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Regulation of HLA class II expression prevents allogeneic T-cell responses.
Jaimes Y, Seltsam A, Eiz-Vesper B, Blasczyk R, Figueiredo C. Jaimes Y, et al. Tissue Antigens. 2011 Jan;77(1):36-44. doi: 10.1111/j.1399-0039.2010.01576.x. Tissue Antigens. 2011. PMID: 21155720
We investigated the effect of silencing either HLA-DR or HLA-DM expression in the allogeneic T-cell responses. ...Direct targeting of HLA-DR expression prevented more efficiently an allogeneic T- …
We investigated the effect of silencing either HLA-DR or HLA-DM expression in the allogeneic T-cell
A future with less HLA: potential clinical applications of HLA-universal cells.
Figueiredo C, Blasczyk R. Figueiredo C, et al. Tissue Antigens. 2015 Jun;85(6):443-9. doi: 10.1111/tan.12564. Epub 2015 Apr 10. Tissue Antigens. 2015. PMID: 25864470 Review.
We have developed a strategy to decrease the immunogenicity of cell and tissues to improve their survival after allogeneic transplantation in the absence of immunosuppression. Using RNA interference technology, the expression of HLA class I and II
We have developed a strategy to decrease the immunogenicity of cell and tissues to improve their survival after allogeneic transplant …
Expression of xenogeneic MHC class II molecules in HLA-DR(+) and -DR(-) cells: influence of retrovirus vector design and cellular context.
Denaro M, Kolber-Simonds D, Schad V, Muthukumar S, Germana S, White-Scharf ME, Banerjee PT, LeGuern C, Andersson G. Denaro M, et al. Xenotransplantation. 2002 Mar;9(2):115-24. doi: 10.1034/j.1399-3089.2002.1o038.x. Xenotransplantation. 2002. PMID: 11897004
We recently established that molecular chimeras of major histocompatibility complex (MHC) class II molecules, created via retroviral transfer of allogeneic class II cDNAs into bone marrow cells (BMCs), alleviated complications associated with mi …
We recently established that molecular chimeras of major histocompatibility complex (MHC) class II molecules, created via retr …
Generation of CD4(+)CD45RA(+) effector T cells by stimulation in the presence of cyclic adenosine 5'-monophosphate-elevating agents.
Suárez A, Mozo L, Gutiérrez C. Suárez A, et al. J Immunol. 2002 Aug 1;169(3):1159-67. doi: 10.4049/jimmunol.169.3.1159. J Immunol. 2002. PMID: 12133935
Inhibition of CD45 splicing by dbcAMP was not reverted by addition of exogenous IL-2. cAMP-primed CD45RA cells had a phenotype characteristic of memory/effector T lymphocytes, as they showed an up-regulated expression of CD2, CD44, and CD11a molecules, …
Inhibition of CD45 splicing by dbcAMP was not reverted by addition of exogenous IL-2. cAMP-primed CD45RA cells had a phenotype characteristi …
Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells.
Péguet-Navarro J, Moulon C, Caux C, Dalbiez-Gauthier C, Banchereau J, Schmitt D. Péguet-Navarro J, et al. Eur J Immunol. 1994 Apr;24(4):884-91. doi: 10.1002/eji.1830240416. Eur J Immunol. 1994. PMID: 8149959
In this study, we analyzed the effect of interleukin-10 (IL-10) on the primary allogeneic T cell response induced by human Langerhans cells (LC), the dendritic cells from epidermis. ...IL-10 inhibited T cell alloreaction induced by 2-day- …
In this study, we analyzed the effect of interleukin-10 (IL-10) on the primary allogeneic T cell response induce …
Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment.
Jackman RP, Heitman JW, Marschner S, Goodrich RP, Norris PJ. Jackman RP, et al. Transfusion. 2009 Dec;49(12):2686-99. doi: 10.1111/j.1537-2995.2009.02333.x. Epub 2009 Aug 4. Transfusion. 2009. PMID: 19682337 Free PMC article.
RESULTS: Compared with untreated controls, ultraviolet (UV)-irradiated antigen-presenting cells showed slightly reduced surface expression of HLA Class II and costimulatory molecules and had more significant reductions in surface expression of a …
RESULTS: Compared with untreated controls, ultraviolet (UV)-irradiated antigen-presenting cells showed slightly reduced surface expressio
Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties.
Buelens C, Bartholomé EJ, Amraoui Z, Boutriaux M, Salmon I, Thielemans K, Willems F, Goldman M. Buelens C, et al. Blood. 2002 Feb 1;99(3):993-8. doi: 10.1182/blood.v99.3.993. Blood. 2002. PMID: 11807004 Free article.
It was observed that interferon beta (IFN-beta) prevents the down-regulation of the interleukin-3 receptor alpha chain (IL-3Ralpha), which spontaneously occurs during culture of human monocytes. ...Monocytes cultured in the presence of IFN-beta and IL-3 acquire a de …
It was observed that interferon beta (IFN-beta) prevents the down-regulation of the interleukin-3 receptor alpha chain (IL-3Ra …
Cross-linking of CD32 induces maturation of human monocyte-derived dendritic cells via NF-kappa B signaling pathway.
Bánki Z, Kacani L, Müllauer B, Wilflingseder D, Obermoser G, Niederegger H, Schennach H, Sprinzl GM, Sepp N, Erdei A, Dierich MP, Stoiber H. Bánki Z, et al. J Immunol. 2003 Apr 15;170(8):3963-70. doi: 10.4049/jimmunol.170.8.3963. J Immunol. 2003. PMID: 12682223
In this study, we show that cross-linking of FcgammaR-type II (CD32) with immobilized IgG (imIgG) can induce maturation of human monocyte-derived DC via the NF-kappaB signaling pathway. ...Furthermore, DC cultivated in the presence of imIgG induced allogeneic T
In this study, we show that cross-linking of FcgammaR-type II (CD32) with immobilized IgG (imIgG) can induce maturation of human mono …