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Sex differences in monocyte activation in systemic lupus erythematosus (SLE).
Jiang W, Zhang L, Lang R, Li Z, Gilkeson G. Jiang W, et al. PLoS One. 2014 Dec 8;9(12):e114589. doi: 10.1371/journal.pone.0114589. eCollection 2014. PLoS One. 2014. PMID: 25485543 Free PMC article.
In the current project, we investigated sex differences in monocyte activation and its implications in SLE disease pathogenesis. ...These sex differences may allow persistent systemic inflammation and resultant enhanced S
In the current project, we investigated sex differences in monocyte activation and its implications in SLE
Intestinal macrophages in mucosal immunity and their role in systemic lupus erythematosus disease.
Pan F, Tang W, Zhou Z, Gilkeson G, Lang R, Jiang W. Pan F, et al. Lupus. 2018 Oct;27(12):1898-1902. doi: 10.1177/0961203318797417. Epub 2018 Sep 17. Lupus. 2018. PMID: 30223707 Free PMC article. Review.
Although mucosal macrophages produce inflammatory cytokines in response to pathogens, the perturbations in innate immune signaling pathway have been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). In this review, we focus …
Although mucosal macrophages produce inflammatory cytokines in response to pathogens, the perturbations in innate immune signaling pathway h …
Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).
Jiang W, Gilkeson G. Jiang W, et al. J Immunother Appl. 2014 Mar 7;1:1. doi: 10.7243/2055-2394-1-1. J Immunother Appl. 2014. PMID: 25309746 Free PMC article.
Whether estrogen has a direct or indirect effect on TLR responsiveness by immune cells is not clear. There is evidence of a role of TLR4 in SLE disease pathogenesis, such as the kidney damage, the induction of CD40 and autoantibodies, the suppression of regulatory T cells, …
Whether estrogen has a direct or indirect effect on TLR responsiveness by immune cells is not clear. There is evidence of a role of TLR4 in …
Fc-gamma receptor expression profile in a North-Indian cohort of pediatric-onset systemic lupus erythematosus: An observational study.
Williams V, Rawat A, Vignesh P, Shandilya JK, Gupta A, Singh S. Williams V, et al. Int J Rheum Dis. 2019 Mar;22(3):449-457. doi: 10.1111/1756-185X.13403. Epub 2018 Nov 6. Int J Rheum Dis. 2019. PMID: 30399647
BACKGROUND: Polymorphisms in the Fcgamma-receptor (FcgammaR) have been associated with increased susceptibility to systemic lupus erythematosus (SLE). There is a paucity of data on FcgammaR expression pattern in pediatric subjects with SLE. ...D …
BACKGROUND: Polymorphisms in the Fcgamma-receptor (FcgammaR) have been associated with increased susceptibility to systemic lupus
Disease-associated and patient-specific immune cell signatures in juvenile-onset systemic lupus erythematosus: patient stratification using a machine-learning approach.
Robinson GA, Peng J, Dönnes P, Coelewij L, Naja M, Radziszewska A, Wincup C, Peckham H, Isenberg DA, Ioannou Y, Pineda-Torra I, Ciurtin C, Jury EC. Robinson GA, et al. Lancet Rheumatol. 2020 Jul 29;2(8):e485-e496. doi: 10.1016/S2665-9913(20)30168-5. eCollection 2020 Aug. Lancet Rheumatol. 2020. PMID: 32818204 Free PMC article.
BACKGROUND: Juvenile-onset systemic lupus erythematosus (SLE) is a rare autoimmune rheumatic disease characterised by more severe disease manifestations, earlier damage accrual, and higher mortality than in adult-onset SLE. ...Notably, CD8 T-cel …
BACKGROUND: Juvenile-onset systemic lupus erythematosus (SLE) is a rare autoimmune rheumatic disease characteris …
Monocyte receptors for the Fc portion of IgG are increased in systemic lupus erythematosus.
Fries LF, Mullins WW, Cho KR, Plotz PH, Frank MM. Fries LF, et al. J Immunol. 1984 Feb;132(2):695-700. J Immunol. 1984. PMID: 6228597
Defective clearance of IgG-sensitized particles has been documented in systemic lupus erythematosus (SLE). This defect may be of pathogenetic significance because it allows the prolonged circulation of endogenous immune complexes with subsequent tissue …
Defective clearance of IgG-sensitized particles has been documented in systemic lupus erythematosus (SLE). This …
Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21.
Harris VM, Harley ITW, Kurien BT, Koelsch KA, Scofield RH. Harris VM, et al. Front Immunol. 2019 Apr 2;10:578. doi: 10.3389/fimmu.2019.00578. eCollection 2019. Front Immunol. 2019. PMID: 31001245 Free PMC article.
Background: CXorf21 and SLC15a4 both contain risk alleles for systemic lupus erythematosus (SLE) and Sjogren's syndrome (pSS). The former escapes X inactivation. ...The lower pH levels observed in specific female immune cells provide a function …
Background: CXorf21 and SLC15a4 both contain risk alleles for systemic lupus erythematosus (SLE) and Sjogren' …
Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis.
Harris VM, Koelsch KA, Kurien BT, Harley ITW, Wren JD, Harley JB, Scofield RH. Harris VM, et al. Front Immunol. 2019 Oct 21;10:2160. doi: 10.3389/fimmu.2019.02160. eCollection 2019. Front Immunol. 2019. PMID: 31695690 Free PMC article.
Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjogren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactiva …
Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increas …
Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors.
Asanuma Y, Chung CP, Oeser A, Shintani A, Stanley E, Raggi P, Stein CM. Asanuma Y, et al. J Rheumatol. 2006 Mar;33(3):539-45. Epub 2006 Feb 1. J Rheumatol. 2006. PMID: 16463434
OBJECTIVE: . To examine the hypothesis that patients with systemic lupus erythematosus (SLE) have increased concentrations of interleukin-6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) and that these cytokines are associated with …
OBJECTIVE: . To examine the hypothesis that patients with systemic lupus erythematosus (SLE) have increased conc …
Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis.
Lyons PA, McKinney EF, Rayner TF, Hatton A, Woffendin HB, Koukoulaki M, Freeman TC, Jayne DR, Chaudhry AN, Smith KG. Lyons PA, et al. Ann Rheum Dis. 2010 Jun;69(6):1208-13. doi: 10.1136/ard.2009.108043. Epub 2009 Oct 7. Ann Rheum Dis. 2010. PMID: 19815495 Free PMC article.
OBJECTIVE: To optimise a strategy for identifying gene expression signatures differentiating systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis that provide insight into disease pathogenesis and identify bi …
OBJECTIVE: To optimise a strategy for identifying gene expression signatures differentiating systemic lupus erythematosus
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