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NOD2 stimulation by Staphylococcus aureus-derived peptidoglycan is boosted by Toll-like receptor 2 costimulation with lipoproteins in dendritic cells.
Schäffler H, Demircioglu DD, Kühner D, Menz S, Bender A, Autenrieth IB, Bodammer P, Lamprecht G, Götz F, Frick JS. Schäffler H, et al. Infect Immun. 2014 Nov;82(11):4681-8. doi: 10.1128/IAI.02043-14. Epub 2014 Aug 25. Infect Immun. 2014. PMID: 25156723 Free PMC article.
Mutations in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) play an important role in the pathogenesis of Crohn's disease. ...Murine bone marrow-derived dendritic cells (BMDCs), J774 cells, and Mono Mac 6 (MM6) cell
Mutations in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) play an important role in the pathogenesis of …
Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions.
Takeda M, Yamashita T, Sasaki N, Nakajima K, Kita T, Shinohara M, Ishida T, Hirata K. Takeda M, et al. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2495-503. doi: 10.1161/ATVBAHA.110.215459. Epub 2010 Oct 7. Arterioscler Thromb Vasc Biol. 2010. PMID: 20930170
Oral calcitriol administration decreased atherosclerotic lesions, macrophage accumulation, and CD4(+) T-cell infiltration at the aortic sinus, when compared with the corresponding observations in control mice. We observed a significant increase in Foxp3(+) regulatory T cells
Oral calcitriol administration decreased atherosclerotic lesions, macrophage accumulation, and CD4(+) T-cell infiltration at the aortic sinu …
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.
Dinh TN, Kyaw TS, Kanellakis P, To K, Tipping P, Toh BH, Bobik A, Agrotis A. Dinh TN, et al. Circulation. 2012 Sep 4;126(10):1256-66. doi: 10.1161/CIRCULATIONAHA.112.099044. Epub 2012 Jul 31. Circulation. 2012. PMID: 22851544
Recently, an interleukin (IL)-2/anti-IL-2 neutralizing monoclonal antibody (IL-2/anti-IL-2 mAb) complex has been shown to expand these Tregs. ...Tregs were increased in lesions and lesion size reduced. CD4+ T-cells, macrophages, mature …
Recently, an interleukin (IL)-2/anti-IL-2 neutralizing monoclonal antibody (IL-2/anti-IL-2 mAb) complex h …
Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.
Braun NA, Mendez-Fernandez YV, Covarrubias R, Porcelli SA, Savage PB, Yagita H, Van Kaer L, Major AS. Braun NA, et al. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1758-65. doi: 10.1161/ATVBAHA.110.206045. Epub 2010 Jun 10. Arterioscler Thromb Vasc Biol. 2010. PMID: 20539017 Free PMC article.
This decrease in expansion and cytokine production was accompanied by a 2-fold increase in percentage of iNKT cells expressing the inhibitory marker programmed death-1 in apoE(-/-) mice compared with controls. ...Changes in iNKT cell functions were cell autonomous, …
This decrease in expansion and cytokine production was accompanied by a 2-fold increase in percentage of iNKT cells expressing …
Porphyromonas gingivalis HSP60 peptides have distinct roles in the development of atherosclerosis.
Jeong E, Kim K, Kim JH, Cha GS, Kim SJ, Kang HS, Choi J. Jeong E, et al. Mol Immunol. 2015 Feb;63(2):489-96. doi: 10.1016/j.molimm.2014.10.004. Mol Immunol. 2015. PMID: 25457882
In contrast, the expression level of IFN-gamma and T-bet mRNA, signaling molecules for Th1 cells, was higher in peptide 19-immunized group than in PBS-immunized group.In non-immunized wild mice, BMDC-derived CD11c+ dendritic cells have shown to stimulate Treg …
In contrast, the expression level of IFN-gamma and T-bet mRNA, signaling molecules for Th1 cells, was higher in peptide 19-immunized …
Immunotherapy of tumors with α2-macroglobulin-antigen complexes pre-formed in vivo.
Pawaria S, Kropp LE, Binder RJ. Pawaria S, et al. PLoS One. 2012;7(11):e50365. doi: 10.1371/journal.pone.0050365. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226267 Free PMC article.
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and alpha(2)M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or alpha(2)M are cross-presented on MH …
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and alpha(2)M ligands to elicit T cell imm …
Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling.
Ohtani M, Iyori M, Saeki A, Tanizume N, Into T, Hasebe A, Totsuka Y, Shibata K. Ohtani M, et al. Cell Microbiol. 2012 Jan;14(1):40-57. doi: 10.1111/j.1462-5822.2011.01695.x. Epub 2011 Nov 3. Cell Microbiol. 2012. PMID: 21899704
Dendritic cells recognize pathogens through pattern recognition receptors such as Toll-like receptors and phagocytose and digest them by phagocytic receptors for antigen presentation. This study was designed to clarify the cross-talk between rec
Dendritic cells recognize pathogens through pattern recognition receptors such as Toll-like receptors and phagoc
Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens.
Raby AC, Holst B, Le Bouder E, Diaz C, Ferran E, Conraux L, Guillemot JC, Coles B, Kift-Morgan A, Colmont CS, Szakmany T, Ferrara P, Hall JE, Topley N, Labéta MO. Raby AC, et al. Sci Transl Med. 2013 May 15;5(185):185ra64. doi: 10.1126/scitranslmed.3005544. Sci Transl Med. 2013. PMID: 23677593
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsiveness and susceptibility to infections, and may affect adaptive immune responses. ...In vivo, peptide treatment increased phagocyte recruitment …
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsivenes …
Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide.
Takeda Y, Azuma M, Funami K, Shime H, Matsumoto M, Seya T. Takeda Y, et al. Front Immunol. 2018 Mar 14;9:496. doi: 10.3389/fimmu.2018.00496. eCollection 2018. Front Immunol. 2018. PMID: 29593736 Free PMC article.
Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) 2/TLR6. ...We have chemically synthesized a short form of MALP2 named MALP2s (S-[2,3-bis(palmitoyloxy)propyl]-CGNNDE). MA …
Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) …
Generation of HSP60-specific regulatory T cell and effect on atherosclerosis.
Yang K, Li D, Luo M, Hu Y. Yang K, et al. Cell Immunol. 2006 Oct;243(2):90-5. doi: 10.1016/j.cellimm.2007.01.002. Epub 2007 Feb 26. Cell Immunol. 2006. PMID: 17324390
Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RPM)-treated immature dendritic cells in vitro and explore their effect on plaques in apolipoprotein E-deficient mice. Rapamycin-treated bone marr …
Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RPM)-treated immatur …
17 results