Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens.
Raby AC, Holst B, Le Bouder E, Diaz C, Ferran E, Conraux L, Guillemot JC, Coles B, Kift-Morgan A, Colmont CS, Szakmany T, Ferrara P, Hall JE, Topley N, Labéta MO.
Raby AC, et al.
Sci Transl Med. 2013 May 15;5(185):185ra64. doi: 10.1126/scitranslmed.3005544.
Sci Transl Med. 2013.
PMID: 23677593
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsiveness and susceptibility to infections, and may affect adaptive immune responses. ...In vivo, peptide treatment increased phagocyte recruitment …
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsivenes …