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1998 1
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Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.
Sengupta TK, Talbot ES, Scherle PA, Ivashkiv LB. Sengupta TK, et al. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11107-12. doi: 10.1073/pnas.95.19.11107. Proc Natl Acad Sci U S A. 1998. PMID: 9736697 Free PMC article.
These inhibitory agents activate mitogen activated protein kinases (MAPKs), and thus the role of MAPKs in the mechanism of inhibition of Stat3 activation was investigated. ...In contrast to IL-6, activation of …
These inhibitory agents activate mitogen activated protein kinases (MAPKs), and thus the role of MAPKs in …
Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.
Ahmed ST, Ivashkiv LB. Ahmed ST, et al. J Immunol. 2000 Nov 1;165(9):5227-37. doi: 10.4049/jimmunol.165.9.5227. J Immunol. 2000. PMID: 11046056 Free article.
Inhibition of Stat activation correlated with inhibition of expression of IL-6-inducible genes. ...Inhibition of IL-6 signaling was mediated by the p38 subfamily of stress-activated protein kinases. ...
Inhibition of Stat activation correlated with inhibition of expression of IL-6-inducible genes. ...Inhibition
Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo?
Sriram K, Benkovic SA, Hebert MA, Miller DB, O'Callaghan JP. Sriram K, et al. J Biol Chem. 2004 May 7;279(19):19936-47. doi: 10.1074/jbc.M309304200. Epub 2004 Mar 2. J Biol Chem. 2004. PMID: 14996842 Free article.
The p44/42 mitogen-activated protein kinase (MAPK; ERK1/2) also was activated by MPTP, but was not associated with activation of STAT3, because serine (Ser-727) was not phosphorylated. The mRNA for ligands of the gp130-JAK/STAT3
The p44/42 mitogen-activated protein kinase (MAPK; ERK1/2) also was activated by MPTP, but was not associated wi …
Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway.
Miranda MB, Xu H, Torchia JA, Johnson DE. Miranda MB, et al. Leuk Res. 2005 Nov;29(11):1293-306. doi: 10.1016/j.leukres.2005.03.016. Leuk Res. 2005. PMID: 16164983
In this study, we examined the importance of the MEK/ERK signal transduction pathway in granulocyte-colony stimulating factor (G-CSF)-induced granulocytic differentiation of murine 32 Dc l3 cells, and in interleukin-6 (IL-6)-induced monoc …
In this study, we examined the importance of the MEK/ERK signal transduction pathway in granulocyte-colony stimulating fact
Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation.
Booz GW, Day JN, Baker KM. Booz GW, et al. Basic Res Cardiol. 2003 Feb;98(1):33-8. doi: 10.1007/s00395-003-0387-x. Basic Res Cardiol. 2003. PMID: 12494267
PD98059 was found to inhibit angiotensin II-induced Erk activation and STAT3 Ser727 phosphorylation. ...These results are consistent with Erk-mediated STAT3 Ser727 phosphorylation leading to STAT3 Tyr705 dephosphorylation, and accounting …
PD98059 was found to inhibit angiotensin II-induced Erk activation and STAT3 Ser727 phosphorylation. ...These results a …