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Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells.
Jayawickreme SP, Gray T, Nettesheim P, Eling T. Jayawickreme SP, et al. Am J Physiol. 1999 Apr;276(4):L596-603. doi: 10.1152/ajplung.1999.276.4.L596. Am J Physiol. 1999. PMID: 10198357
Our laboratory has recently shown that mucus differentiation of cultured normal human tracheobronchial epithelial (NHTBE) cells is accompanied by the increased expression of 15-lipoxygenase (15-LO). We used differentiated NHTBE cells
Our laboratory has recently shown that mucus differentiation of cultured normal human tracheobronchial epithelial (NHTBE) cells
Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4.
Brinckmann R, Topp MS, Zalán I, Heydeck D, Ludwig P, Kühn H, Berdel WE, Habenicht JR. Brinckmann R, et al. Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):305-12. doi: 10.1042/bj3180305. Biochem J. 1996. PMID: 8761486 Free PMC article.
Other cell lines, including several epithelial cells and various monocytic cell lines expressing comparable numbers of interleukin-4 receptors, did not express 15-lipoxygenase when stimulated with interleukin-4
Other cell lines, including several epithelial cells and various monocytic cell lines expressing comparable numbers of …
Regulation of 15-lipoxygenase isozymes and mucin secretion by cytokines in cultured normal human bronchial epithelial cells.
Brown CD, Kilty I, Yeadon M, Jenkinson S. Brown CD, et al. Inflamm Res. 2001 Jun;50(6):321-6. doi: 10.1007/PL00000251. Inflamm Res. 2001. PMID: 11475334
OBJECTIVE AND DESIGN: To study the effects of IL-4, IL-13, IL-1beta, IL-8 and TNFalpha on 15-lipoxygenase(15-LO) isozyme expression and mucin secretion in normal human bronchial epithelial cells. ...CONCLUSIONS: These data demonstr …
OBJECTIVE AND DESIGN: To study the effects of IL-4, IL-13, IL-1beta, IL-8 and TNFalpha on 15-lipoxygenase(15-LO) …
Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells.
Kelavkar UP, Wang S, Badr KF. Kelavkar UP, et al. Genes Immun. 2000;1(4):237-50. doi: 10.1038/sj.gene.6363665. Genes Immun. 2000. PMID: 11196700
As reported previously in human monocytes, a human lung epithelial cell line, A549, showed de novo induction of 15-Lipoxygenase-1 (15-LO-1) in response to interleukins-13 (IL-13) and -4 (IL-4). ...In summary, in A549 cells, …
As reported previously in human monocytes, a human lung epithelial cell line, A549, showed de novo induction of 15-L
Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity.
Sigal E, Sloane DL, Conrad DJ. Sigal E, et al. J Lipid Mediat. 1993 Mar-Apr;6(1-3):75-88. J Lipid Mediat. 1993. PMID: 8358018
In human lung, 15-lipoxygenase is preferentially expressed in airway epithelial cells and eosinophils. ...These data suggest that expression of 15-lipoxygenase is regulated by interleukin-4, and t …
In human lung, 15-lipoxygenase is preferentially expressed in airway epithelial cells and eosinoph …
Eicosanoid biosynthesis during mucociliary and mucous metaplastic differentiation of bronchial epithelial cells.
Jakiela B, Gielicz A, Plutecka H, Hubalewska M, Mastalerz L, Bochenek G, Soja J, Januszek R, Musial J, Sanak M. Jakiela B, et al. Prostaglandins Other Lipid Mediat. 2013 Oct;106:116-23. doi: 10.1016/j.prostaglandins.2013.05.001. Epub 2013 Jun 3. Prostaglandins Other Lipid Mediat. 2013. PMID: 23742951
Treatment with IL-13 and IL-4 induced mucous metaplasia and resulted in downregulation of PG pathway, and potent induction of 15-lipoxygenase (marked release of 15-HETE). ...In conclusions, Th2-type cytokines induce changes in eicosanoid metabolism of …
Treatment with IL-13 and IL-4 induced mucous metaplasia and resulted in downregulation of PG pathway, and potent induction of 15
Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene.
Shankaranarayanan P, Chaitidis P, Kühn H, Nigam S. Shankaranarayanan P, et al. J Biol Chem. 2001 Nov 16;276(46):42753-60. doi: 10.1074/jbc.M102626200. Epub 2001 Aug 16. J Biol Chem. 2001. PMID: 11509556 Free article.
Interleukin-4 (IL-4) induces expression of reticulocyte-type 15-lipoxygenase-1 (15-LOX-1) in various mammalian cells via the Janus kinase/signal transducer and activator of transcription 6 (STAT6) signaling system. We studie
Interleukin-4 (IL-4) induces expression of reticulocyte-type 15-lipoxygenase-1 (15-LOX-1) i
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