Signaling pathways for monocyte chemoattractant protein 1-mediated extracellular signal-regulated kinase activation.
Mol Pharmacol. 2003.
PMID: 12920215
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Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression.
Nat Commun. 2024 Mar 5;15(1):1987. doi: 10.1038/s41467-024-46193-z.
Nat Commun. 2024.
PMID: 38443336
Free PMC article.
Combined profiling and functional studies demonstrate that lactate dehydrogenase A (LDHA)-directed extracellular signal-regulated kinase (ERK) pathway activates yes-associated protein 1 (YAP1)/ signal transducer and activator …
Combined profiling and functional studies demonstrate that lactate dehydrogenase A (LDHA)-directed extracellular signal-reg …
Signaling pathways for monocyte chemoattractant protein 1-mediated extracellular signal-regulated kinase activation.
Mol Pharmacol. 2003 Sep;64(3):773-82. doi: 10.1124/mol.64.3.773.
Mol Pharmacol. 2003.
PMID: 12920215
G protein-coupled receptors (GPCRs) initiate diverse down-stream signaling events in response to ligand stimulation, as rapid activation of the extracellular signal-regulated kinase ERK1 and ERK2. The chemokine monocyte c …
G protein-coupled receptors (GPCRs) initiate diverse down-stream signaling events in response to ligand stimulation, as rapid acti …
Zerumin A attenuates the inflammatory responses in LPS-stimulated H9c2 cardiomyoblasts.
J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22777. Epub 2021 Mar 23.
J Biochem Mol Toxicol. 2021.
PMID: 33755281
In addition, ZA significantly ameliorated LPS-elicited overexpression of pro-inflammatory chemokines and cytokines such as monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNF- alpha), interferon-gamma (IFN-gamma), and interleuk …
In addition, ZA significantly ameliorated LPS-elicited overexpression of pro-inflammatory chemokines and cytokines such as monocyte …
Adipocytokines leptin and adiponectin function as mast cell activity modulators.
Immunology. 2019 Sep;158(1):3-18. doi: 10.1111/imm.13090. Epub 2019 Jul 10.
Immunology. 2019.
PMID: 31220342
Free PMC article.
We established that leptin, but not adiponectin, stimulates MCs to release of histamine as well as to generation of cysteinyl leukotrienes (cysLTs) and chemokine CCL2. We also found that both adipocytokines affect mRNA expression of various cytokines/chemokines. ... …
We established that leptin, but not adiponectin, stimulates MCs to release of histamine as well as to generation of cysteinyl leukotrienes ( …
Mitogen-Activated Protein Kinases Mediate Adventitial Fibroblast Activation and Neointima Formation via GATA4/Cyclin D1 Axis.
Cardiovasc Drugs Ther. 2024 Jun;38(3):527-538. doi: 10.1007/s10557-023-07428-1. Epub 2023 Jan 18.
Cardiovasc Drugs Ther. 2024.
PMID: 36652042
PURPOSE: Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular diseases. ...RESULTS: Phosphorylation of p38, c-Jun N-terminal kinase (JNK), and extracellular regulated kinases …
PURPOSE: Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular …
Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells.
Ocul Immunol Inflamm. 2022 May 19;30(4):789-800. doi: 10.1080/09273948.2020.1833224. Epub 2020 Nov 20.
Ocul Immunol Inflamm. 2022.
PMID: 33215957
GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1beta, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE-19/primary RPE cells. Moreover, GSSSG prevented the activation of the nuclear factor-kappa B p65 subunit, and promoted the activat …
GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1beta, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE- …
Regulation of immune response by S-1-propenylcysteine through autophagy-mediated protein degradation.
Exp Ther Med. 2020 Feb;19(2):1570-1573. doi: 10.3892/etm.2019.8392. Epub 2019 Dec 27.
Exp Ther Med. 2020.
PMID: 32010341
Free PMC article.
Review.
The degradation of MyD88 inhibits the TLR signaling pathway, including the phosphorylation of interleukin 1 receptor associated kinase 4 (IRAK4) and nuclear factor (NF)-kappaB p65 in vitro, and eventually leads to the inhibition of interleukin (IL)-6 producti …
The degradation of MyD88 inhibits the TLR signaling pathway, including the phosphorylation of interleukin 1 receptor associate …
Granzyme K activates protease-activated receptor-1.
PLoS One. 2011;6(6):e21484. doi: 10.1371/journal.pone.0021484. Epub 2011 Jun 30.
PLoS One. 2011.
PMID: 21760880
Free PMC article.
In the context of acute lung inflammation, we hypothesized that GrK induces pro-inflammatory cytokine release through the activation of protease-activated receptors. The direct effect of extracellular GrK on PAR activation, intracellular signaling …
In the context of acute lung inflammation, we hypothesized that GrK induces pro-inflammatory cytokine release through the activation …
Celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats.
Int J Nanomedicine. 2016 Nov 18;11:6135-6148. doi: 10.2147/IJN.S117425. eCollection 2016.
Int J Nanomedicine. 2016.
PMID: 27920521
Free PMC article.
The expression of hypoxia-inducible factors-1alpha (HIF-1alpha), nuclear factor-kappa B p65 (NF-kappaB p65), phospho-nuclear factor-kappa B p65 (phospho-NF-kappaB p65), p38 mitogen-activated protein kinase (p38 MAPK), phospho-p38 MAPK, extracellular signal …
The expression of hypoxia-inducible factors-1alpha (HIF-1alpha), nuclear factor-kappa B p65 (NF-kappaB p65), phospho-nuclear factor-kappa B …
Pro-atherogenic activation of A7r5 cells induced by the oxLDL/beta2GPI/anti-beta2GPI complex.
Int J Mol Med. 2018 Oct;42(4):1955-1966. doi: 10.3892/ijmm.2018.3805. Epub 2018 Aug 2.
Int J Mol Med. 2018.
PMID: 30085340
Free PMC article.
The results revealed that the oxLDL/beta2GPI/anti-beta2GPI complex treatment significantly (P<0.05 vs. the media, oxLDL, oxLDL/beta2GPI and beta2GPI/anti-beta2GPI groups) enhanced the pro-atherogenic activation of A7r5 cells, including intracellular lipid loading, Acyl- …
The results revealed that the oxLDL/beta2GPI/anti-beta2GPI complex treatment significantly (P<0.05 vs. the media, oxLDL, oxLDL/beta2GPI a …
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