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The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
Mellado M, Rodríguez-Frade JM, Aragay A, del Real G, Martín AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martínez-A C. Mellado M, et al. J Immunol. 1998 Jul 15;161(2):805-13. J Immunol. 1998. PMID: 9670957
Using the Mono Mac 1 monocytic cell line, we show that monocyte chemotactic protein 1 (MCP-1) triggers activation of the Janus kinase 2 (JAK2)/STAT3 pathway and CCR2 receptor tyrosine phosphory
Using the Mono Mac 1 monocytic cell line, we show that monocyte chemotactic protein 1 (MCP-1) triggers
The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2.
Rodríguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martínez-A C, Mellado M. Rodríguez-Frade JM, et al. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3628-33. doi: 10.1073/pnas.96.7.3628. Proc Natl Acad Sci U S A. 1999. PMID: 10097088 Free PMC article.
Cytokines interact with hematopoietin superfamily receptors and stimulate receptor dimerization. We demonstrate that chemoattractant cytokines (chemokines) also trigger biological responses through receptor dimerization. ...Monocyte chemoattract …
Cytokines interact with hematopoietin superfamily receptors and stimulate receptor dimerization. We demonstrate that chemoattr …