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Year Number of Results
2000 2
2005 1
2006 2
2007 2
2009 1
2010 2
2011 3
2012 2
2013 6
2014 8
2015 5
2016 6
2017 5
2018 4
2019 6
2020 2
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The CD14+ CD16+ blood monocytes: their role in infection and inflammation.
Ziegler-Heitbrock L. Ziegler-Heitbrock L. J Leukoc Biol. 2007 Mar;81(3):584-92. doi: 10.1189/jlb.0806510. Epub 2006 Nov 29. J Leukoc Biol. 2007. PMID: 17135573 Review.
Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes. ...The current review describes these properties, including the relationship
Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++
Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide.
Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M, Mikolajczyk T, Sliwa T, Dikalov S, Weyand CM, Guzik TJ, Harrison DG. Loperena R, et al. Cardiovasc Res. 2018 Sep 1;114(11):1547-1563. doi: 10.1093/cvr/cvy112. Cardiovasc Res. 2018. PMID: 29800237 Free PMC article.
AIMS: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as classical, intermediate, and non-classical forms. ...Increased endothelial stretch enhanced monocyte conversion to CD14++CD16+ intermediate monoc
AIMS: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as classical, intermediat …
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.
Kelly A, Gunaltay S, McEntee CP, Shuttleworth EE, Smedley C, Houston SA, Fenton TM, Levison S, Mann ER, Travis MA. Kelly A, et al. J Exp Med. 2018 Nov 5;215(11):2725-2736. doi: 10.1084/jem.20171491. Epub 2018 Oct 24. J Exp Med. 2018. PMID: 30355614 Free PMC article.
Here we show that human blood monocytes activate high levels of the cytokine TGFβ, a pathway that is not evident in mouse monocytes. Human CD14(+), but not CD16(+), monocytes activate TGFβ via expression of the integrin αvβ8 and matrix me …
Here we show that human blood monocytes activate high levels of the cytokine TGFβ, a pathway that is not evident in mouse m
Protease-Activated Receptors 1 and 3 are Differentially Expressed on Human Monocyte Subsets and are Upregulated by Lipopolysaccharide Ex Vivo and In Vivo.
Thaler B, Hohensinner PJ, Baumgartner J, Haider P, Krychtiuk KA, Schörgenhofer C, Jilma B, Hell L, Fischer MB, Huber K, Hengstenberg C, Speidl WS, Wojta J. Thaler B, et al. Thromb Haemost. 2019 Sep;119(9):1394-1402. doi: 10.1055/s-0039-1692219. Epub 2019 Jul 10. Thromb Haemost. 2019. PMID: 31291665 Free article.
Monocytes are activated in inflammatory conditions via a variety of cytokine receptors as well as in a procoagulatory setting through thrombin, acting upon protease-activated receptors (PARs). ...CD16(+) monocytes showed significantly higher lev
Monocytes are activated in inflammatory conditions via a variety of cytokine receptors as well as in a procoagulatory setting
Selective expansion of CD16highCCR2- subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation.
Mizuno K, Toma T, Tsukiji H, Okamoto H, Yamazaki H, Ohta K, Ohta K, Kasahara Y, Koizumi S, Yachie A. Mizuno K, et al. Clin Exp Immunol. 2005 Dec;142(3):461-70. doi: 10.1111/j.1365-2249.2005.02932.x. Clin Exp Immunol. 2005. PMID: 16297158 Free PMC article.
Monocytes are composed of two distinct subpopulations in the peripheral blood as determined by their surface antigen expressions, profiles of cytokine production and functional roles played in vivo. ...These results indicate that CD16(high)CCR2(-) subpopulati
Monocytes are composed of two distinct subpopulations in the peripheral blood as determined by their surface antigen expressio
Effects of controlled physical activity on immune cell phenotype in peripheral blood in prehypertension - studies in preclinical model and randomised crossover study.
Mazur M, Glodzik J, Szczepaniak P, Nosalski R, Siedlinski M, Skiba D, Rewiuk K, Salakowski A, Czesnikiewicz-Guzik M, Grodzicki T, Guzik TJ, Mikolajczyk TP. Mazur M, et al. J Physiol Pharmacol. 2018 Dec;69(6). doi: 10.26402/jpp.2018.6.12. Epub 2019 Mar 18. J Physiol Pharmacol. 2018. PMID: 30898984 Free article.
Thus, the aim of this study was to assess the role of moderate regular physical activity on immune cell phenotype. T cell and monocyte subsets were characterised in 31 subjects with prehypertension (130 - 139 mmHg systolic and 85 - 89 mmHg diastolic blood pressure) …
Thus, the aim of this study was to assess the role of moderate regular physical activity on immune cell phenotype. T cell and monocyt …
The absolute number of circulating nonclassical (CD14+CD16++) monocytes negatively correlates with DAS28 and swollen joint count in patients with peripheral spondyloarthritis.
Guła Z, Stec M, Rutkowska-Zapała M, Lenart M, Korkosz M, Gąsowski J, Baran J, Baj-Krzyworzeka M, Szatanek R, Czyż J, Siedlar M. Guła Z, et al. Pol Arch Intern Med. 2017 Dec 22;127(12):846-853. doi: 10.20452/pamw.4142. Epub 2017 Nov 7. Pol Arch Intern Med. 2017. PMID: 29112187 Free article.
Monocytes, as part of the innate immune system, seem to play an important role in the pathogenesis of SpA, but the exact inflammatory pathways remain to be elucidated. ...CONCLUSIONS Nonclassical monocytes may play a role in induction and perpetuati
Monocytes, as part of the innate immune system, seem to play an important role in the pathogenesis of SpA, but the exact infla
TNF-α Inhibitors Decrease Classical CD14(hi)CD16- Monocyte Subsets in Highly Active, Conventional Treatment Refractory Rheumatoid Arthritis and Ankylosing Spondylitis.
Batko B, Schramm-Luc A, Skiba DS, Mikolajczyk TP, Siedlinski M. Batko B, et al. Int J Mol Sci. 2019 Jan 12;20(2):291. doi: 10.3390/ijms20020291. Int J Mol Sci. 2019. PMID: 30642076 Free PMC article.
We observed that treatment with TNFi led to a significant decrease in CD14(hi)CD16- monocytes in comparison to placebo, while circulating CD14(dim)CD16+ monocytes significantly increased. ...The shift towards nonclassical CD14(dim) …
We observed that treatment with TNFi led to a significant decrease in CD14(hi)CD16- monocytes in comparison to placebo, …
Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.
Bartlett DB, Willis LH, Slentz CA, Hoselton A, Kelly L, Huebner JL, Kraus VB, Moss J, Muehlbauer MJ, Spielmann G, Kraus WE, Lord JM, Huffman KM. Bartlett DB, et al. Arthritis Res Ther. 2018 Jun 14;20(1):127. doi: 10.1186/s13075-018-1624-x. Arthritis Res Ther. 2018. PMID: 29898765 Free PMC article. Clinical Trial.
RESULTS: Despite minimal body composition change, cardiorespiratory fitness increased by 9% (change in both relative and absolute aerobic capacity; p < 0.001), and resting blood pressure and heart rate were both reduced (both p < 0.05). ...The frequency of cluster of …
RESULTS: Despite minimal body composition change, cardiorespiratory fitness increased by 9% (change in both relative and absolute aerobic ca …
An unbalanced PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes is correlated with HCV viremia during chronic HCV infection.
Zheng J, Liang H, Xu C, Xu Q, Zhang T, Shen T, Lu F. Zheng J, et al. Cell Mol Immunol. 2014 May;11(3):294-304. doi: 10.1038/cmi.2013.70. Epub 2014 Feb 17. Cell Mol Immunol. 2014. PMID: 24531620 Free PMC article.
PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic HCV infection than in spontaneous HCV resolvers and healthy controls. ...These findings indicates the compromised immune status of the CD14(++)C
PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic HCV infection
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