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1987 1
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2001 2
2002 2
2003 3
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Soluble CD14 activates monocytic cells independently of lipopolysaccharide.
Landmann R, Link S, Sansano S, Rajacic Z, Zimmerli W. Landmann R, et al. Infect Immun. 1998 May;66(5):2264-71. doi: 10.1128/IAI.66.5.2264-2271.1998. Infect Immun. 1998. PMID: 9573116 Free PMC article.
The glycoprotein CD14 acts as a receptor for lipopolysaccharide (LPS), either when anchored in the myeloid cell membrane (mCD14) or as a soluble molecule (sCD14) in serum. sCD14-LPS complexes activate cells devoid of mCD14. However, the r …
The glycoprotein CD14 acts as a receptor for lipopolysaccharide (LPS), either when anchored in the myeloid cell membran …
Plasma levels of soluble CD14 independently predict mortality in HIV infection.
Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE, Pedersen C, Ruxrungtham K, Lewin SR, Emery S, Neaton JD, Brenchley JM, Deeks SG, Sereti I, Douek DC; INSIGHT SMART Study Group. Sandler NG, et al. J Infect Dis. 2011 Mar 15;203(6):780-90. doi: 10.1093/infdis/jiq118. Epub 2011 Jan 20. J Infect Dis. 2011. PMID: 21252259 Free PMC article. Clinical Trial.
BACKGROUND: Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to systemic immune activation, which is an independent predictor of HIV disease progression. ...METHODS: This nes …
BACKGROUND: Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that …
Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14.
Ma CY, Chang WE, Shi GY, Chang BY, Cheng SE, Shih YT, Wu HL. Ma CY, et al. J Immunol. 2015 Feb 15;194(4):1905-15. doi: 10.4049/jimmunol.1400923. Epub 2015 Jan 21. J Immunol. 2015. PMID: 25609841 Free article.
CD14, a multiligand pattern-recognition receptor, is involved in the activation of many TLRs. ...The anti-inflammatory activity of rTMD23 was independent of activated protein C. We also found that rTMD23 interacted with the soluble and me
CD14, a multiligand pattern-recognition receptor, is involved in the activation of many TLRs. ...The anti-inflammatory acti
Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1beta via CD36 and Nicotinic Acetylcholine Receptors.
Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V. Siebers K, et al. Front Immunol. 2018 Apr 25;9:877. doi: 10.3389/fimmu.2018.00877. eCollection 2018. Front Immunol. 2018. PMID: 29922281 Free PMC article.
Both, native and oxidized AAT are active, suggesting that the inhibition of IL-1beta release is independent of the anti-elastase activity of AAT. Signaling of AAT in monocytic cells involves the lipid scavenger receptor CD36, calcium-independ
Both, native and oxidized AAT are active, suggesting that the inhibition of IL-1beta release is independent of the anti-elasta …
beta-Nicotinamide Adenine Dinucleotide (beta-NAD) Inhibits ATP-Dependent IL-1beta Release from Human Monocytic Cells.
Hiller SD, Heldmann S, Richter K, Jurastow I, Küllmar M, Hecker A, Wilker S, Fuchs-Moll G, Manzini I, Schmalzing G, Kummer W, Padberg W, McIntosh JM, Damm J, Zakrzewicz A, Grau V. Hiller SD, et al. Int J Mol Sci. 2018 Apr 10;19(4):1126. doi: 10.3390/ijms19041126. Int J Mol Sci. 2018. PMID: 29642561 Free PMC article.
IL-1beta was measured in cell culture supernatants. The roles of P2Y receptors, nicotinic acetylcholine receptors (nAChRs), and Ca(2+)-independent phospholipase A2 (iPLA2beta, PLA2G6) were investigated using specific inhibitors and gene-silencing. ...I …
IL-1beta was measured in cell culture supernatants. The roles of P2Y receptors, nicotinic acetylcholine receptors (nACh …
Lipopolysaccharide stimulates p38-dependent induction of antiviral genes in neutrophils independently of paracrine factors.
Malcolm KC, Worthen GS. Malcolm KC, et al. J Biol Chem. 2003 May 2;278(18):15693-701. doi: 10.1074/jbc.M212033200. Epub 2003 Feb 20. J Biol Chem. 2003. PMID: 12595530 Free article.
Lipopolysaccharide-stimulated neutrophils do not phosphorylate the interferon-associated transcription factors signal transducer and activator of transcription-1 and -3, and medium from lipopolysaccharide-stimulated cells was unable to induce MX1 gene
Lipopolysaccharide-stimulated neutrophils do not phosphorylate the interferon-associated transcription factors signal transducer and
Promoter polymorphism in the CD14 gene and concentration of soluble CD14 in patients with in-stent restenosis after elective coronary stenting.
Shimada K, Miyauchi K, Mokuno H, Watanabe Y, Iwama Y, Shigekiyo M, Matsumoto M, Okazaki S, Tanimoto K, Kurata T, Sato H, Daida H. Shimada K, et al. Int J Cardiol. 2004 Mar;94(1):87-92. doi: 10.1016/j.ijcard.2003.05.007. Int J Cardiol. 2004. PMID: 14996480
Monocytes/macrophages and neutrophils are activated by lipopolysaccharide (LPS) via CD14. Endothelial cells and smooth muscle cells are also stimulated by soluble CD14 (sCD14)-LPS complexes. ...
Monocytes/macrophages and neutrophils are activated by lipopolysaccharide (LPS) via CD14. Endothelial cells
Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients.
Trøseid M, Nestvold TK, Nielsen EW, Thoresen H, Seljeflot I, Lappegård KT. Trøseid M, et al. Metab Syndr Relat Disord. 2015 Apr;13(3):119-24. doi: 10.1089/met.2014.0111. Epub 2015 Jan 6. Metab Syndr Relat Disord. 2015. PMID: 25562385
BACKGROUND: Chronic endotoxemia has been proposed to contribute to obesity-related complications. We aimed to investigate the potential impact of lipopolysaccharide (LPS) and subsequent monocyte activation measured as soluble CD14 (sCD14) on mar …
BACKGROUND: Chronic endotoxemia has been proposed to contribute to obesity-related complications. We aimed to investigate the potential impa …
CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserine.
Devitt A, Pierce S, Oldreive C, Shingler WH, Gregory CD. Devitt A, et al. Cell Death Differ. 2003 Mar;10(3):371-82. doi: 10.1038/sj.cdd.4401168. Cell Death Differ. 2003. PMID: 12700637 Free article.
Compared with phosphatidylcholine and phosphatidylethanolamine, PS was the least active phospholipid binding to human monocyte-derived macrophages and showed no specificity for soluble or membrane-anchored CD14. Significantly, PS-containing liposomes f …
Compared with phosphatidylcholine and phosphatidylethanolamine, PS was the least active phospholipid binding to human monocyte
Microinflammation and endothelial damage in hemodialysis.
Merino A, Nogueras S, Buendía P, Ojeda R, Carracedo J, Ramirez-Chamond R, Martin-Malo A, Aljama P. Merino A, et al. Contrib Nephrol. 2008;161:83-88. doi: 10.1159/000130412. Contrib Nephrol. 2008. PMID: 18451662 Review.
METHODS: To study the effect of microinflammation on endothelial cell injury we have developed an experimental co-culture model in which isolated CD14+/CD16+ cells were seeded in 24-well tissue-culture plates. ...Endothelial injury was characterized measuring …
METHODS: To study the effect of microinflammation on endothelial cell injury we have developed an experimental co-culture model in wh …
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