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The 5-lipoxygenase promoter is regulated by DNA methylation.
Uhl J, Klan N, Rose M, Entian KD, Werz O, Steinhilber D. Uhl J, et al. J Biol Chem. 2002 Feb 8;277(6):4374-9. doi: 10.1074/jbc.M107665200. Epub 2001 Nov 12. J Biol Chem. 2002. PMID: 11706027 Free article.
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO expression is regulated by DNA methylation. ...In reporter gene assays, 1,25-dihydroxyvitamin D(3) and TGFbeta were unable …
The mechanisms involved in the regulation of cell type-specific 5-LO expression are unknown. Here we show that 5-LO exp …
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Praticò D. Li JG, et al. Aging Cell. 2017 Apr;16(2):273-280. doi: 10.1111/acel.12550. Epub 2016 Nov 29. Aging Cell. 2017. PMID: 27896923 Free PMC article.
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regulated by methylation. ...Diet- and genetically induced high Hcy resulted in 5LO protein and mRNA upregulation, which was associated …
Alzheimer's disease is characterized by an upregulation of the 5-lipoxygenase (5LO), whose promoter is regula …
5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice.
Dzitoyeva S, Imbesi M, Ng LW, Manev H. Dzitoyeva S, et al. Neural Plast. 2009;2009:209596. doi: 10.1155/2009/209596. Epub 2009 Dec 13. Neural Plast. 2009. PMID: 20052386 Free PMC article.
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation. ...Aging also increased 5-LOX DNA methylation and this effect was site- (i.e., enzyme) an …
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including …
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Katryniok C, Schnur N, Gillis A, von Knethen A, Sorg BL, Looijenga L, Rådmark O, Steinhilber D. Katryniok C, et al. Biochim Biophys Acta. 2010 Jan;1801(1):49-57. doi: 10.1016/j.bbalip.2009.09.003. Epub 2009 Sep 23. Biochim Biophys Acta. 2010. PMID: 19781662
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this study we investigated the impact of the DNA methylation status of the 5-LO promoter on its activity and the role …
It is known that basal 5-lipoxygenase promoter activity is regulated by DNA methylation. In this s …
Epigenetic regulation mechanism of DNA methylation and miRNAs on the expression of the ALOX5AP gene in patients with ischemic stroke.
Bie X, Zhao H, Zhang Z, Wang X, Luan Y, Wang Y, Yang S, Xu L, Zhang X, Zhou B, Dong H, Xu Y, Yang D, Zheng H, He Y. Bie X, et al. Exp Ther Med. 2021 Dec;22(6):1484. doi: 10.3892/etm.2021.10919. Epub 2021 Oct 26. Exp Ther Med. 2021. PMID: 34765025 Free PMC article.
5-lipoxygenase-activating protein (FLAP), encoded by the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene, can adjust the biogenesis of proinflammatory leukotrienes to increase the adhesion and permeability of the vascular internal …
5-lipoxygenase-activating protein (FLAP), encoded by the arachidonate 5-lipoxygenase-activating protein ( …
Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation.
Di Francesco A, Arosio B, Gussago C, Dainese E, Mari D, D'Addario C, Maccarrone M. Di Francesco A, et al. J Alzheimers Dis. 2013;37(1):3-8. doi: 10.3233/JAD-130506. J Alzheimers Dis. 2013. PMID: 23727898
Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. ...In addition, a consistent reduction in DNA methylation at 5-LOX …
Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of su …
5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells.
Imbesi M, Dzitoyeva S, Ng LW, Manev H. Imbesi M, et al. Neuroscience. 2009 Dec 29;164(4):1531-7. doi: 10.1016/j.neuroscience.2009.09.039. Epub 2009 Sep 22. Neuroscience. 2009. PMID: 19778587 Free PMC article.
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possible modulators of stem cell differentiation and aging, using primary cultures of mouse CGC (1, 5, 10, 14, 30 days in vitro; DIV), we …
Since epigenetic mechanisms including DNA methylation regulate 5-LOX expression and have been suggested as possi …
Allele-specific methylation contributed by CpG-SNP is associated with regulation of ALOX5AP gene expression in ischemic stroke.
Shi Y, Xu L, Feng Q, Li A, Jia J, Xu Y, Yang D, Zhang Y, Zhang X, Zhao H, Wang J, He Y, Zheng H. Shi Y, et al. Neurol Sci. 2018 Oct;39(10):1717-1724. doi: 10.1007/s10072-018-3489-9. Epub 2018 Jul 12. Neurol Sci. 2018. PMID: 30003372
Previous studies have shown that CpG-SNPs might have influence on gene function via allele-specific DNA methylation (ASM). However, association study between DNA methylation and the promoter CpG-SNPs in ALOX5AP gene with IS has not been reported …
Previous studies have shown that CpG-SNPs might have influence on gene function via allele-specific DNA methylation (ASM). How …
Functional analysis of 5-lipoxygenase promoter repeat variants.
Vikman S, Brena RM, Armstrong P, Hartiala J, Stephensen CB, Allayee H. Vikman S, et al. Hum Mol Genet. 2009 Dec 1;18(23):4521-9. doi: 10.1093/hmg/ddp414. Epub 2009 Aug 28. Hum Mol Genet. 2009. PMID: 19717473 Free PMC article. Clinical Trial.
DNA methylation analysis of four CpG islands in a 1500 bp region encompassing the 5-LO promoter and the first approximately 100 bp of intron 1 revealed relatively low overall DNA methylation across all genotypes and leukocyte populations. …
DNA methylation analysis of four CpG islands in a 1500 bp region encompassing the 5-LO promoter and the first ap …
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
Nagy E, Bäck M. Nagy E, et al. FEBS Lett. 2012 May 7;586(9):1325-9. doi: 10.1016/j.febslet.2012.03.039. Epub 2012 Apr 3. FEBS Lett. 2012. PMID: 22616993 Free article.
Here we compared normal and calcified human aortic valve tissue. Calcified tissue exhibited decreased DNA-methylation in the promoter of the gene encoding the proinflammatory enzyme 5-lipoxygenase (5-LO), accompanied by increased 5 …
Here we compared normal and calcified human aortic valve tissue. Calcified tissue exhibited decreased DNA-methylation in the …
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