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Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases.
Scarafia LE, Winter A, Swinney DC. Scarafia LE, et al. Physiol Genomics. 2000 Dec 18;4(2):147-153. doi: 10.1152/physiolgenomics.2000.4.2.147. Physiol Genomics. 2000. PMID: 11120875
We evaluated the expression of 28 gene sequences with homology to the carboxy terminal of HECT E3 ubiquitin ligases in nine human cell lines using RT-PCR, to determine whether gene expression could be associated with cell- …
We evaluated the expression of 28 gene sequences with homology to the carboxy terminal of HECT E3 ubiquitin
NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T, Yang Y. Li M, et al. Cell Death Dis. 2019 Aug 19;10(9):628. doi: 10.1038/s41419-019-1843-3. Cell Death Dis. 2019. PMID: 31427565 Free PMC article.
Here, we find that NudCL2 is required for accurate centriole duplication by stabilizing the E3 ligase HECT domain and RCC1-like domain-containing protein 2 (HERC2). ...Overexpression of NudCL2 significantly suppresses hydroxyurea-induced …
Here, we find that NudCL2 is required for accurate centriole duplication by stabilizing the E3 ligase HECT domain
Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.
An CI, Ganio E, Hagiwara N. An CI, et al. Skelet Muscle. 2013 May 10;3(1):11. doi: 10.1186/2044-5040-3-11. Skelet Muscle. 2013. PMID: 23663701 Free PMC article.
Small interfering RNA (siRNA)-mediated knockdown of one of the Sox6 binding proteins, Trip12, was used to determine its effect on Sox6 activity in C2C12 myotubes using quantitative analysis of fiber type-specific gene expression. RESULTS: We fou …
Small interfering RNA (siRNA)-mediated knockdown of one of the Sox6 binding proteins, Trip12, was used to determine its effect on Sox6 activ …