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Year Number of Results
2000 2
2001 9
2002 4
2003 3
2004 8
2005 7
2006 6
2007 6
2008 12
2009 17
2010 12
2011 10
2012 10
2013 13
2014 11
2015 12
2016 13
2017 10
2018 14
2019 12
2020 8
2021 2
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Pro-atherogenic activation of A7r5 cells induced by the oxLDL/beta2GPI/anti-beta2GPI complex.
Wang T, Ouyang H, Zhou H, Xia L, Wang X, Wang T. Wang T, et al. Int J Mol Med. 2018 Oct;42(4):1955-1966. doi: 10.3892/ijmm.2018.3805. Epub 2018 Aug 2. Int J Mol Med. 2018. PMID: 30085340 Free PMC article.
The results revealed that the oxLDL/beta2GPI/anti-beta2GPI complex treatment significantly (P<0.05 vs. the media, oxLDL, oxLDL/beta2GPI and beta2GPI/anti-beta2GPI groups) enhanced the pro-atherogenic activation of A7r5 cells, including intracellular lipid loading, Acyl- …
The results revealed that the oxLDL/beta2GPI/anti-beta2GPI complex treatment significantly (P<0.05 vs. the media, oxLDL, oxLDL/beta2GPI a …
WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages.
Lee GT, Kwon SJ, Kim J, Kwon YS, Lee N, Hong JH, Jamieson C, Kim WJ, Kim IY. Lee GT, et al. Br J Cancer. 2018 Mar 6;118(5):670-678. doi: 10.1038/bjc.2017.451. Epub 2018 Jan 30. Br J Cancer. 2018. PMID: 29381686 Free PMC article.
RESULTS: WNT5A was associated with increased expression of chemokine ligand 2 (CCL2) in the human CaP cell line, LNCaP. Mechanistically, this induction of CCL2 by WNT5A is likely to be mediated via the mitogen-activated protein kinase
RESULTS: WNT5A was associated with increased expression of chemokine ligand 2 (CCL2) in the human CaP cell line, LNCaP. Mechan …
Statins decrease leptin expression in human white adipocytes.
Singh P, Zhang Y, Sharma P, Covassin N, Soucek F, Friedman PA, Somers VK. Singh P, et al. Physiol Rep. 2018 Jan;6(2):e13566. doi: 10.14814/phy2.13566. Physiol Rep. 2018. PMID: 29372612 Free PMC article.
We show that treatment of white adipocytes with simvastatin and atorvastatin decreases leptin mRNA expression (simvastatin: P = 0.008, atorvastatin: P = 0.03) and leptin secretion (simvastatin: P = 0.0001, atorvastatin: P = 0.0001). Both simvastatin and atorvastatin mediate
We show that treatment of white adipocytes with simvastatin and atorvastatin decreases leptin mRNA expression (simvastatin: P = 0.008, atorv …
Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF.
Gao Y, Hou R, Liu F, Liu H, Fei Q, Han Y, Cai R, Peng C, Qi Y. Gao Y, et al. J Cell Biochem. 2018 Jan;119(1):837-849. doi: 10.1002/jcb.26248. Epub 2017 Aug 3. J Cell Biochem. 2018. PMID: 28657665
A mechanism study showed that OBA significantly suppressed p38-mediated AP-1 signaling by stabilizing the mRNA of mitogen-activated protein kinase phosphatase 1 (MKP-1), thus prolonging the expression time of the MKP-1
A mechanism study showed that OBA significantly suppressed p38-mediated AP-1 signaling by stabilizing the mRNA of mitog …
P2Y(14) receptor is functionally expressed in satellite glial cells and mediates interleukin-1beta and chemokine CCL2 secretion.
Lin J, Liu F, Zhang YY, Song N, Liu MK, Fang XY, Liao DQ, Zhou C, Wang H, Shen JF. Lin J, et al. J Cell Physiol. 2019 Nov;234(11):21199-21210. doi: 10.1002/jcp.28726. Epub 2019 Apr 29. J Cell Physiol. 2019. PMID: 31032956
Immunofluorescence and western blot showed that UDP-glucose treatment upregulated glial fibrillary acid protein, a common marker for glial activation. Extracellular UDP-glucose enhanced the phosphorylation of extracellular signal-regulated
Immunofluorescence and western blot showed that UDP-glucose treatment upregulated glial fibrillary acid protein, a common marker for …
Nuclear Translocation of p65 is Controlled by Sec6 via the Degradation of IκBα.
Tanaka T, Iino M. Tanaka T, et al. J Cell Physiol. 2016 Mar;231(3):719-30. doi: 10.1002/jcp.25122. J Cell Physiol. 2016. PMID: 26247921
The 90 kDa ribosomal S6 kinase (p90RSK) family, which is serine/threonine kinases, is phosphorylated by extracellular signal-regulated kinase1/2 (ERK1/2) and is related to NF-kappaB pathways. ...Furthermore, the binding of p65 and cAMP re …
The 90 kDa ribosomal S6 kinase (p90RSK) family, which is serine/threonine kinases, is phosphorylated by extracellular
Retinoic acid inducible gene-I slows down cellular senescence through negatively regulating the integrin beta3/p38 MAPK pathway.
Zhao J, Jiang X, Yan L, Lin J, Guo H, Yu S, Ye B, Zhu J, Zhang W. Zhao J, et al. Cell Cycle. 2019 Dec;18(23):3378-3392. doi: 10.1080/15384101.2019.1677074. Epub 2019 Oct 9. Cell Cycle. 2019. PMID: 31595820 Free PMC article.
By performing a transcriptome analysis, we identified integrins at the intersections of biological pathways affected by Rig-I. Among these, integrin beta3 was negatively regulated by Rig-I, and significantly upregulated with the occurrence of senescence. ...Taken to …
By performing a transcriptome analysis, we identified integrins at the intersections of biological pathways affected by Rig-I. Among …
Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors.
Guan R, Xu X, Chen M, Hu H, Ge H, Wen S, Zhou S, Pi R. Guan R, et al. Eur J Med Chem. 2013;70:613-22. doi: 10.1016/j.ejmech.2013.10.048. Epub 2013 Oct 25. Eur J Med Chem. 2013. PMID: 24211637 Review.
RhoA/Rho-kinase pathway plays a pivotal role in numerous fundamental cellular functions including contraction, motility, proliferation, differentiation and apoptosis. ...The inhibitors of Rho kinase have been extensively studied since the Rho/Rho-kinase
RhoA/Rho-kinase pathway plays a pivotal role in numerous fundamental cellular functions including contraction, motility, proli …
MCP-1-induced ERK/GSK-3beta/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells.
Li S, Lu J, Chen Y, Xiong N, Li L, Zhang J, Yang H, Wu C, Zeng H, Liu Y. Li S, et al. Cell Mol Immunol. 2017 Jul;14(7):621-630. doi: 10.1038/cmi.2015.106. Epub 2016 Mar 21. Cell Mol Immunol. 2017. PMID: 26996066 Free PMC article.
Monocyte chemoattractant protein-1 (MCP-1) is a chemotactic cytokine that can bind to its receptor cysteine-cysteine chemokine receptor 2 (CCR2) and plays an important role in breast cancer cell metastasis. ...Moreover, MCP-1 treat
Monocyte chemoattractant protein-1 (MCP-1) is a chemotactic cytokine that can bind to its receptor cystei
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
Qu Z, Chen Y, Luo ZH, Shen XL, Hu YJ. Qu Z, et al. J Pharm Pharmacol. 2020 Mar;72(3):385-395. doi: 10.1111/jphp.13219. Epub 2019 Dec 22. J Pharm Pharmacol. 2020. PMID: 31867739
KEY FINDINGS: In BV2 cells, pretreatment with 7MF antagonized LPS-induced production of inflammatory factors IL-6, tumour necrosis factor-alpha (TNF-alpha), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1) …
KEY FINDINGS: In BV2 cells, pretreatment with 7MF antagonized LPS-induced production of inflammatory factors IL-6, tumour necrosis factor-al …
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