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The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2.
Rodríguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martínez-A C, Mellado M. Rodríguez-Frade JM, et al. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3628-33. doi: 10.1073/pnas.96.7.3628. Proc Natl Acad Sci U S A. 1999. PMID: 10097088 Free PMC article.
Cytokines interact with hematopoietin superfamily receptors and stimulate receptor dimerization. We demonstrate that chemoattractant cytokines (chemokines) also trigger biological responses through receptor dimerization. Functio
Cytokines interact with hematopoietin superfamily receptors and stimulate receptor dimerization. We demonstrate that ch …
Tyrosine phosphorylation-mediated signal transduction in MCP-1-induced macrophage activation: role for receptor dimerization, focal adhesion protein complex and JAK/STAT pathway.
Biswas SK, Sodhi A. Biswas SK, et al. Int Immunopharmacol. 2002 Jul;2(8):1095-107. doi: 10.1016/s1567-5769(02)00055-3. Int Immunopharmacol. 2002. PMID: 12349947
Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in the recruitment of monocytes/macrophages associated with several inflammatory diseases and malignancies. ...Present investigations suggest that the early events in the tyrosine kinase s
Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in the recruitment of monocytes/macrophages asso
Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.
Percherancier Y, Berchiche YA, Slight I, Volkmer-Engert R, Tamamura H, Fujii N, Bouvier M, Heveker N. Percherancier Y, et al. J Biol Chem. 2005 Mar 18;280(11):9895-903. doi: 10.1074/jbc.M411151200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632118 Free article.
Using a sensitive bioluminescence resonance energy transfer system, we investigated the formation of CXCR4 and CCR2 chemokine receptor dimers. We found that both receptors exist as constitutive homo- and heterodimers and that ligands induce
Using a sensitive bioluminescence resonance energy transfer system, we investigated the formation of CXCR4 and CCR2 chemokine