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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2005 1
2006 1
2008 1
2009 2
2010 1
2011 3
2012 3
2013 7
2014 6
2015 10
2016 7
2017 8
2018 9
2019 15
2020 7
2021 16
2022 0
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81 results
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Page 1
The Role of Myeloid-Derived Cells in the Progression of Liver Disease.
Weston CJ, Zimmermann HW, Adams DH. Weston CJ, et al. Front Immunol. 2019 Apr 24;10:893. doi: 10.3389/fimmu.2019.00893. eCollection 2019. Front Immunol. 2019. PMID: 31068952 Free PMC article. Review.
A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circulating monocytes, macrophages, dendritic cells and neutrophils control local tissue inflammation and regenerative function to mainta …
A crucial role for myeloid cells during hepatic injury and repair has emerged where resident Kupffer cells, circ …
Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis.
An P, Wei LL, Zhao S, Sverdlov DY, Vaid KA, Miyamoto M, Kuramitsu K, Lai M, Popov YV. An P, et al. Nat Commun. 2020 May 12;11(1):2362. doi: 10.1038/s41467-020-16092-0. Nat Commun. 2020. PMID: 32398673 Free PMC article.
Using liver fibrosis resistant/susceptible mouse strain system, we demonstrate that mito-DAMPs released from injured hepatocyte mitochondria (with mtDNA as major active component) directly activate hepatic stellate cells, the fibrogenic cell in the liver
Using liver fibrosis resistant/susceptible mouse strain system, we demonstrate that mito-DAMPs released from injured hepatocyte mitoc …
PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice.
Kim W, Chu TH, Nienhüser H, Jiang Z, Del Portillo A, Remotti HE, White RA, Hayakawa Y, Tomita H, Fox JG, Drake CG, Wang TC. Kim W, et al. Gastroenterology. 2021 Feb;160(3):781-796. doi: 10.1053/j.gastro.2020.10.036. Epub 2020 Oct 29. Gastroenterology. 2021. PMID: 33129844
We investigated mechanisms of tumor resistance to inhibitors of programmed cell death-1 (PDCD1, also called PD-1) in mice with gastric cancer, and the role of its ligand, PD-L1. ...Expression of PD-L1 by gastric epithelial cells increases tumorigenesis in res …
We investigated mechanisms of tumor resistance to inhibitors of programmed cell death-1 (PDCD1, also called PD-1) in mice with gastri …
Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action.
Xue Y, Gao S, Gou J, Yin T, He H, Wang Y, Zhang Y, Tang X, Wu R. Xue Y, et al. Expert Opin Drug Deliv. 2021 Feb;18(2):187-203. doi: 10.1080/17425247.2021.1825376. Epub 2020 Oct 5. Expert Opin Drug Deliv. 2021. PMID: 32954856 Review.
Furthermore, exploration of the mechanism demonstrates that the combination therapy plays a combination role in two ways. On the one hand, the positive effects of platinum-based chemotherapy on immunomodulation can be harnessed to increase the sensitivity of tumor cells
Furthermore, exploration of the mechanism demonstrates that the combination therapy plays a combination role in two ways. On the one …
Importance of myeloid derived suppressor cells in cancer from a biomarker perspective.
Kalathil SG, Thanavala Y. Kalathil SG, et al. Cell Immunol. 2021 Mar;361:104280. doi: 10.1016/j.cellimm.2020.104280. Epub 2020 Dec 31. Cell Immunol. 2021. PMID: 33445053 Review.
Myeloid derived suppressor cells (MDSC) are a heterogenous population of immature myeloid cells that accumulate in tumor bearing host and migrate to lymphoid organs and tumor tissues. ...Pre-clinical and clinical studies have demonstrated that e
Myeloid derived suppressor cells (MDSC) are a heterogenous population of immature myeloid cells that accu
Eicosanoids in Cancer: Prostaglandin E2 Receptor 4 in Cancer Therapeutics and Immunotherapy.
Ching MM, Reader J, Fulton AM. Ching MM, et al. Front Pharmacol. 2020 May 29;11:819. doi: 10.3389/fphar.2020.00819. eCollection 2020. Front Pharmacol. 2020. PMID: 32547404 Free PMC article. Review.
Resistance to several chemotherapies is reversed in the presence of EP4 antagonists. In addition to tumor cell-autonomous roles of EP4, many EP4-positive host cells play a role in tumor behavior. ...Myeloid-derived suppressor cells (MDSCs …
Resistance to several chemotherapies is reversed in the presence of EP4 antagonists. In addition to tumor cell-autonomous roles of EP …
The innate immune receptor TREM-1 promotes liver injury and fibrosis.
Nguyen-Lefebvre AT, Ajith A, Portik-Dobos V, Horuzsko DD, Arbab AS, Dzutsev A, Sadek R, Trinchieri G, Horuzsko A. Nguyen-Lefebvre AT, et al. J Clin Invest. 2018 Nov 1;128(11):4870-4883. doi: 10.1172/JCI98156. Epub 2018 Oct 2. J Clin Invest. 2018. PMID: 30137027 Free PMC article.
Targeting chronic and uncontrolled inflammation is one strategy to prevent liver injury and fibrosis progression. Here, we demonstrate that triggering receptor expressed on myeloid cells 1 (TREM-1), an amplifier of inflammation, promotes liver
Targeting chronic and uncontrolled inflammation is one strategy to prevent liver injury and fibrosis progression. Here, we dem …
The immunobiology of myeloid-derived suppressor cells in cancer.
Motallebnezhad M, Jadidi-Niaragh F, Qamsari ES, Bagheri S, Gharibi T, Yousefi M. Motallebnezhad M, et al. Tumour Biol. 2016 Feb;37(2):1387-406. doi: 10.1007/s13277-015-4477-9. Epub 2015 Nov 26. Tumour Biol. 2016. PMID: 26611648 Review.
The tumor microenvironment is a complex and heterogeneous milieu in which multiple interactions occur between tumor and host cells. Immunosuppressive cells which are present in this microenvironment, such as regulatory T (Treg) cells and myeloid-der
The tumor microenvironment is a complex and heterogeneous milieu in which multiple interactions occur between tumor and host cells. I …
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. Ma HY, et al. J Hepatol. 2020 May;72(5):946-959. doi: 10.1016/j.jhep.2019.12.016. Epub 2019 Dec 31. J Hepatol. 2020. PMID: 31899206 Free PMC article.
RESULTS: We demonstrate that the global deletion of the Il-17ra gene suppressed HCC in alcohol-fed diethylnitrosamine-challenged Il-17ra(-/-) and major urinary protein-urokinase-type plasminogen activator/Il-17ra(-/-) mice compared with wild-type mice. When the cell-specif …
RESULTS: We demonstrate that the global deletion of the Il-17ra gene suppressed HCC in alcohol-fed diethylnitrosamine-challenged Il-17ra(-/- …
81 results