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The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.
Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, Moreno-Ortíz MC, Martínez-A C, Mellado M. Vila-Coro AJ, et al. FASEB J. 1999 Oct;13(13):1699-710. FASEB J. 1999. PMID: 10506573
We developed a set of monoclonal antibodies that specifically recognize the CXCR4 receptor and used them to identify the signaling pathway activated after SDF-1alpha binding in human T cell lines. ...Furthermore, within seconds of SDF …
We developed a set of monoclonal antibodies that specifically recognize the CXCR4 receptor and used them to identify the signa …
Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation.
Soriano SF, Hernanz-Falcón P, Rodríguez-Frade JM, De Ana AM, Garzón R, Carvalho-Pinto C, Vila-Coro AJ, Zaballos A, Balomenos D, Martínez-A C, Mellado M. Soriano SF, et al. J Exp Med. 2002 Aug 5;196(3):311-21. doi: 10.1084/jem.20012041. J Exp Med. 2002. PMID: 12163560 Free PMC article.
These include genes that encode a family of negative regulators of cytokine signaling, the suppressors of cytokine signaling (SOCS) proteins. After binding their specific receptors, chemokines trigger receptor dimerization and activate th …
These include genes that encode a family of negative regulators of cytokine signaling, the suppressors of cytokine signaling (SOCS) proteins …