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LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis.
Quintero-Espinosa DA, Sanchez-Hernandez S, Velez-Pardo C, Martin F, Jimenez-Del-Rio M. Quintero-Espinosa DA, et al. Int J Mol Sci. 2023 Jun 22;24(13):10474. doi: 10.3390/ijms241310474. Int J Mol Sci. 2023. PMID: 37445652 Free PMC article.
Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in idiopathic and familial Parkinson's disease (PD). ...We found that HEK-293 LRRK2 WT cel …
Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal vulnerability to oxidative stress (OS), mitochondrial impai
Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.
Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G. Haschka D, et al. Mov Disord. 2019 Jan;34(1):114-123. doi: 10.1002/mds.27482. Epub 2018 Oct 11. Mov Disord. 2019. PMID: 30311259
BACKGROUND: Restless legs syndrome is a sensorimotor neurological disorder of the limbs that impairs quality of life and disturbs sleep. However, there has been progress in understanding the disease involving the dopaminergic system as well as iron metabolism …
BACKGROUND: Restless legs syndrome is a sensorimotor neurological disorder of the limbs that impairs quality of life and disturbs sle …
Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A.
Sauer SW, Okun JG, Schwab MA, Crnic LR, Hoffmann GF, Goodman SI, Koeller DM, Kölker S. Sauer SW, et al. J Biol Chem. 2005 Jun 10;280(23):21830-6. doi: 10.1074/jbc.M502845200. Epub 2005 Apr 19. J Biol Chem. 2005. PMID: 15840571 Free article.
It has been suggested before that some of these organic acids may induce excitotoxic cell damage, however, the relevance of bioenergetic impairment is not yet understood. The major aim of our study was to investigate respiratory chain, tricarboxylic acid cycle, and fatty a …
It has been suggested before that some of these organic acids may induce excitotoxic cell damage, however, the relevance of bioenergetic …