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Regulation of expression of the human monocyte chemotactic protein-1 receptor (hCCR2) by cytokines.
Tangirala RK, Murao K, Quehenberger O. Tangirala RK, et al. J Biol Chem. 1997 Mar 21;272(12):8050-6. doi: 10.1074/jbc.272.12.8050. J Biol Chem. 1997. PMID: 9065478 Free article.
To better understand the role of the human MCP-1 receptor (hCCR2) in monocyte recruitment, we have examined the effects of cytokines on expression of the receptor gene by ligand binding and Northern blot analysis. ... …
To better understand the role of the human MCP-1 receptor (hCCR2) in monocyte recruitment, we have examin …
Cloning and functional characterization of the 5'-flanking region of the human monocyte chemoattractant protein-1 receptor (CCR2) gene. Essential role of 5'-untranslated region in tissue-specific expression.
Yamamoto K, Takeshima H, Hamada K, Nakao M, Kino T, Nishi T, Kochi M, Kuratsu J, Yoshimura T, Ushio Y. Yamamoto K, et al. J Biol Chem. 1999 Feb 19;274(8):4646-54. doi: 10.1074/jbc.274.8.4646. J Biol Chem. 1999. PMID: 9988701 Free article.
The human monocyte chemoattractant protein-1 receptor designated hCCR2 is an essential co-receptor in cell entry by the human immunodeficiency virus as well as a receptor for monocyte chemoattractant protein
The human monocyte chemoattractant protein-1 receptor designated hCCR2 is an essential co-recep
Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.
Buntinx M, Hermans B, Goossens J, Moechars D, Gilissen RA, Doyon J, Boeckx S, Coesemans E, Van Lommen G, Van Wauwe JP. Buntinx M, et al. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9. doi: 10.1124/jpet.108.140723. Epub 2008 Jul 3. J Pharmacol Exp Ther. 2008. PMID: 18599682
The interaction between CC chemokine receptor 2 (CCR2) with monocyte chemoattractant proteins, such as MCP-1, regulates the activation and recruitment of inflammatory leukocytes. ...JNJ-27141491 strongly suppressed hCCR2-mediated in vitro …
The interaction between CC chemokine receptor 2 (CCR2) with monocyte chemoattractant proteins, such as MCP-1, …
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
Shin N, Baribaud F, Wang K, Yang G, Wynn R, Covington MB, Feldman P, Gallagher KB, Leffet LM, Lo YY, Wang A, Xue CB, Newton RC, Scherle PA. Shin N, et al. Biochem Biophys Res Commun. 2009 Sep 18;387(2):251-5. doi: 10.1016/j.bbrc.2009.06.135. Epub 2009 Jul 1. Biochem Biophys Res Commun. 2009. PMID: 19576173
The chemokine receptor 2 (CCR2) directs migration of monocytes and has been proposed to be a drug target for chronic inflammatory diseases. ...The binding of the compound to the receptor is rapid and reversible. INCB3344 potently inhibits hCCR2 binding …
The chemokine receptor 2 (CCR2) directs migration of monocytes and has been proposed to be a drug target for chronic inflammat …
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