Role of LDL receptor-related protein (LRP) in coronary atherosclerosis.
Int J Cardiol. 2003.
PMID: 14659844
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Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis.
Circ Res. 2022 Apr 29;130(9):1289-1305. doi: 10.1161/CIRCRESAHA.121.320704. Epub 2022 Apr 11.
Circ Res. 2022.
PMID: 35400205
Free PMC article.
BACKGROUND: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic coronary artery disease. However, the role of cell type-specific PKM2 in the setting of atherosclerosis re …
BACKGROUND: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic …
Role of LDL receptor-related protein (LRP) in coronary atherosclerosis.
Int J Cardiol. 2003 Dec;92(2-3):137-44. doi: 10.1016/s0167-5273(03)00090-1.
Int J Cardiol. 2003.
PMID: 14659844
Among the genetic factors, the cell surface receptor LRP/A2MR (LDL receptor-related protein/alpha2-macroglobulin receptor) was shown to be involved in a variety of biological processes leading to atherosclerotic plaque formation. . …
Among the genetic factors, the cell surface receptor LRP/A2MR (LDL receptor-related protein/alpha2 …
Postprandial lipoproteins and atherosclerosis.
Front Biosci. 2001 Mar 1;6:D332-54. doi: 10.2741/yu.
Front Biosci. 2001.
PMID: 11229885
Review.
The liver has a complex chylomicron remnant removal system which is comprised of a combination of different mechanisms that include the low-density-lipoprotein receptor (LDLR) and the LDLR-related-protein (LRP). Furthermore, it has …
The liver has a complex chylomicron remnant removal system which is comprised of a combination of different mechanisms that include the l …
The mammalian low-density lipoprotein receptor family.
Annu Rev Nutr. 1999;19:141-72. doi: 10.1146/annurev.nutr.19.1.141.
Annu Rev Nutr. 1999.
PMID: 10448520
Review.
The LDL-R is the prototype of this family, which also contains very-low-density lipoprotein receptors (VLDL-R), apolipoprotein E receptor 2, LRP, and megalin. ...LDL-R plays an important role in cholesterol homeostasis. Muta …
The LDL-R is the prototype of this family, which also contains very-low-density lipoprotein receptors (VLDL-R), …
LDL-receptor mRNA expression in men is downregulated within an hour of an acute fat load and is influenced by genetic polymorphism.
J Nutr. 2007 Sep;137(9):2062-7. doi: 10.1093/jn/137.9.2062.
J Nutr. 2007.
PMID: 17709443
Free article.
We investigated the effects of a high-fat meal on circulating mononuclear cell messenger RNA (mRNA) for the LDL receptor (LDLR), LDLR-related protein (LRP), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) over 10 h. Selection of 12 C and 7 …
We investigated the effects of a high-fat meal on circulating mononuclear cell messenger RNA (mRNA) for the LDL receptor (LDLR …
Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation.
Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2070-9. doi: 10.1161/ATVBAHA.111.227116. Epub 2011 Aug 4.
Arterioscler Thromb Vasc Biol. 2011.
PMID: 21817096
Free PMC article.
We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis. ...The administration of superoxide dismutase or anti-CD36 antibody reduced foam cell formation and cholesterol efflux. Mice deficient i …
We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis …
Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels.
PLoS One. 2013 Jul 9;8(7):e68920. doi: 10.1371/journal.pone.0068920. Print 2013.
PLoS One. 2013.
PMID: 23874812
Free PMC article.
This group of patients was defined as having concurrently high levels of high-density lipoprotein cholesterol (HDL-C) and C-reactive protein (CRP) and was previously demonstrated to be at high-risk for recurrent coronary events. Potential risk associat …
This group of patients was defined as having concurrently high levels of high-density lipoprotein cholesterol (HDL-C) and C-re …
The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population.
Hum Biol. 2002 Feb;74(1):129-36.
Hum Biol. 2002.
PMID: 11931574
Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery disease (CAD), which is strongly genetically determined. This study was designed to investigate the relationship between the K-IV and …
Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery …
Lipid-lowering and antiatherosclerotic effect of NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits.
Arzneimittelforschung. 2000 Nov;50(11):995-1003. doi: 10.1055/s-0031-1300323.
Arzneimittelforschung. 2000.
PMID: 11187394
It lowered plasma total cholesterol (TC, 7-20%) and triglyceride (TG, 16-39%) levels throughout the experimental period due to a significant reduction of very low density lipoprotein cholesterol (VLDL-C, 61-62%, p < 0.05), intermediate density li
…
It lowered plasma total cholesterol (TC, 7-20%) and triglyceride (TG, 16-39%) levels throughout the experimental period due to a significant …
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