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Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation.
Mukaro VR, Quach A, Gahan ME, Boog B, Huang ZH, Gao X, Haddad C, Mahalingam S, Hii CS, Ferrante A. Mukaro VR, et al. Nat Commun. 2018 Apr 10;9(1):1365. doi: 10.1038/s41467-018-03640-y. Nat Commun. 2018. PMID: 29636466 Free PMC article.
Here, we show that TNF(70-80) binds to the TNF receptor, activating p38 MAP kinase through TNF receptor-associated factor 2. Using truncated TNFR mutants, we identify the sequence in TNFRI which enables p38 activation by TNF(70-80). Peptides wit …
Here, we show that TNF(70-80) binds to the TNF receptor, activating p38 MAP kinase through TNF receptor-associated f …
TNF-alpha augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell.
Wang Z, Ao X, Shen Z, Ao L, Wu X, Pu C, Guo W, Xing W, He M, Yuan H, Yu J, Li L, Xu X. Wang Z, et al. Int J Biol Sci. 2021 Jun 26;17(11):2683-2702. doi: 10.7150/ijbs.61350. eCollection 2021. Int J Biol Sci. 2021. PMID: 34345201 Free PMC article.
Tumor necrosis factor-alpha (TNF-alpha), a main inflammation mediator within tumor microenvironment, affects tumor development by inducing multiple chemokines to establish a complex network. ...According to this study, TNF-alpha ac …
Tumor necrosis factor-alpha (TNF-alpha), a main inflammation mediator within tumor microenvironmen …