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The following term was not found in PubMed: taurosporine
Page 1
Synergism between staurosporine and drugs inducing endoplasmic reticulum stress.
Cusinato F, Pighin I, Luciani S, Trevisi L. Cusinato F, et al. Biochem Pharmacol. 2006 May 28;71(11):1562-9. doi: 10.1016/j.bcp.2006.03.003. Epub 2006 Apr 18. Biochem Pharmacol. 2006. PMID: 16620791
Drugs causing endoplasmic reticulum or mitochondrial dysfunction may trigger apoptosis in eukaryotic cells. ...We conclude that staurosporine is more active in cells undergoing endoplasmic reticulum stress. This synergism may warra
Drugs causing endoplasmic reticulum or mitochondrial dysfunction may trigger apoptosis in eukaryotic cells. ...We concl
Novel Thioredoxin reductase 1 inhibitor BS1801 relieves treatment resistance and triggers endoplasmic reticulum stress by elevating reactive oxygen species in glioma.
Chang Y, Chang J, Ji J, Sun J, Hu H, Pang B, Zhang Q, Yin H, Zeng H, Jiang T, Li G, Zeng F. Chang Y, et al. Redox Biol. 2025 Oct;86:103827. doi: 10.1016/j.redox.2025.103827. Epub 2025 Aug 29. Redox Biol. 2025. PMID: 40914135 Free PMC article.
Additionally, BS1801 treatment elevated ROS levels, resulting in glioblastoma cell cycle arrest, endoplasmic reticulum (ER) stress, mitochondrial dysfunction and apoptosis. Meanwhile, BS1801 synergized with TMZ to significantly inhibit glioblastoma cel …
Additionally, BS1801 treatment elevated ROS levels, resulting in glioblastoma cell cycle arrest, endoplasmic reticulum (ER) …
Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma.
Hill DS, Martin S, Armstrong JL, Flockhart R, Tonison JJ, Simpson DG, Birch-Machin MA, Redfern CP, Lovat PE. Hill DS, et al. Clin Cancer Res. 2009 Feb 15;15(4):1192-8. doi: 10.1158/1078-0432.CCR-08-2150. Clin Cancer Res. 2009. PMID: 19228725 Free PMC article.
PURPOSE: Single-agent chemotherapy is largely the treatment of choice for systemic therapy of metastatic melanoma, but survival rates are low, and novel adjuvant and systemic therapies are urgently required. Endoplasmic reticulum (ER) stress is a potential th …
PURPOSE: Single-agent chemotherapy is largely the treatment of choice for systemic therapy of metastatic melanoma, but survival rates are lo …
Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress.
Sato A, Asano T, Okubo K, Isono M, Asano T. Sato A, et al. Oncol Res. 2018 Mar 5;26(2):323-332. doi: 10.3727/096504017X14957929842972. Epub 2017 May 26. Oncol Res. 2018. PMID: 28560953 Free PMC article.
The human immunodeficiency virus (HIV) protease inhibitor nelfinavir acts against malignancies by inducing endoplasmic reticulum (ER) stress. The HIV protease inhibitor ritonavir, on the other hand, not only induces ER stress but also inh …
The human immunodeficiency virus (HIV) protease inhibitor nelfinavir acts against malignancies by inducing endoplasmic reti
Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFalpha-mediated hepatotoxicity.
Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500
Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiation signaling and nuclear factor-erythroid 2 (NF-E2)-related f …
Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed th …
A metabolic perspective of late onset Alzheimer's disease.
Ettcheto M, Cano A, Busquets O, Manzine PR, Sánchez-López E, Castro-Torres RD, Beas-Zarate C, Verdaguer E, García ML, Olloquequi J, Auladell C, Folch J, Camins A. Ettcheto M, et al. Pharmacol Res. 2019 Jul;145:104255. doi: 10.1016/j.phrs.2019.104255. Epub 2019 May 7. Pharmacol Res. 2019. PMID: 31075308 Free article. Review.
In this line of research, the relative contribution of soluble Abeta oligomers to neuronal damage associated with metabolic disorders such as Type 2 Diabetes Mellitus (T2DM) and obesity is being actively investigated. Some authors have proposed the endoplasmic reticulum
In this line of research, the relative contribution of soluble Abeta oligomers to neuronal damage associated with metabolic disorders such a …
Synergistic Effects of Commonly Used Intensive Care Unit Drugs and High Temperature on Skeletal Muscle at the Cellular and Tissue Levels.
Sugiki K, Takahashi H, Shimizu T. Sugiki K, et al. Anesthesiology. 2025 Oct 1;143(4):999-1014. doi: 10.1097/ALN.0000000000005630. Epub 2025 Jun 20. Anesthesiology. 2025. PMID: 40540542 Free PMC article.
To investigate the effects of the drug treatments, cell viability, lactate dehydrogenase activity, caspase activity, and endoplasmic reticulum (ER) stress were analyzed. Conformational changes in myotubes and functional changes in contractile muscle tissue we …
To investigate the effects of the drug treatments, cell viability, lactate dehydrogenase activity, caspase activity, and endoplasmic
Endoplasmic reticulum stress in non-small cell lung cancer: a review of therapeutic agents, mechanistic insights, and implications for therapy.
Luo Q, Gao X, Meng P, Qi X, Wang W, Li S, Duan L. Luo Q, et al. Front Cell Dev Biol. 2025 Dec 16;13:1693023. doi: 10.3389/fcell.2025.1693023. eCollection 2025. Front Cell Dev Biol. 2025. PMID: 41476609 Free PMC article. Review.
Non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with therapy resistance significantly hindering treatment efficacy. This review explores the role of endoplasmic reticulum (ER) stress and the unfolded protein response (U …
Non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with therapy resistance significantly hindering trea …
Combating multidrug resistance and metastasis of breast cancer by endoplasmic reticulum stress and cell-nucleus penetration enhanced immunochemotherapy.
Jiang W, Chen L, Guo X, Cheng C, Luo Y, Wang J, Wang J, Liu Y, Cao Y, Li P, Wang Z, Ran H, Zhou Z, Ren J. Jiang W, et al. Theranostics. 2022 Mar 21;12(6):2987-3006. doi: 10.7150/thno.71693. eCollection 2022. Theranostics. 2022. PMID: 35401832 Free PMC article.
On the other hand, efflux proteins, especially P-glycoprotein (P-gp), can recognize and promote the efflux of drugs from tumor cells. Methods: In this study, silver nanoparticles (Ag NPs) and peptide- functionalized doxorubicin ((P)DOX) were used to prepare a theranostic n …
On the other hand, efflux proteins, especially P-glycoprotein (P-gp), can recognize and promote the efflux of drugs from tumor cells. …
Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers.
Kou X, Fan J, Chen N. Kou X, et al. Anticancer Agents Med Chem. 2017;17(12):1610-1616. doi: 10.2174/1871521409666170412130529. Anticancer Agents Med Chem. 2017. PMID: 28403777 Review.
In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducin
In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments …
50 results