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Signal transduction involved in MCP-1-mediated monocytic transendothelial migration.
Cambien B, Pomeranz M, Millet MA, Rossi B, Schmid-Alliana A. Cambien B, et al. Blood. 2001 Jan 15;97(2):359-66. doi: 10.1182/blood.v97.2.359. Blood. 2001. PMID: 11154209 Free article.
Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and T lymphocytes. The MonoMac6 cell line was used to examine MCP-1 receptor-mediated signal transduction events in relation to MC
Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and T lymphocytes. The MonoM
LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.
Anand AR, Bradley R, Ganju RK. Anand AR, et al. Mol Immunol. 2009 Feb;46(5):962-8. doi: 10.1016/j.molimm.2008.09.022. Epub 2008 Oct 26. Mol Immunol. 2009. PMID: 18954908 Free PMC article.
However, the mechanism involved in LPS-induced MCP-1 production in endothelial cells is not well understood. Using human microvascular endothelial cells (HMVEC), we analyzed the involvement of the non-receptor tyrosine kinase, Pyk2, in LPS-mediated
However, the mechanism involved in LPS-induced MCP-1 production in endothelial cells is not well understood. Using huma …
Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migration.
Ryu JW, Hong KH, Maeng JH, Kim JB, Ko J, Park JY, Lee KU, Hong MK, Park SW, Kim YH, Han KH. Ryu JW, et al. Arterioscler Thromb Vasc Biol. 2004 May;24(5):864-70. doi: 10.1161/01.ATV.0000125705.28058.eb. Epub 2004 Mar 11. Arterioscler Thromb Vasc Biol. 2004. PMID: 15016641
Here we investigated whether UCP2 regulates expression of genes involved in monocyte recruitment. METHODS AND RESULTS: UCP2 overexpression in THP1 monocytes, which induced a 10-fold increase in mitochondrial UCP2 protein levels, reduced steady-state level of …
Here we investigated whether UCP2 regulates expression of genes involved in monocyte recruitment. METHODS AND RESULTS: UCP2 ov …
Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase-deficient mice.
Zhao T, Ding X, Yan C, Du H. Zhao T, et al. J Biol Chem. 2017 Nov 24;292(47):19198-19208. doi: 10.1074/jbc.M116.773093. Epub 2017 Sep 18. J Biol Chem. 2017. PMID: 28924047 Free PMC article.
Here we report that lal(-/-) ECs facilitated in vivo tumor angiogenesis, growth, and metastasis, largely by stimulating tumor cell proliferation, migration, adhesion, and transendothelial migration via increased expression of IL-6 and monocyte chemoatt …
Here we report that lal(-/-) ECs facilitated in vivo tumor angiogenesis, growth, and metastasis, largely by stimulating tumor cell prolifera …
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation.
Haudek SB, Gupta D, Dewald O, Schwartz RJ, Wei L, Trial J, Entman ML. Haudek SB, et al. Cardiovasc Res. 2009 Aug 1;83(3):511-8. doi: 10.1093/cvr/cvp135. Epub 2009 Apr 30. Cardiovasc Res. 2009. PMID: 19406912 Free PMC article.
The differentiation of human monocytes into fibroblasts in vitro occurs after transendothelial migration (TEM) induced by monocyte chemoattractant protein 1 (MCP-1). ...We also performed in vitro assays in which human peripheral blood mon …
The differentiation of human monocytes into fibroblasts in vitro occurs after transendothelial migration (TEM) induced …
Monocyte chemoattractant protein-1 induces scavenger receptor expression and monocyte differentiation into foam cells.
Tabata T, Mine S, Kawahara C, Okada Y, Tanaka Y. Tabata T, et al. Biochem Biophys Res Commun. 2003 May 30;305(2):380-5. doi: 10.1016/s0006-291x(03)00771-x. Biochem Biophys Res Commun. 2003. PMID: 12745086
Our results showed that: (1) MCP-1 increased the expression of CD36 SCR by flow cytometric analysis. (2) MCP-1 increased incorporation of 125I-labeled ox-LDL and oil red O staining. (3) MCP-1 and ox-LDL enhanced in vitro transendotheli
Our results showed that: (1) MCP-1 increased the expression of CD36 SCR by flow cytometric analysis. (2) MCP-1 i …