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2011 2
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2013 1
2018 1
2020 1
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The role of monocytosis and neutrophilia in atherosclerosis.
Chistiakov DA, Grechko AV, Myasoedova VA, Melnichenko AA, Orekhov AN. Chistiakov DA, et al. J Cell Mol Med. 2018 Mar;22(3):1366-1382. doi: 10.1111/jcmm.13462. Epub 2018 Jan 24. J Cell Mol Med. 2018. PMID: 29364567 Free PMC article. Review.
Monocytosis and neutrophilia are frequent events in atherosclerosis. ...These cells accumulate in the plaques thereby enhancing vascular inflammation and contributing to further lesion progression. Studies in animal models of atherosclerosis showed tha
Monocytosis and neutrophilia are frequent events in atherosclerosis. ...These cells accumulate in the plaques thereby e
Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.
Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR. Westerterp M, et al. Circ Res. 2013 May 24;112(11):1456-65. doi: 10.1161/CIRCRESAHA.113.301086. Epub 2013 Apr 9. Circ Res. 2013. PMID: 23572498 Free PMC article.
OBJECTIVE: To assess the role of macrophage cholesterol efflux pathways in atherogenesis. ...Unexpectedly, Western-type diet-fed MAC-ABC(DKO) BM-transplanted Ldlr(-/-) mice displayed monocytosis and neutrophilia in the absence of hematopoietic stem and multip …
OBJECTIVE: To assess the role of macrophage cholesterol efflux pathways in atherogenesis. ...Unexpectedly, Western-type diet-fed MAC- …
ABC Transporters, Cholesterol Efflux, and Implications for Cardiovascular Diseases.
Wang N, Westerterp M. Wang N, et al. Adv Exp Med Biol. 2020;1276:67-83. doi: 10.1007/978-981-15-6082-8_6. Adv Exp Med Biol. 2020. PMID: 32705595 Review.
Hematopoietic ABCA1 and ABCG1 deficiencies cause marked HSPC expansion and extramedullary hematopoiesis, particularly in hypercholesterolemia, and lead to marked monocytosis and neutrophilia with exacerbated pro-inflammatory responses. All these contribute to ath
Hematopoietic ABCA1 and ABCG1 deficiencies cause marked HSPC expansion and extramedullary hematopoiesis, particularly in hypercholesterolemi …
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice.
Murphy AJ, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo CL, Wang M, Sanson M, Abramowicz S, Welch C, Bochem AE, Kuivenhoven JA, Yvan-Charvet L, Tall AR. Murphy AJ, et al. J Clin Invest. 2011 Oct;121(10):4138-49. doi: 10.1172/JCI57559. J Clin Invest. 2011. PMID: 21968112 Free PMC article.
In Apoe-/- mice fed a chow or Western- type diet, monocytosis and neutrophilia developed in association with the proliferation and expansion of HSPCs in the BM. ...Infusion of reconstituted HDL and LXR activator treatment each reduced HSPC proliferation and monoc
In Apoe-/- mice fed a chow or Western- type diet, monocytosis and neutrophilia developed in association with the proliferation …
Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis.
Tall AR, Yvan-Charvet L, Westerterp M, Murphy AJ. Tall AR, et al. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2547-52. doi: 10.1161/ATVBAHA.112.300134. Arterioscler Thromb Vasc Biol. 2012. PMID: 23077140 Review.
Monocytosis and neutrophilia are well-established risk factors for atherosclerosis and seem to play a causative role in lesion development. ...
Monocytosis and neutrophilia are well-established risk factors for atherosclerosis and seem to play a causative role
Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells.
Murphy AJ, Westerterp M, Yvan-Charvet L, Tall AR. Murphy AJ, et al. Biochim Biophys Acta. 2012 Mar;1821(3):513-21. doi: 10.1016/j.bbalip.2011.08.003. Epub 2011 Aug 16. Biochim Biophys Acta. 2012. PMID: 21864714 Free PMC article. Review.
A major mechanism by which these treatments are thought to delay progression or cause regression of atherosclerosis is by promoting efflux of cholesterol from macrophage foam cells. ...In addition to traditional roles in macrophages, these transporters have been implicated …
A major mechanism by which these treatments are thought to delay progression or cause regression of atherosclerosis is by promoting e …