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1999 1
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Page 1
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis.
Doddapattar P, Dev R, Ghatge M, Patel RB, Jain M, Dhanesha N, Lentz SR, Chauhan AK. Doddapattar P, et al. Circ Res. 2022 Apr 29;130(9):1289-1305. doi: 10.1161/CIRCRESAHA.121.320704. Epub 2022 Apr 11. Circ Res. 2022. PMID: 35400205 Free PMC article.
BACKGROUND: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic coronary artery disease. However, the role of cell type-specific PKM2 in the setting of atherosclerosis re …
BACKGROUND: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic …
Role of LDL receptor-related protein (LRP) in coronary atherosclerosis.
Schulz S, Birkenmeier G, Schagdarsurengin U, Wenzel K, Müller-Werdan U, Rehfeld D, Süss T, Kabisch A, Werdan K, Gläser C. Schulz S, et al. Int J Cardiol. 2003 Dec;92(2-3):137-44. doi: 10.1016/s0167-5273(03)00090-1. Int J Cardiol. 2003. PMID: 14659844
Among the genetic factors, the cell surface receptor LRP/A2MR (LDL receptor-related protein/alpha2-macroglobulin receptor) was shown to be involved in a variety of biological processes leading to atherosclerotic plaque formation. . …
Among the genetic factors, the cell surface receptor LRP/A2MR (LDL receptor-related protein/alpha2 …
Postprandial lipoproteins and atherosclerosis.
Yu KC, Cooper AD. Yu KC, et al. Front Biosci. 2001 Mar 1;6:D332-54. doi: 10.2741/yu. Front Biosci. 2001. PMID: 11229885 Review.
The liver has a complex chylomicron remnant removal system which is comprised of a combination of different mechanisms that include the low-density-lipoprotein receptor (LDLR) and the LDLR-related-protein (LRP). ...Over the years, …
The liver has a complex chylomicron remnant removal system which is comprised of a combination of different mechanisms that include the l
The mammalian low-density lipoprotein receptor family.
Hussain MM, Strickland DK, Bakillah A. Hussain MM, et al. Annu Rev Nutr. 1999;19:141-72. doi: 10.1146/annurev.nutr.19.1.141. Annu Rev Nutr. 1999. PMID: 10448520 Review.
The LDL-R is the prototype of this family, which also contains very-low-density lipoprotein receptors (VLDL-R), apolipoprotein E receptor 2, LRP, and megalin. ...LDL-R plays an important role in cholesterol homeostasis. Muta …
The LDL-R is the prototype of this family, which also contains very-low-density lipoprotein receptors (VLDL-R), …
LDL-receptor mRNA expression in men is downregulated within an hour of an acute fat load and is influenced by genetic polymorphism.
Pocathikorn A, Taylor RR, James I, Mamotte CD. Pocathikorn A, et al. J Nutr. 2007 Sep;137(9):2062-7. doi: 10.1093/jn/137.9.2062. J Nutr. 2007. PMID: 17709443 Free article.
We investigated the effects of a high-fat meal on circulating mononuclear cell messenger RNA (mRNA) for the LDL receptor (LDLR), LDLR-related protein (LRP), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) over 10 h. Selection of 12 C and 7 …
We investigated the effects of a high-fat meal on circulating mononuclear cell messenger RNA (mRNA) for the LDL receptor (LDLR …
Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels.
Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE. Corsetti JP, et al. PLoS One. 2013 Jul 9;8(7):e68920. doi: 10.1371/journal.pone.0068920. Print 2013. PLoS One. 2013. PMID: 23874812 Free PMC article.
This group of patients was defined as having concurrently high levels of high-density lipoprotein cholesterol (HDL-C) and C-reactive protein (CRP) and was previously demonstrated to be at high-risk for recurrent coronary events. Potential risk associat …
This group of patients was defined as having concurrently high levels of high-density lipoprotein cholesterol (HDL-C) and C-re …
Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation.
Quinn KL, Henriques M, Tabuchi A, Han B, Yang H, Cheng WE, Tole S, Yu H, Luo A, Charbonney E, Tullis E, Lazarus A, Robinson LA, Ni H, Peterson BR, Kuebler WM, Slutsky AS, Zhang H. Quinn KL, et al. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2070-9. doi: 10.1161/ATVBAHA.111.227116. Epub 2011 Aug 4. Arterioscler Thromb Vasc Biol. 2011. PMID: 21817096 Free PMC article.
We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis. ...The administration of superoxide dismutase or anti-CD36 antibody reduced foam cell formation and cholesterol efflux. Mice deficient i …
We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis
The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population.
Benes P, Muzík J, Benedík J, Znojil V, Vácha J. Benes P, et al. Hum Biol. 2002 Feb;74(1):129-36. Hum Biol. 2002. PMID: 11931574
Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery disease (CAD), which is strongly genetically determined. This study was designed to investigate the relationship between the K-IV and …
Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery
Lipid-lowering and antiatherosclerotic effect of NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits.
Suzuki H, Yamazaki H, Aoki T, Kojima J, Tamaki T, Sato F, Kitahara M, Saito Y. Suzuki H, et al. Arzneimittelforschung. 2000 Nov;50(11):995-1003. doi: 10.1055/s-0031-1300323. Arzneimittelforschung. 2000. PMID: 11187394

It lowered plasma total cholesterol (TC, 7-20%) and triglyceride (TG, 16-39%) levels throughout the experimental period due to a significant reduction of very low density lipoprotein cholesterol (VLDL-C, 61-62%, p < 0.05), intermediate density li

It lowered plasma total cholesterol (TC, 7-20%) and triglyceride (TG, 16-39%) levels throughout the experimental period due to a significant …