The 5-lipoxygenase promoter is regulated by DNA methylation.
J Biol Chem. 2002.
PMID: 11706027
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The 5-lipoxygenase promoter is regulated by DNA methylation.
J Biol Chem. 2002 Feb 8;277(6):4374-9. doi: 10.1074/jbc.M107665200. Epub 2001 Nov 12.
J Biol Chem. 2002.
PMID: 11706027
Free article.
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO expression is regulated by DNA methylation. ...In reporter gene assays, 1,25-dihydroxyvitamin D(3) and TGFbeta were unable …
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO exp …
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Aging Cell. 2017 Apr;16(2):273-280. doi: 10.1111/acel.12550. Epub 2016 Nov 29.
Aging Cell. 2017.
PMID: 27896923
Free PMC article.
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regulated by methylation. ...Diet- and genetically induced high Hcy resulted in 5LO protein and mRNA upregulation, which was associated …
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regula …
5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice.
Neural Plast. 2009;2009:209596. doi: 10.1155/2009/209596. Epub 2009 Dec 13.
Neural Plast. 2009.
PMID: 20052386
Free PMC article.
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation. ...Aging also increased 5-LOX DNA methylation and this effect was site- (i.e., enzyme) an …
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including …
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Biochim Biophys Acta. 2010 Jan;1801(1):49-57. doi: 10.1016/j.bbalip.2009.09.003. Epub 2009 Sep 23.
Biochim Biophys Acta. 2010.
PMID: 19781662
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this study we investigated the impact of the DNA methylation status of the 5-LO promoter on its activity and the role …
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this s …
5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells.
Neuroscience. 2009 Dec 29;164(4):1531-7. doi: 10.1016/j.neuroscience.2009.09.039. Epub 2009 Sep 22.
Neuroscience. 2009.
PMID: 19778587
Free PMC article.
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possible modulators of stem cell differentiation and aging, using primary cultures of mouse CGC (1, 5, 10, 14, 30 days in vitro; DIV), we …
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possi …
Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation.
J Alzheimers Dis. 2013;37(1):3-8. doi: 10.3233/JAD-130506.
J Alzheimers Dis. 2013.
PMID: 23727898
Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. ...In addition, a consistent reduction in DNA methylation at 5-LOX …
Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of su …
DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells.
J Neurochem. 2004 Mar;88(6):1424-30. doi: 10.1046/j.1471-4159.2003.02275.x.
J Neurochem. 2004.
PMID: 15009643
Free article.
We found that human NT2 cells, which differentiate into neuron-like NT2-N cells, express 5-lipoxygenase and we investigated the relationship between 5-lipoxygenase expression and the methylation state of the 5-lipoxygenase core …
We found that human NT2 cells, which differentiate into neuron-like NT2-N cells, express 5-lipoxygenase and we investigated th …
Functional analysis of 5-lipoxygenase promoter repeat variants.
Hum Mol Genet. 2009 Dec 1;18(23):4521-9. doi: 10.1093/hmg/ddp414. Epub 2009 Aug 28.
Hum Mol Genet. 2009.
PMID: 19717473
Free PMC article.
Clinical Trial.
DNA methylation analysis of four CpG islands in a 1500 bp region encompassing the 5-LO promoter and the first approximately 100 bp of intron 1 revealed relatively low overall DNA methylation across all genotypes and leukocyte populations. …
DNA methylation analysis of four CpG islands in a 1500 bp region encompassing the 5-LO promoter and the first ap …
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
FEBS Lett. 2012 May 7;586(9):1325-9. doi: 10.1016/j.febslet.2012.03.039. Epub 2012 Apr 3.
FEBS Lett. 2012.
PMID: 22616993
Free article.
Here we compared normal and calcified human aortic valve tissue. Calcified tissue exhibited decreased DNA-methylation in the promoter of the gene encoding the proinflammatory enzyme 5-lipoxygenase (5-LO), accompanied by increased 5 …
Here we compared normal and calcified human aortic valve tissue. Calcified tissue exhibited decreased DNA-methylation in the …
Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity.
Biol Chem. 2003 May;384(5):777-85. doi: 10.1515/BC.2003.086.
Biol Chem. 2003.
PMID: 12817474
In order to study the effects of TsA and several structurally related compounds such as MD85, D237 and M232 on 5-LO promoter activity, we have analyzed the response of a 5-lipoxygenase (5-LO) promoter luciferase reporter gene construct to …
In order to study the effects of TsA and several structurally related compounds such as MD85, D237 and M232 on 5-LO promoter a …