cell Death Dis. 2019. PMID: 31427565 Free PMC article.
Here, we find that NudCL2 is required for accurate centriole duplication by stabilizing the E3 ligase HECT domain and RCC1-like domain-containing protein 2 (HERC2). ...Quantitative proteomic analysis reveals that HERC2 is do …
Here, we find that NudCL2 is required for accurate centriole duplication by stabilizing the E3 ligase HECT domain
Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases.
Scarafia LE, Winter A, Swinney DC. Scarafia LE, et al. Physiol Genomics. 2000 Dec 18;4(2):147-153. doi: 10.1152/physiolgenomics.2000.4.2.147. Physiol Genomics. 2000. PMID: 11120875
We evaluated the expression of 28 gene sequences with homology to the carboxy terminal of HECT E3 ubiquitin ligases in nine human cell lines using RT-PCR, to determine whether gene expression could be associated with cell- …
We evaluated the expression of 28 gene sequences with homology to the carboxy terminal of HECT E3 ubiquitin
Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.
An CI, Ganio E, Hagiwara N. An CI, et al. Skelet Muscle. 2013 May 10;3(1):11. doi: 10.1186/2044-5040-3-11. Skelet Muscle. 2013. PMID: 23663701 Free PMC article.
RESULTS: We found that the E3 ligase Trip12, a HECT domain E3 ubiquitin ligase, recognizes and polyubiquitinates Sox6. Inhibiting Trip12 or the 26S proteasome activity resulted in an increase in Sox6 protein levels in C2C12 …
RESULTS: We found that the E3 ligase Trip12, a HECT domain E3 ubiquitin ligase, recognizes …
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