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Targeting the monocytic ubiquitin system with extracellular ubiquitin.
Majetschak M, Ponelies N, Hirsch T. Majetschak M, et al. Immunol Cell Biol. 2006 Feb;84(1):59-65. doi: 10.1111/j.1440-1711.2005.01399.x. Epub 2005 Nov 7. Immunol Cell Biol. 2006. PMID: 16277638
These results suggest that the monocytic ubiquitin system can be targeted with physiologically relevant concentrations of extracellular ubiquitin during inflammation. This concept could provide a simple explanation for a multitude of e
These results suggest that the monocytic ubiquitin system can be targeted with physiologically relevant concentr …
Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors.
Guan R, Xu X, Chen M, Hu H, Ge H, Wen S, Zhou S, Pi R. Guan R, et al. Eur J Med Chem. 2013;70:613-22. doi: 10.1016/j.ejmech.2013.10.048. Epub 2013 Oct 25. Eur J Med Chem. 2013. PMID: 24211637 Review.
The pathway is also involved in the development of many diseases such as vasospasm, pulmonary hypertension, cancer and central nervous systems (CNS) disorders. The inhibitors of Rho kinase have been extensively studied since the Rho/Rho-kinase pathway was verified as a …
The pathway is also involved in the development of many diseases such as vasospasm, pulmonary hypertension, cancer and central nervous sy
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway.
Watson RO, Manzanillo PS, Cox JS. Watson RO, et al. Cell. 2012 Aug 17;150(4):803-15. doi: 10.1016/j.cell.2012.06.040. Cell. 2012. PMID: 22901810 Free PMC article.
During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can limit replication, but the mechanism of autophagy targeting and its role in natural infection remain unclear. Here we show that phagosomal permeabilizatio …
During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can limit replication, bu …
Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
Wiejak J, Dunlop J, Mackay SP, Yarwood SJ. Wiejak J, et al. Biochem J. 2013 Sep 1;454(2):283-93. doi: 10.1042/BJ20130481. Biochem J. 2013. PMID: 23782265 Free PMC article.
Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce S …
Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-i …
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling.
Chiu SC, Tsao SW, Hwang PI, Vanisree S, Chen YA, Yang NS. Chiu SC, et al. BMC Genomics. 2010 Sep 24;11:513. doi: 10.1186/1471-2164-11-513. BMC Genomics. 2010. PMID: 20868472 Free PMC article.
In contrast, neither cytopiloyne nor BF/S+L/Ep inhibited the early expression of these 50 genes, but rather inhibited most late-stage expression (~12 h) of another immune gene subset. TRANSPATH database key node analysis identified the extracellular signal-regulated kinase …
In contrast, neither cytopiloyne nor BF/S+L/Ep inhibited the early expression of these 50 genes, but rather inhibited most late-stage expres …
ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis.
Dos Santos PF, Van Weyenbergh J, Delgobo M, Oliveira Patricio D, Ferguson BJ, Guabiraba R, Dierckx T, Menezes SM, Báfica A, Mansur DS. Dos Santos PF, et al. J Immunol. 2018 Feb 15;200(4):1434-1442. doi: 10.4049/jimmunol.1701120. Epub 2018 Jan 8. J Immunol. 2018. PMID: 29311364 Free article.
IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attributed to its extracellular cytokine-like activity. In this study, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, …
IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attri …
Atlantic salmon ISG15: Expression and conjugation to cellular proteins in response to interferon, double-stranded RNA and virus infections.
Røkenes TP, Larsen R, Robertsen B. Røkenes TP, et al. Mol Immunol. 2007 Feb;44(5):950-9. doi: 10.1016/j.molimm.2006.03.016. Epub 2006 May 11. Mol Immunol. 2007. PMID: 16697044
ISG15 is one of the earliest and most predominant proteins to be induced in mammals following IFN-alpha/beta stimulation, which suggests that it has an important function in the interferon system. Similar to ubiquitin, ISG15 forms covalent conjugates with its tar
ISG15 is one of the earliest and most predominant proteins to be induced in mammals following IFN-alpha/beta stimulation, which suggests tha …