Regulation of interleukin-6 receptor expression by interleukin-6 in human monocytes--a re-examination.
FEBS Lett. 1994.
PMID: 8200444
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Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes.
FEBS Lett. 1989.
PMID: 2498129
Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes.
J Exp Med. 1989.
PMID: 2809509
Free PMC article.
Search results
Page 1
IL-6 translation is a therapeutic target of human cytokine release syndrome.
J Exp Med. 2023 Nov 6;220(11):e20230577. doi: 10.1084/jem.20230577. Epub 2023 Aug 16.
J Exp Med. 2023.
PMID: 37584653
Free PMC article.
Here, an accidental clinical observation raised the possibility that metoprolol, an FDA-approved beta1 adrenergic receptor blocker widely used for cardiovascular conditions, may alleviate CAR T-induced CRS. Metoprolol effectively blocked IL-6 production in human monocyt …
Here, an accidental clinical observation raised the possibility that metoprolol, an FDA-approved beta1 adrenergic receptor blocker widely us …
Myeloid-Cell-Specific IL-6 Signaling Promotes MicroRNA-223-Enriched Exosome Production to Attenuate NAFLD-Associated Fibrosis.
Hepatology. 2021 Jul;74(1):116-132. doi: 10.1002/hep.31658. Epub 2021 Apr 27.
Hepatology. 2021.
PMID: 33236445
Free PMC article.
Mechanistically, the increased LF in HFD-fed, myeloid-specific Il6ra KO mice was attributable to the reduction of antifibrotic miR-223 and subsequent up-regulation of the miR-223 target gene, transcriptional activator with PDZ-binding motif (TAZ), a well-known facto …
Mechanistically, the increased LF in HFD-fed, myeloid-specific Il6ra KO mice was attributable to the reduction of antifibrotic miR-223 and s …
MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.
Mol Cancer. 2019 Mar 18;18(1):42. doi: 10.1186/s12943-019-0988-0.
Mol Cancer. 2019.
PMID: 30885232
Free PMC article.
RESULTS: We found that the oncogene Multiple Copies in T-cell Malignancy 1 (MCT-1/MCTS1) expression is a new poor-prognosis marker in patients with aggressive breast cancers. ...MCT-1 stimulated interleukin-6 (IL-6) secretion that promoted monocytic TH …
RESULTS: We found that the oncogene Multiple Copies in T-cell Malignancy 1 (MCT-1/MCTS1) expression is a new poor-prognosis marker in …
Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes.
FEBS Lett. 1989 May 22;249(1):27-30. doi: 10.1016/0014-5793(89)80008-0.
FEBS Lett. 1989.
PMID: 2498129
Free article.
Human blood monocytes normally express the interleukin-6 receptor. ...Glucocorticoids aso cause a drop in monocytic interleukin-6 receptor mRNA levels. We also found interleukin-6 receptor …
Human blood monocytes normally express the interleukin-6 receptor. ...Glucocorticoids aso cause a …
ApoE production in human monocytes and its regulation by inflammatory cytokines.
PLoS One. 2013 Nov 14;8(11):e79908. doi: 10.1371/journal.pone.0079908. eCollection 2013.
PLoS One. 2013.
PMID: 24244577
Free PMC article.
In PBMC, apoE secretion was restricted to monocytes with classical (CD14(++)CD16(-)) and intermediate (CD14(+)CD16(+)) monocytes being the main producers. ...Other cytokines tested, IL-2, IL-4, IL-12, IL-13, IL-17A and IL-23, had no inhibitory effect on apoE product …
In PBMC, apoE secretion was restricted to monocytes with classical (CD14(++)CD16(-)) and intermediate (CD14(+)CD16(+)) monocytes …
Regulation of interleukin-6 receptor expression by interleukin-6 in human monocytes--a re-examination.
FEBS Lett. 1994 May 30;345(2-3):131-4. doi: 10.1016/0014-5793(94)00416-1.
FEBS Lett. 1994.
PMID: 8200444
Free article.
We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp130 in primary human blood monocytes. Here, we show that freshly isolated human monocytes express m …
We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transdu …
Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder.
J Affect Disord. 2018 Oct 15;239:152-160. doi: 10.1016/j.jad.2018.06.037. Epub 2018 Jun 25.
J Affect Disord. 2018.
PMID: 30014955
Since elevations in IL-6R have repeatedly been demonstrated in bipolar disorder the association of sleep quality and architecture with levels of mRNA coding for IL-6R in monocytes was to be tested. METHODS: Euthymic patients with bipolar disorder (n = 24) and healthy co …
Since elevations in IL-6R have repeatedly been demonstrated in bipolar disorder the association of sleep quality and architecture with level …
Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes.
J Exp Med. 1989 Nov 1;170(5):1537-49. doi: 10.1084/jem.170.5.1537.
J Exp Med. 1989.
PMID: 2809509
Free PMC article.
Stimulation of monocytes by endotoxin or IL-1 causes a rapid downregulation of IL-6-R mRNA levels and a concomitant enhancement of IL-6 mRNA expression. ...A gradual decrease of IL-6-R mRNA levels was observed along in vitro maturation of monocytes into macro …
Stimulation of monocytes by endotoxin or IL-1 causes a rapid downregulation of IL-6-R mRNA levels and a concomitant enhancement of IL …
C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1).
Mol Med. 2015 Feb 5;20(1):559-68. doi: 10.2119/molmed.2014.00185.
Mol Med. 2015.
PMID: 25247291
Free PMC article.
In SLE, inappropriate activation of monocytes is thought to contribute to the loss of self-tolerance. In this study, we demonstrate that type 1 interferon (IFN) production by CpG-challenged monocytes can be suppressed by C1q through activating leukocyte-associated I …
In SLE, inappropriate activation of monocytes is thought to contribute to the loss of self-tolerance. In this study, we demonstrate t …
Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells.
BMB Rep. 2019 Mar;52(3):214-219. doi: 10.5483/BMBRep.2019.52.3.308.
BMB Rep. 2019.
PMID: 30670152
Free PMC article.
In this study, we report a novel mechanism by which endothelial miR-125a and let-7e-mediated regulation of interleukin-6 (IL-6) signaling can manipulate vasculogenic mimicry (VM) formation of MDA-MB-231 breast cancer cells. ...We additionally found an inverse …
In this study, we report a novel mechanism by which endothelial miR-125a and let-7e-mediated regulation of interleukin-6 …
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