NOD2 stimulation by Staphylococcus aureus-derived peptidoglycan is boosted by Toll-like receptor 2 costimulation with lipoproteins in dendritic cells.
Infect Immun. 2014.
PMID: 25156723
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Receptor 2 stimulation with lipoproteins in dendritic cells
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NOD2 stimulation by Staphylococcus aureus-derived peptidoglycan is boosted by Toll-like receptor 2 costimulation with lipoproteins in dendritic cells.
Infect Immun. 2014 Nov;82(11):4681-8. doi: 10.1128/IAI.02043-14. Epub 2014 Aug 25.
Infect Immun. 2014.
PMID: 25156723
Free PMC article.
Mutations in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) play an important role in the pathogenesis of Crohn's disease. ...Murine bone marrow-derived dendritic cells (BMDCs), J774 cells, and Mono Mac 6 (MM6) cell …
Mutations in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) play an important role in the pathogenesis of …
Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions.
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2495-503. doi: 10.1161/ATVBAHA.110.215459. Epub 2010 Oct 7.
Arterioscler Thromb Vasc Biol. 2010.
PMID: 20930170
Oral calcitriol administration decreased atherosclerotic lesions, macrophage accumulation, and CD4(+) T-cell infiltration at the aortic sinus, when compared with the corresponding observations in control mice. We observed a significant increase in Foxp3(+) regulatory T cells …
Oral calcitriol administration decreased atherosclerotic lesions, macrophage accumulation, and CD4(+) T-cell infiltration at the aortic sinu …
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.
Circulation. 2012 Sep 4;126(10):1256-66. doi: 10.1161/CIRCULATIONAHA.112.099044. Epub 2012 Jul 31.
Circulation. 2012.
PMID: 22851544
Recently, an interleukin (IL)-2/anti-IL-2 neutralizing monoclonal antibody (IL-2/anti-IL-2 mAb) complex has been shown to expand these Tregs. ...Tregs were increased in lesions and lesion size reduced. CD4+ T-cells, macrophages, mature …
Recently, an interleukin (IL)-2/anti-IL-2 neutralizing monoclonal antibody (IL-2/anti-IL-2 mAb) complex h …
Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.
Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1758-65. doi: 10.1161/ATVBAHA.110.206045. Epub 2010 Jun 10.
Arterioscler Thromb Vasc Biol. 2010.
PMID: 20539017
Free PMC article.
This decrease in expansion and cytokine production was accompanied by a 2-fold increase in percentage of iNKT cells expressing the inhibitory marker programmed death-1 in apoE(-/-) mice compared with controls. ...Changes in iNKT cell functions were cell autonomous, …
This decrease in expansion and cytokine production was accompanied by a 2-fold increase in percentage of iNKT cells expressing …
Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling.
Cell Microbiol. 2012 Jan;14(1):40-57. doi: 10.1111/j.1462-5822.2011.01695.x. Epub 2011 Nov 3.
Cell Microbiol. 2012.
PMID: 21899704
Dendritic cells recognize pathogens through pattern recognition receptors such as Toll-like receptors and phagocytose and digest them by phagocytic receptors for antigen presentation. This study was designed to clarify the cross-talk between rec …
Dendritic cells recognize pathogens through pattern recognition receptors such as Toll-like receptors and phagoc …
[Effect of PD-1 deficiency on atherogenic immune responses].
Zhonghua Yi Xue Za Zhi. 2014 Aug 13;94(30):2377-81.
Zhonghua Yi Xue Za Zhi. 2014.
PMID: 25399984
Chinese.
Same changes were detected in both CD3+ CD62L(-) and CD3+ CD25+ cells. PD-1 deficiency in both CD4+ and CD8+ T cells resulted in enhanced proliferation by either macrophages or dendritic cells as antigen presenting cells (APCs). The supernatant …
Same changes were detected in both CD3+ CD62L(-) and CD3+ CD25+ cells. PD-1 deficiency in both CD4+ and CD8+ T cells resulted …
Porphyromonas gingivalis HSP60 peptides have distinct roles in the development of atherosclerosis.
Mol Immunol. 2015 Feb;63(2):489-96. doi: 10.1016/j.molimm.2014.10.004.
Mol Immunol. 2015.
PMID: 25457882
In contrast, the expression level of IFN-gamma and T-bet mRNA, signaling molecules for Th1 cells, was higher in peptide 19-immunized group than in PBS-immunized group.In non-immunized wild mice, BMDC-derived CD11c+ dendritic cells have shown to stimulate Treg …
In contrast, the expression level of IFN-gamma and T-bet mRNA, signaling molecules for Th1 cells, was higher in peptide 19-immunized …
Immunotherapy of tumors with α2-macroglobulin-antigen complexes pre-formed in vivo.
PLoS One. 2012;7(11):e50365. doi: 10.1371/journal.pone.0050365. Epub 2012 Nov 30.
PLoS One. 2012.
PMID: 23226267
Free PMC article.
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and alpha(2)M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or alpha(2)M are cross-presented on MH …
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and alpha(2)M ligands to elicit T cell imm …
Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide.
Front Immunol. 2018 Mar 14;9:496. doi: 10.3389/fimmu.2018.00496. eCollection 2018.
Front Immunol. 2018.
PMID: 29593736
Free PMC article.
Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) 2/TLR6. ...We have chemically synthesized a short form of MALP2 named MALP2s (S-[2,3-bis(palmitoyloxy)propyl]-CGNNDE). MA …
Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) …
Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens.
Sci Transl Med. 2013 May 15;5(185):185ra64. doi: 10.1126/scitranslmed.3005544.
Sci Transl Med. 2013.
PMID: 23677593
Free article.
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsiveness and susceptibility to infections, and may affect adaptive immune responses. ...In vivo, peptide treatment increased phagocyte recruitment …
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsivenes …