Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
J Leukoc Biol. 2007.
PMID: 17537988
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Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
J Leukoc Biol. 2007 Sep;82(3):729-41. doi: 10.1189/jlb.1206735. Epub 2007 May 31.
J Leukoc Biol. 2007.
PMID: 17537988
These data demonstrate that the increase in and/or maintenance of O2*- production in TNF-alpha-treated MonoMac1 cells and monocytes are a result, in part, of transcriptional up-regulation of three essential NADPH oxidase genes via the NF- …
These data demonstrate that the increase in and/or maintenance of O2*- production in TNF-alpha-treated MonoMac1 cells and monocytes a …
Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kappaB/AP-1 signaling pathways in macrophages.
Free Radic Biol Med. 2016 Aug;97:14-23. doi: 10.1016/j.freeradbiomed.2016.05.014. Epub 2016 May 18.
Free Radic Biol Med. 2016.
PMID: 27208785
HDAC6 overexpression significantly enhanced expression of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, with concomitant reduction in acetylated alpha-tubulin. HDAC6 overexpression significantly induced ROS generation via upregulation of NADP …
HDAC6 overexpression significantly enhanced expression of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, with con …
The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by Mycobacterium tuberculosis ESAT-6.
Inflammation. 2014 Jun;37(3):880-92. doi: 10.1007/s10753-013-9808-7.
Inflammation. 2014.
PMID: 24408010
Moreover, TLR2 was engaged in ESAT-6-stimulated macrophage activation via rapidly induced ROS production and regulated activation of JNK/p38 MAPKs and NF-kappaB. More importantly, NADPH oxidase-mediated ROS generation is required during this pro …
Moreover, TLR2 was engaged in ESAT-6-stimulated macrophage activation via rapidly induced ROS production and regulated activation of …
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):334-40. doi: 10.1161/01.ATV.0000152114.00114.d8. Epub 2004 Dec 2.
Arterioscler Thromb Vasc Biol. 2005.
PMID: 15576639
It also attenuated intracellular superoxide anion production and NADPH oxidase activity in TNF-alpha-treated HAECs. CONCLUSIONS: These results provide evidence that SOD expression in endothelial cells attenuates TNF-alpha-induced superoxide anion produ …
It also attenuated intracellular superoxide anion production and NADPH oxidase activity in TNF-alpha-treated HAECs. CON …
Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
Sci Rep. 2019 Feb 12;9(1):1808. doi: 10.1038/s41598-018-37551-1.
Sci Rep. 2019.
PMID: 30755642
Free PMC article.
Recent data suggest a relationship between PiT1 and NF-kappaB-dependent inflammation: (i) Pit1 mRNA is up-regulated in the context of NF-kappaB pathway activation; (ii) NF-kappaB target gene transcription is decreased in PiT …
Recent data suggest a relationship between PiT1 and NF-kappaB-dependent inflammation: (i) Pit1 mRNA is up-regulated in …
Clematichinenoside inhibits VCAM-1 and ICAM-1 expression in TNF-alpha-treated endothelial cells via NADPH oxidase-dependent IkappaB kinase/NF-kappaB pathway.
Free Radic Biol Med. 2015 Jan;78:190-201. doi: 10.1016/j.freeradbiomed.2014.11.004. Epub 2014 Nov 13.
Free Radic Biol Med. 2015.
PMID: 25463279
First, we found that AR reduced TNF-alpha-induced VCAM-1 and ICAM-1 expression and their promoter activity, inhibited translocation of p65 and phosphorylation of IkappaBalpha, suppressed IkappaB kinase-beta (IKK-beta) activity, lowered O2(-) and H2O2 levels, tackled p47(ph …
First, we found that AR reduced TNF-alpha-induced VCAM-1 and ICAM-1 expression and their promoter activity, inhibited translocation o …
Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants.
Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2344-54. doi: 10.1152/ajpheart.00432.2007. Epub 2007 Jun 22.
Am J Physiol Heart Circ Physiol. 2007.
PMID: 17586618
Free article.
Hcy-induced NF-kappaB activation was confirmed by EMSA, as shown by the nuclear translocation of its p65 (RelA) subunit and the degradation of the inhibitors IkappaB-alpha and IkappaB-beta by Western analysis. Hcy also increased intracellular reactive oxygen …
Hcy-induced NF-kappaB activation was confirmed by EMSA, as shown by the nuclear translocation of its p65 (RelA) subunit and th …
Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes.
Diabetes. 2007 Mar;56(3):647-55. doi: 10.2337/db06-0936.
Diabetes. 2007.
PMID: 17327432
These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation, as LR-90 suppressed both S100b-and tumor necrosis factor-alpha-induced IkappaB-alpha degradation as well as NF …
These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation, as LR-90 …
Ethanol-induced sensitization to endotoxin in Kupffer cells is dependent upon oxidative stress.
Alcohol Clin Exp Res. 2005 Dec;29(12 Suppl):246S-50S. doi: 10.1097/01.alc.0000191128.54871.40.
Alcohol Clin Exp Res. 2005.
PMID: 16385231
Moreover, it was shown that Kupffer cell activation by endotoxin via Toll-like receptor (TLR)-4 is involved in alcohol-induced liver injury and ethanol-induced oxidative stress is important in the regulation of transcription factor NFkappaB activation and cyt …
Moreover, it was shown that Kupffer cell activation by endotoxin via Toll-like receptor (TLR)-4 is involved in alcohol-induced liver injury …
Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection.
J Med Invest. 2001 Aug;48(3-4):190-7.
J Med Invest. 2001.
PMID: 11694959
Gastric pit cells express mitogen oxidase1 (Mox1) and essential components for the phagocyte NADPH oxidase (p67-, p47-, p40-, and p22-phoxes). Helicobacter pylori (Hp) lipopolysaccharide (LPS) is a potent up-regulator of the Mox 1 oxidase. ...Hp …
Gastric pit cells express mitogen oxidase1 (Mox1) and essential components for the phagocyte NADPH oxidase (p67-, p47-, …
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