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Year Number of Results
1994 1
1995 3
1996 3
1997 2
1998 1
1999 1
2000 1
2001 3
2012 1
2013 1
2017 1
2020 0
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The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.
Wegenka UM, Lütticken C, Buschmann J, Yuan J, Lottspeich F, Müller-Esterl W, Schindler C, Roeb E, Heinrich PC, Horn F. Wegenka UM, et al. Mol Cell Biol. 1994 May;14(5):3186-96. doi: 10.1128/mcb.14.5.3186. Mol Cell Biol. 1994. PMID: 8164674 Free PMC article.
We have shown recently that IL-6 and leukemia inhibitory factor rapidly activate a latent cytoplasmic transcription factor, acute-phase response factor (APRF), by tyrosine phosphorylation, which then binds to IL-6
We have shown recently that IL-6 and leukemia inhibitory factor rapidly activate a latent cytoplasmic transcription
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Liu Q, Du Y, Li K, Zhang W, Feng X, Hao J, Li H, Liu S. Liu Q, et al. Mediators Inflamm. 2017;2017:3038514. doi: 10.1155/2017/3038514. Epub 2017 May 24. Mediators Inflamm. 2017. PMID: 28626343 Free PMC article.
OSM is one of the interleukin-6 cytokine family members. In order to clarify the role and mechanism of OSM in LN, mice with LN were treated with anti-OSM antibody or isotype antibody. ...In addition, the signal transducer and activator
OSM is one of the interleukin-6 cytokine family members. In order to clarify the role and mechanism of OSM in LN …
Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges.
Lebel E, Vallières L, Rivest S. Lebel E, et al. Endocrinology. 2000 Oct;141(10):3749-63. doi: 10.1210/endo.141.10.7695. Endocrinology. 2000. PMID: 11014231
Cytokine-inducible proteins named as suppressors of cytokine signaling (SOCS) are rapidly induced by interleukin-6 (IL-6) and other members sharing the gp130 receptor subunit after activation of the Janus kinases (JAK) and the signal
Cytokine-inducible proteins named as suppressors of cytokine signaling (SOCS) are rapidly induced by interleukin-6 (IL- …
Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.
Badache A, Hynes NE. Badache A, et al. Cancer Res. 2001 Jan 1;61(1):383-91. Cancer Res. 2001. PMID: 11196191 Free article.
Interleukin (IL)-6, a multifunctional regulator of immune response, hematopoiesis, and acute phase reactions, has also been shown to regulate cancer cell proliferation. ...In T47D cells, IL-6 stimulated the activation of Janus-a
Interleukin (IL)-6, a multifunctional regulator of immune response, hematopoiesis, and acute phase reacti
STAT3 is required for the gp130-mediated full activation of the c-myc gene.
Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, Hibi M, Hirano T. Kiuchi N, et al. J Exp Med. 1999 Jan 4;189(1):63-73. doi: 10.1084/jem.189.1.63. J Exp Med. 1999. PMID: 9874564 Free PMC article.
The signal transducers and activators of transcription (STAT) family members have been implicated in regulating the growth, differentiation, and death of normal and transformed cells in response to either extracellular stimu …
The signal transducers and activators of transcription (STAT) family members have been impl …
Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon gamma.
Sengupta TK, Chen A, Zhong Z, Darnell JE Jr, Ivashkiv LB. Sengupta TK, et al. J Exp Med. 1995 Mar 1;181(3):1015-25. doi: 10.1084/jem.181.3.1015. J Exp Med. 1995. PMID: 7869026 Free PMC article.
SFs did activate a related signal transducer and activator of transcription (STAT) family factor, termed Stat-SF, which bound specifically to the IFN-gamma response region (GRR), a well-characterized …
SFs did activate a related signal transducer and activator of transcription (STAT) famil
STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6.
Zhang D, Sun M, Samols D, Kushner I. Zhang D, et al. J Biol Chem. 1996 Apr 19;271(16):9503-9. doi: 10.1074/jbc.271.16.9503. J Biol Chem. 1996. PMID: 8621622 Free article.
Interleukin-6 (IL-6) is the major cytokine inducing transcription of human C-reactive protein (CRP) during the acute phase response. STAT (signal transducers and activators of transcription) fa
Interleukin-6 (IL-6) is the major cytokine inducing transcription of human C-reactive protein (CRP) during the
IL-4 inhibits the melanogenesis of normal human melanocytes through the JAK2-STAT6 signaling pathway.
Choi H, Choi H, Han J, Jin SH, Park JY, Shin DW, Lee TR, Kim K, Lee AY, Noh M. Choi H, et al. J Invest Dermatol. 2013 Feb;133(2):528-36. doi: 10.1038/jid.2012.331. Epub 2012 Sep 20. J Invest Dermatol. 2013. PMID: 22992805 Free article.
IL-4 directly inhibited melanogenesis in NHMs and downregulated both transcription and translation of melanogenesis-associated genes, such as microphthalmia-associated transcription factor (MITF) and dopachrome tautomerase. ...IFNγ activated signal
IL-4 directly inhibited melanogenesis in NHMs and downregulated both transcription and translation of melanogenesis-associated genes, …
Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements.
Lai CF, Ripperger J, Morella KK, Jurlander J, Hawley TS, Carson WE, Kordula T, Caligiuri MA, Hawley RG, Fey GH, Baumann H. Lai CF, et al. J Biol Chem. 1996 Jun 14;271(24):13968-75. doi: 10.1074/jbc.271.24.13968. J Biol Chem. 1996. PMID: 8662928 Free article.
The cytoplasmic domain of the receptor for interleukin 10 (IL-10R) contains two box 3 sequence motifs that have been identified in the signal-transducing receptor subunits for IL-6-type cytokines and noted to be required for activating STAT3
The cytoplasmic domain of the receptor for interleukin 10 (IL-10R) contains two box 3 sequence motifs that have been identified in th …
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo.
Hamanaka I, Saito Y, Yasukawa H, Kishimoto I, Kuwahara K, Miyamoto Y, Harada M, Ogawa E, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Masuda I, Yoshimura A, Nakao K. Hamanaka I, et al. Circ Res. 2001 Apr 13;88(7):727-32. doi: 10.1161/hh0701.088512. Circ Res. 2001. PMID: 11304496
CIS (cytokine-inducible SH2 protein), SOCS (suppressor of cytokine signaling), or SSI (signal transducers and activators of transcription [STAT]-induced STAT inhibitor) proteins are a family of cytokine-inducible negative re …
CIS (cytokine-inducible SH2 protein), SOCS (suppressor of cytokine signaling), or SSI (signal transducers and activa
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