The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
Proc Natl Acad Sci U S A. 2005.
PMID: 16169901
Free PMC article.
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The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ.
Xia ZB, et al.
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14028-33. doi: 10.1073/pnas.0506464102. Epub 2005 Sep 16.
Proc Natl Acad Sci U S A. 2005.
PMID: 16169901
Free PMC article.
We found that in the MLL-AF4-induced cell lines, the expression of the cyclin-dependent kinase inhibitor gene CDKN1B was dramatically changed at both the RNA and protein (p27kip1) levels. ...MLL-AF4 …
We found that in the MLL-AF4-induced cell lines, the expression of the cyclin-dependent kinase …
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miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221.
Kotani A, Ha D, Hsieh J, Rao PK, Schotte D, den Boer ML, Armstrong SA, Lodish HF.
Kotani A, et al.
Blood. 2009 Nov 5;114(19):4169-78. doi: 10.1182/blood-2008-12-191619. Epub 2009 Sep 11.
Blood. 2009.
PMID: 19749093
Free PMC article.
MLL-AF4 acute lymphocytic leukemia (ALL) has a poor prognosis. MicroRNAs (miRNA) are small noncoding RNAs that posttranscriptionally regulate expression of target mRNAs. ...Reexpression of these miRNAs cooperatively sensitizes 2 cultured lines of ML …
MLL-AF4 acute lymphocytic leukemia (ALL) has a poor prognosis. MicroRNAs (miRNA) are small noncoding RNAs that posttranscripti …
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