The 5-lipoxygenase promoter is regulated by DNA methylation.
J Biol Chem. 2002.
PMID: 11706027
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The 5-lipoxygenase promoter is regulated by DNA methylation.
J Biol Chem. 2002 Feb 8;277(6):4374-9. doi: 10.1074/jbc.M107665200. Epub 2001 Nov 12.
J Biol Chem. 2002.
PMID: 11706027
Free article.
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO expression is regulated by DNA methylation. ...In reporter gene assays, 1,25-dihydroxyvitamin D(3) and TGFbeta were unable to induce …
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO expression is …
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Aging Cell. 2017 Apr;16(2):273-280. doi: 10.1111/acel.12550. Epub 2016 Nov 29.
Aging Cell. 2017.
PMID: 27896923
Free PMC article.
Elevated levels of homocysteinemia (Hcy), a risk factor for late-onset Alzheimer's disease (AD), have been associated with changes in cell methylation. Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter …
Elevated levels of homocysteinemia (Hcy), a risk factor for late-onset Alzheimer's disease (AD), have been associated with changes in cell …
5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells.
Neuroscience. 2009 Dec 29;164(4):1531-7. doi: 10.1016/j.neuroscience.2009.09.039. Epub 2009 Sep 22.
Neuroscience. 2009.
PMID: 19778587
Free PMC article.
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possible modulators of stem cell differentiation and aging, using primary cultures of mouse CGC (1, 5, 10, 14, 30 days in vitro; DIV), we studied DNA …
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possible mod …
5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice.
Neural Plast. 2009;2009:209596. doi: 10.1155/2009/209596. Epub 2009 Dec 13.
Neural Plast. 2009.
PMID: 20052386
Free PMC article.
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation. We used methylation-sensitive restriction endonucleases (AciI, BstUI, HpaII, and HinP1I) to assess 5-LOX DN …
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA …
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Biochim Biophys Acta. 2010 Jan;1801(1):49-57. doi: 10.1016/j.bbalip.2009.09.003. Epub 2009 Sep 23.
Biochim Biophys Acta. 2010.
PMID: 19781662
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this study we investigated the impact of the DNA methylation status of the 5-LO promoter on its activity and the role of meth …
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this s …
Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation.
J Alzheimers Dis. 2013;37(1):3-8. doi: 10.3233/JAD-130506.
J Alzheimers Dis. 2013.
PMID: 23727898
Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells o …
Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly u …
DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells.
J Neurochem. 2004 Mar;88(6):1424-30. doi: 10.1046/j.1471-4159.2003.02275.x.
J Neurochem. 2004.
PMID: 15009643
DNA methylation in promoter regions is typically associated with gene silencing. We found that human NT2 cells, which differentiate into neuron-like NT2-N cells, express 5-lipoxygenase and we investigated the relationship between 5-lip …
DNA methylation in promoter regions is typically associated with gene silencing. We found that human NT2 cells, which d …
DNA methylation regulates 5-lipoxygenase promoter activity.
Adv Exp Med Biol. 2003;525:169-72. doi: 10.1007/978-1-4419-9194-2_35.
Adv Exp Med Biol. 2003.
PMID: 12751760
No abstract available.
Allele-specific methylation contributed by CpG-SNP is associated with regulation of ALOX5AP gene expression in ischemic stroke.
Neurol Sci. 2018 Oct;39(10):1717-1724. doi: 10.1007/s10072-018-3489-9. Epub 2018 Jul 12.
Neurol Sci. 2018.
PMID: 30003372
Previous studies have shown that CpG-SNPs might have influence on gene function via allele-specific DNA methylation (ASM). However, association study between DNA methylation and the promoter CpG-SNPs in ALOX5AP gene with IS has not been reported …
Previous studies have shown that CpG-SNPs might have influence on gene function via allele-specific DNA methylation (ASM). How …
Functional analysis of 5-lipoxygenase promoter repeat variants.
Hum Mol Genet. 2009 Dec 1;18(23):4521-9. doi: 10.1093/hmg/ddp414. Epub 2009 Aug 28.
Hum Mol Genet. 2009.
PMID: 19717473
Free PMC article.
Clinical Trial.
To more fully characterize these variants, we carried out gene expression and DNA methylation studies in primary leukocytes from healthy individuals carrying various 5-LO promoter alleles. ...Our results demonstrate that, in lymphocytes, the shorter repeat al …
To more fully characterize these variants, we carried out gene expression and DNA methylation studies in primary leukocytes fr …
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