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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1993 2
1994 3
1995 6
1996 5
1997 3
1998 10
1999 7
2000 19
2001 12
2002 17
2003 17
2004 16
2005 21
2006 27
2007 15
2008 20
2009 21
2010 15
2011 26
2012 15
2013 22
2014 21
2015 15
2016 12
2017 14
2018 15
2019 7
2020 9
2021 8
2022 0
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368 results
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Page 1
The ADAM metalloproteinases.
Edwards DR, Handsley MM, Pennington CJ. Edwards DR, et al. Mol Aspects Med. 2008 Oct;29(5):258-89. doi: 10.1016/j.mam.2008.08.001. Epub 2008 Aug 15. Mol Aspects Med. 2008. PMID: 18762209 Free PMC article. Review.
The archetypal activity is shown by ADAM-17 (tumour necrosis factor-alpha convertase, TACE), which is the principal protease involved in the activation of pro-TNF-alpha, but whose sheddase functions cover a broad range of cell surface molecules. …
The archetypal activity is shown by ADAM-17 (tumour necrosis factor-alpha convertase, TACE), which is the princi …
Matrix metalloproteinases: role in arthritis.
Burrage PS, Mix KS, Brinckerhoff CE. Burrage PS, et al. Front Biosci. 2006 Jan 1;11:529-43. doi: 10.2741/1817. Front Biosci. 2006. PMID: 16146751 Free article. Review.
In both diseases, inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) stimulate the production of matrix metalloproteinases (MMPs), enzymes that can degrade all components of the extra …
In both diseases, inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha
Tenascin-C: Form versus function.
Giblin SP, Midwood KS. Giblin SP, et al. Cell Adh Migr. 2015;9(1-2):48-82. doi: 10.4161/19336918.2014.987587. Cell Adh Migr. 2015. PMID: 25482829 Free PMC article. Review.
Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns.
Chatterton DE, Nguyen DN, Bering SB, Sangild PT. Chatterton DE, et al. Int J Biochem Cell Biol. 2013 Aug;45(8):1730-47. doi: 10.1016/j.biocel.2013.04.028. Epub 2013 May 6. Int J Biochem Cell Biol. 2013. PMID: 23660296 Review.
Milk provides a multitude of proteins with anti-inflammatory properties and in this review we gather together some recent significant advances regarding the isolation and proteomic identification of these minor constituents of both human and bovine milk. We introduce the proce
Milk provides a multitude of proteins with anti-inflammatory properties and in this review we gather together some recent significant advanc …
Postprandial lipoproteins and the molecular regulation of vascular homeostasis.
Botham KM, Wheeler-Jones CP. Botham KM, et al. Prog Lipid Res. 2013 Oct;52(4):446-64. doi: 10.1016/j.plipres.2013.06.001. Epub 2013 Jun 15. Prog Lipid Res. 2013. PMID: 23774609 Review.
TRL are implicated in several of these inflammatory processes, including the formation of damaging free radicals, leukocyte activation, endothelial dysfunction and foam cell formation. ...There is extensive evidence indicating that raised postprandial TRL levels are a risk …
TRL are implicated in several of these inflammatory processes, including the formation of damaging free radicals, leukocyte activatio …
A current review of molecular mechanisms regarding osteoarthritis and pain.
Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, Im HJ. Lee AS, et al. Gene. 2013 Sep 25;527(2):440-7. doi: 10.1016/j.gene.2013.05.069. Epub 2013 Jul 2. Gene. 2013. PMID: 23830938 Free PMC article. Review.
OA pain involves a complex integration of sensory, affective, and cognitive processes that integrate a variety of abnormal cellular mechanisms at both peripheral and central (spinal and supraspinal) levels of the nervous system Through studies examined by investigators, th …
OA pain involves a complex integration of sensory, affective, and cognitive processes that integrate a variety of abnormal cellular m …
Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor.
McGeehan GM, Becherer JD, Bast RC Jr, Boyer CM, Champion B, Connolly KM, Conway JG, Furdon P, Karp S, Kidao S, et al. McGeehan GM, et al. Nature. 1994 Aug 18;370(6490):558-61. doi: 10.1038/370558a0. Nature. 1994. PMID: 8052311
Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages. ...The enzyme(s) responsible for processing pro-TNF-alpha has yet to be identified. ...
Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory agent produced primarily by activat
The role of cytokines in osteoarthritis pathophysiology.
Fernandes JC, Martel-Pelletier J, Pelletier JP. Fernandes JC, et al. Biorheology. 2002;39(1-2):237-46. Biorheology. 2002. PMID: 12082286 Review.
By analogy, an inhibitor to the p55 TNF-alpha receptor may also provide a mechanism for abolishing TNF-alpha-induced degradation of cartilage ECM by MMPs. Since TACE is the regulator of TNF-alpha activity, limiting the activity of TACE might als …
By analogy, an inhibitor to the p55 TNF-alpha receptor may also provide a mechanism for abolishing TNF-alpha-induced de …
ADAM Metalloproteinases as Potential Drug Targets.
Camodeca C, Cuffaro D, Nuti E, Rossello A. Camodeca C, et al. Curr Med Chem. 2019;26(15):2661-2689. doi: 10.2174/0929867325666180326164104. Curr Med Chem. 2019. PMID: 29589526 Review.
Sheddases are key to modulation of functional proteins such as the tumor necrosis factor, growth factors, cytokines and their receptors, adhesion proteins, signaling molecules and stress molecules involved in immunity. These activities take part in the reg
Sheddases are key to modulation of functional proteins such as the tumor necrosis factor, growth factors, cytokines and …
Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism.
Christianson CA, Fitzsimmons BL, Shim JH, Agrawal A, Cohen SM, Hua XY, Yaksh TL. Christianson CA, et al. Neuroscience. 2012 Jan 3;200:199-210. doi: 10.1016/j.neuroscience.2011.10.019. Epub 2011 Oct 20. Neuroscience. 2012. PMID: 22056600 Free PMC article.
Here we demonstrate for the first time a mechanism for the regulation of nociceptive processing by spinal MMP-3 during peripheral inflammation. ...This cMMP-3-induced hypersensitivity is concurrent with increased tumor necrosis factor (TNF) in t …
Here we demonstrate for the first time a mechanism for the regulation of nociceptive processing by spinal MMP-3 during periphe …
368 results