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Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
Gauss KA, Nelson-Overton LK, Siemsen DW, Gao Y, DeLeo FR, Quinn MT. Gauss KA, et al. J Leukoc Biol. 2007 Sep;82(3):729-41. doi: 10.1189/jlb.1206735. Epub 2007 May 31. J Leukoc Biol. 2007. PMID: 17537988
These data demonstrate that the increase in and/or maintenance of O2*- production in TNF-alpha-treated MonoMac1 cells and monocytes are a result, in part, of transcriptional up-regulation of three essential NADPH oxidase genes via the NF- …
These data demonstrate that the increase in and/or maintenance of O2*- production in TNF-alpha-treated MonoMac1 cells and monocytes a …
Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kappaB/AP-1 signaling pathways in macrophages.
Youn GS, Lee KW, Choi SY, Park J. Youn GS, et al. Free Radic Biol Med. 2016 Aug;97:14-23. doi: 10.1016/j.freeradbiomed.2016.05.014. Epub 2016 May 18. Free Radic Biol Med. 2016. PMID: 27208785
HDAC6 overexpression significantly induced ROS generation via upregulation of NADPH oxidase expression and activity. Inhibition of ROS generation by N-acetyl cysteine, diphenyl iodonium and apocynin suppressed HDAC6-induced pro-inflammatory cytokines. ...Furthermore …
HDAC6 overexpression significantly induced ROS generation via upregulation of NADPH oxidase expression and activity. Inhibitio …
The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by Mycobacterium tuberculosis ESAT-6.
Liu W, Peng Y, Yin Y, Zhou Z, Zhou W, Dai Y. Liu W, et al. Inflammation. 2014 Jun;37(3):880-92. doi: 10.1007/s10753-013-9808-7. Inflammation. 2014. PMID: 24408010
Moreover, TLR2 was engaged in ESAT-6-stimulated macrophage activation via rapidly induced ROS production and regulated activation of JNK/p38 MAPKs and NF-kappaB. More importantly, NADPH oxidase-mediated ROS generation is required during this pro …
Moreover, TLR2 was engaged in ESAT-6-stimulated macrophage activation via rapidly induced ROS production and regulated activation of …
Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
Koumakis E, Millet-Botti J, Benna JE, Leroy C, Boitez V, Codogno P, Friedlander G, Forand A. Koumakis E, et al. Sci Rep. 2019 Feb 12;9(1):1808. doi: 10.1038/s41598-018-37551-1. Sci Rep. 2019. PMID: 30755642 Free PMC article.
Recent data suggest a relationship between PiT1 and NF-kappaB-dependent inflammation: (i) Pit1 mRNA is up-regulated in the context of NF-kappaB pathway activation; (ii) NF-kappaB target gene transcription is decreased in PiT …
Recent data suggest a relationship between PiT1 and NF-kappaB-dependent inflammation: (i) Pit1 mRNA is up-regulated in …
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Lin SJ, Shyue SK, Hung YY, Chen YH, Ku HH, Chen JW, Tam KB, Chen YL. Lin SJ, et al. Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):334-40. doi: 10.1161/01.ATV.0000152114.00114.d8. Epub 2004 Dec 2. Arterioscler Thromb Vasc Biol. 2005. PMID: 15576639
It also attenuated intracellular superoxide anion production and NADPH oxidase activity in TNF-alpha-treated HAECs. CONCLUSIONS: These results provide evidence that SOD expression in endothelial cells attenuates TNF-alpha-induced superoxide anion produ …
It also attenuated intracellular superoxide anion production and NADPH oxidase activity in TNF-alpha-treated HAECs. CON …
Clematichinenoside inhibits VCAM-1 and ICAM-1 expression in TNF-alpha-treated endothelial cells via NADPH oxidase-dependent IkappaB kinase/NF-kappaB pathway.
Yan S, Zhang X, Zheng H, Hu D, Zhang Y, Guan Q, Liu L, Ding Q, Li Y. Yan S, et al. Free Radic Biol Med. 2015 Jan;78:190-201. doi: 10.1016/j.freeradbiomed.2014.11.004. Epub 2014 Nov 13. Free Radic Biol Med. 2015. PMID: 25463279
First, we found that AR reduced TNF-alpha-induced VCAM-1 and ICAM-1 expression and their promoter activity, inhibited translocation of p65 and phosphorylation of IkappaBalpha, suppressed IkappaB kinase-beta (IKK-beta) activity, lowered O2(-) and H2O2 levels, tackled p47(ph …
First, we found that AR reduced TNF-alpha-induced VCAM-1 and ICAM-1 expression and their promoter activity, inhibited translocation o …
Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants.
Carluccio MA, Ancora MA, Massaro M, Carluccio M, Scoditti E, Distante A, Storelli C, De Caterina R. Carluccio MA, et al. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2344-54. doi: 10.1152/ajpheart.00432.2007. Epub 2007 Jun 22. Am J Physiol Heart Circ Physiol. 2007. PMID: 17586618 Free article.
Hcy-induced NF-kappaB activation was confirmed by EMSA, as shown by the nuclear translocation of its p65 (RelA) subunit and the degradation of the inhibitors IkappaB-alpha and IkappaB-beta by Western analysis. ...NF-kappaB inhibitors decreased H …
Hcy-induced NF-kappaB activation was confirmed by EMSA, as shown by the nuclear translocation of its p65 (RelA) subunit and th …
Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes.
Figarola JL, Shanmugam N, Natarajan R, Rahbar S. Figarola JL, et al. Diabetes. 2007 Mar;56(3):647-55. doi: 10.2337/db06-0936. Diabetes. 2007. PMID: 17327432
These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation, as LR-90 suppressed both S100b-and tumor necrosis factor-alpha-induced IkappaB-alpha degradation as well as NF
These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation, as LR-90 …
Ethanol-induced sensitization to endotoxin in Kupffer cells is dependent upon oxidative stress.
Yamashina S, Takei Y, Ikejima K, Enomoto N, Kitamura T, Sato N. Yamashina S, et al. Alcohol Clin Exp Res. 2005 Dec;29(12 Suppl):246S-50S. doi: 10.1097/01.alc.0000191128.54871.40. Alcohol Clin Exp Res. 2005. PMID: 16385231
Moreover, it was shown that Kupffer cell activation by endotoxin via Toll-like receptor (TLR)-4 is involved in alcohol-induced liver injury and ethanol-induced oxidative stress is important in the regulation of transcription factor NFkappaB activation and cyt …
Moreover, it was shown that Kupffer cell activation by endotoxin via Toll-like receptor (TLR)-4 is involved in alcohol-induced liver injury …
Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection.
Kawahara T, Kuwano Y, Teshima-Kondo S, Kawai T, Nikawa T, Kishi K, Rokutan K. Kawahara T, et al. J Med Invest. 2001 Aug;48(3-4):190-7. J Med Invest. 2001. PMID: 11694959
Gastric pit cells express mitogen oxidase1 (Mox1) and essential components for the phagocyte NADPH oxidase (p67-, p47-, p40-, and p22-phoxes). Helicobacter pylori (Hp) lipopolysaccharide (LPS) is a potent up-regulator of the Mox 1 oxidase. ...Ne …
Gastric pit cells express mitogen oxidase1 (Mox1) and essential components for the phagocyte NADPH oxidase (p67-, p47-, …