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The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Wacleche VS, et al. Viruses. 2018 Feb 6;10(2):65. doi: 10.3390/v10020065. Viruses. 2018. PMID: 29415518 Free PMC article. Review.
Myeloid cells such as monocytes, dendritic cells (DC) and macrophages (MΦ) are key components of the innate immune system contributing to the maintenance of tissue homeostasis and the development/resolution of immune responses to pathogens. ...T …
Myeloid cells such as monocytes, dendritic cells (DC) and macrophages (MΦ) are key components of the innate immu …
CD16(+) monocytes give rise to CD103(+)RALDH2(+)TCF4(+) dendritic cells with unique transcriptional and immunological features.
Wacleche VS, Cattin A, Goulet JP, Gauchat D, Gosselin A, Cleret-Buhot A, Zhang Y, Tremblay CL, Routy JP, Ancuta P. Wacleche VS, et al. Blood Adv. 2018 Nov 13;2(21):2862-2878. doi: 10.1182/bloodadvances.2018020123. Blood Adv. 2018. PMID: 30381402 Free PMC article.
Classical CD16(-) vs intermediate/nonclassical CD16(+) monocytes differ in their homing potential and biological functions, but whether they differentiate into dendritic cells (DCs) with distinct contributions to immunity against bacterial/viral pathog …
Classical CD16(-) vs intermediate/nonclassical CD16(+) monocytes differ in their homing potential and biological functions, but wheth …
HIV infection of monocytes-derived dendritic cells inhibits Vγ9Vδ2 T cells functions.
Sacchi A, Rinaldi A, Tumino N, Casetti R, Agrati C, Turchi F, Bordoni V, Cimini E, Martini F. Sacchi A, et al. PLoS One. 2014 Oct 23;9(10):e111095. doi: 10.1371/journal.pone.0111095. eCollection 2014. PLoS One. 2014. PMID: 25340508 Free PMC article.
However, whether HIV infection may alter DC-Vγ9Vδ2 T cells cross-talk was not yet described. To clarify this issue, we cultured activated Vγ9Vδ2 T cells with HIV infected monocyte derived DC (MoDC). ...These data indicate that HIV-infecte …
However, whether HIV infection may alter DC-Vγ9Vδ2 T cells cross-talk was not yet described. To clarify this issue, we culture …
HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation.
Masotti A, Donninelli G, Da Sacco L, Varano B, Del Cornò M, Gessani S. Masotti A, et al. BMC Genomics. 2015 Jun 27;16(1):480. doi: 10.1186/s12864-015-1673-3. BMC Genomics. 2015. PMID: 26116514 Free PMC article.
The important role that these molecules play in the pathogenesis of HIV-1 is only now emerging. RESULTS: We provide evidence that exposure of monocyte-derived dendritic cells (MDDCs) to recombinant HIV-1 R5 gp120, but not to CCR5 natural …
The important role that these molecules play in the pathogenesis of HIV-1 is only now emerging. RESULTS: We provide evidence t …
Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.
Conti L, Fantuzzi L, Del Cornò M, Belardelli F, Gessani S. Conti L, et al. Immunobiology. 2004;209(1-2):99-115. doi: 10.1016/j.imbio.2004.02.008. Immunobiology. 2004. PMID: 15481145 Review.
Among APC, monocytes, macrophages and dendritic cells (DC) form the principal non-T cell compartment involved in in vivo HIV infection, and these cells play important and well-established roles in multiple aspects of viral pathogenesis. …
Among APC, monocytes, macrophages and dendritic cells (DC) form the principal non-T cell compartment involved in in viv …
Mycobacteria-infected bystander macrophages trigger maturation of dendritic cells and enhance their ability to mediate HIV transinfection.
Mazurek J, Ignatowicz L, Källenius G, Jansson M, Pawlowski A. Mazurek J, et al. Eur J Immunol. 2012 May;42(5):1192-202. doi: 10.1002/eji.201142049. Eur J Immunol. 2012. PMID: 22539293 Free article.
Mtb, as well as HIV, may modulate the function of many immune cells, including DCs. To dissect the bystander impact of Mφs infected with Mtb on DC functionality, we here investigated changes in DC phenotype, cytokine profiles, and HIV-1 transinfecting ability …
Mtb, as well as HIV, may modulate the function of many immune cells, including DCs. To dissect the bystander impact of Mφs inf …
Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation.
Matassoli FL, Leão IC, Bezerra BB, Pollard RB, Lütjohann D, Hildreth JEK, Arruda LB. Matassoli FL, et al. mSphere. 2018 Nov 7;3(6):e00497-18. doi: 10.1128/mSphere.00497-18. mSphere. 2018. PMID: 30404938 Free PMC article.
The expression of HLA-DR was also reduced in monocytes and dendritic cells treated with HP-BCD, which could hinder T cell activation by these cells. ...Indeed, chronic diseases with inflammatory pathogenesis are being reported as major causes of …
The expression of HLA-DR was also reduced in monocytes and dendritic cells treated with HP-BCD, which could hinder T ce …
miRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP.
Ma L, Shen CJ, Cohen ÉA, Xiong SD, Wang JH. Ma L, et al. PLoS One. 2014 Jun 16;9(6):e99535. doi: 10.1371/journal.pone.0099535. eCollection 2014. PLoS One. 2014. PMID: 24932481 Free PMC article.
Primary monocytes are refractory to HIV-1 infection and become permissive upon differentiation into monocyte-derived dendritic cells (MDDCs) or macrophages. ...Here, we report that the transcript of another cellular factor, VprBP [Vpr (HIV
Primary monocytes are refractory to HIV-1 infection and become permissive upon differentiation into monocyte-derived …
Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment.
van der Sluis RM, van Capel TM, Speijer D, Sanders RW, Berkhout B, de Jong EC, Jeeninga RE, van Montfort T. van der Sluis RM, et al. AIDS. 2015 Jun 1;29(9):1003-14. doi: 10.1097/QAD.0000000000000637. AIDS. 2015. PMID: 25768834
BACKGROUND: Latent HIV type I (HIV-1) infections can frequently occur in short-lived proliferating effector T lymphocytes. These latently infected cells could revert into resting T lymphocytes and thereby contribute to the establishment of the long-liv …
BACKGROUND: Latent HIV type I (HIV-1) infections can frequently occur in short-lived proliferating effector T lymphocytes. The …
Innate immunity in HIV-1 infection: epithelial and non-specific host factors of mucosal immunity- a workshop report.
Nittayananta W, Weinberg A, Malamud D, Moyes D, Webster-Cyriaque J, Ghosh S. Nittayananta W, et al. Oral Dis. 2016 Apr;22 Suppl 1:171-80. doi: 10.1111/odi.12451. Oral Dis. 2016. PMID: 27109285 Review.
The interplay between HIV-1 and epithelial cells represents a critical aspect in mucosal HIV-1 transmission. Epithelial cells lining the oral cavity cover subepithelial tissues, which contain virus-susceptible host cells including CD4(+) T lymph …
The interplay between HIV-1 and epithelial cells represents a critical aspect in mucosal HIV-1 transmission. Epithelial …
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