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The 5-lipoxygenase promoter is regulated by DNA methylation.
Uhl J, Klan N, Rose M, Entian KD, Werz O, Steinhilber D. Uhl J, et al. J Biol Chem. 2002 Feb 8;277(6):4374-9. doi: 10.1074/jbc.M107665200. Epub 2001 Nov 12. J Biol Chem. 2002. PMID: 11706027 Free article.
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO expression is regulated by DNA methylation. ...In reporter gene assays, 1,25-dihydroxyvitamin D(3) and TGFbeta were unable …
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO exp …
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Praticò D. Li JG, et al. Aging Cell. 2017 Apr;16(2):273-280. doi: 10.1111/acel.12550. Epub 2016 Nov 29. Aging Cell. 2017. PMID: 27896923 Free PMC article.
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regulated by methylation. ...Diet- and genetically induced high Hcy resulted in 5LO protein and mRNA upregulation, which was associated …
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regula
5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice.
Dzitoyeva S, Imbesi M, Ng LW, Manev H. Dzitoyeva S, et al. Neural Plast. 2009;2009:209596. doi: 10.1155/2009/209596. Epub 2009 Dec 13. Neural Plast. 2009. PMID: 20052386 Free PMC article.
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation. ...Aging also increased 5-LOX DNA methylation and this effect was site- (i.e., enzyme) an …
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including …
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Katryniok C, Schnur N, Gillis A, von Knethen A, Sorg BL, Looijenga L, Rådmark O, Steinhilber D. Katryniok C, et al. Biochim Biophys Acta. 2010 Jan;1801(1):49-57. doi: 10.1016/j.bbalip.2009.09.003. Epub 2009 Sep 23. Biochim Biophys Acta. 2010. PMID: 19781662
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this study we investigated the impact of the DNA methylation status of the 5-LO promoter on its activity and the role …
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this s …
5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells.
Imbesi M, Dzitoyeva S, Ng LW, Manev H. Imbesi M, et al. Neuroscience. 2009 Dec 29;164(4):1531-7. doi: 10.1016/j.neuroscience.2009.09.039. Epub 2009 Sep 22. Neuroscience. 2009. PMID: 19778587 Free PMC article.
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possible modulators of stem cell differentiation and aging, using primary cultures of mouse CGC (1, 5, 10, 14, 30 days in vitro; DIV), we …
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possi …
Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation.
Di Francesco A, Arosio B, Gussago C, Dainese E, Mari D, D'Addario C, Maccarrone M. Di Francesco A, et al. J Alzheimers Dis. 2013;37(1):3-8. doi: 10.3233/JAD-130506. J Alzheimers Dis. 2013. PMID: 23727898
Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. ...In addition, a consistent reduction in DNA methylation at 5-LOX …
Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of su …
DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells.
Zhang Z, Chen CQ, Manev H. Zhang Z, et al. J Neurochem. 2004 Mar;88(6):1424-30. doi: 10.1046/j.1471-4159.2003.02275.x. J Neurochem. 2004. PMID: 15009643 Free article.
We found that human NT2 cells, which differentiate into neuron-like NT2-N cells, express 5-lipoxygenase and we investigated the relationship between 5-lipoxygenase expression and the methylation state of the 5-lipoxygenase core …
We found that human NT2 cells, which differentiate into neuron-like NT2-N cells, express 5-lipoxygenase and we investigated th …
Functional analysis of 5-lipoxygenase promoter repeat variants.
Vikman S, Brena RM, Armstrong P, Hartiala J, Stephensen CB, Allayee H. Vikman S, et al. Hum Mol Genet. 2009 Dec 1;18(23):4521-9. doi: 10.1093/hmg/ddp414. Epub 2009 Aug 28. Hum Mol Genet. 2009. PMID: 19717473 Free PMC article. Clinical Trial.
DNA methylation analysis of four CpG islands in a 1500 bp region encompassing the 5-LO promoter and the first approximately 100 bp of intron 1 revealed relatively low overall DNA methylation across all genotypes and leukocyte populations.
DNA methylation analysis of four CpG islands in a 1500 bp region encompassing the 5-LO promoter and the first ap
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
Nagy E, Bäck M. Nagy E, et al. FEBS Lett. 2012 May 7;586(9):1325-9. doi: 10.1016/j.febslet.2012.03.039. Epub 2012 Apr 3. FEBS Lett. 2012. PMID: 22616993 Free article.
Here we compared normal and calcified human aortic valve tissue. Calcified tissue exhibited decreased DNA-methylation in the promoter of the gene encoding the proinflammatory enzyme 5-lipoxygenase (5-LO), accompanied by increased 5
Here we compared normal and calcified human aortic valve tissue. Calcified tissue exhibited decreased DNA-methylation in the …
Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity.
Klan N, Seuter S, Schnur N, Jung M, Steinhilber D. Klan N, et al. Biol Chem. 2003 May;384(5):777-85. doi: 10.1515/BC.2003.086. Biol Chem. 2003. PMID: 12817474
In order to study the effects of TsA and several structurally related compounds such as MD85, D237 and M232 on 5-LO promoter activity, we have analyzed the response of a 5-lipoxygenase (5-LO) promoter luciferase reporter gene construct to …
In order to study the effects of TsA and several structurally related compounds such as MD85, D237 and M232 on 5-LO promoter a …
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