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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 5
2003 2
2004 1
2005 4
2006 2
2007 3
2008 4
2009 3
2012 3
2013 1
2014 3
2015 5
2016 2
2017 1
2018 2
2019 2
2020 1
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39 results
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Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage.
Song F, Yi Y, Li C, Hu Y, Wang J, Smith DE, Jiang H. Song F, et al. Cell Death Dis. 2018 Jul 10;9(7):770. doi: 10.1038/s41419-018-0809-1. Cell Death Dis. 2018. PMID: 29991810 Free PMC article.
In this study, mouse peritoneal macrophages (PMs), mouse bone marrow-derived macrophages (BMDMs), the human acute monocytic leukemia cell line THP-1 and the human lung epithelial carcinoma cell line A549 were used to investigate the regulatio
In this study, mouse peritoneal macrophages (PMs), mouse bone marrow-derived macrophages (BMDMs), the human acute mo
Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages.
Haehnel V, Schwarzfischer L, Fenton MJ, Rehli M. Haehnel V, et al. J Immunol. 2002 Jun 1;168(11):5629-37. doi: 10.4049/jimmunol.168.11.5629. J Immunol. 2002. PMID: 12023360 Free article.
This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll-like receptor (TLR)2 in human monocytes and macrophages. ...Interestingly, no sequen …
This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor
Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response.
Bösl K, Giambelluca M, Haug M, Bugge M, Espevik T, Kandasamy RK, Bergstrøm B. Bösl K, et al. Front Physiol. 2018 May 29;9:618. doi: 10.3389/fphys.2018.00618. eCollection 2018. Front Physiol. 2018. PMID: 29896111 Free PMC article.
They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate receptors such as Toll-like receptors (TLRs). We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human pri …
They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate recept …
Upregulation of toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-kappa b activation.
Liu Y, Wang Y, Yamakuchi M, Isowaki S, Nagata E, Kanmura Y, Kitajima I, Maruyama I. Liu Y, et al. Infect Immun. 2001 May;69(5):2788-96. doi: 10.1128/IAI.69.5.2788-2796.2001. Infect Immun. 2001. PMID: 11292690 Free PMC article.
However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in response to the two typical bacterial products. We show in the present study that both PGN and a high concentration of LPS increase TLR2 gene
However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in respon …
IkappaBzeta Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae.
Sundaram K, Rahman MA, Mitra S, Knoell DL, Woodiga SA, King SJ, Wewers MD. Sundaram K, et al. PLoS One. 2016 Sep 6;11(9):e0161931. doi: 10.1371/journal.pone.0161931. eCollection 2016. PLoS One. 2016. PMID: 27597997 Free PMC article.
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, encoding the transcription factor IkappaBzeta, are associated with increased susceptibility to invasive pneumococcal disease. We hence …
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, e …
Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin.
Holtman IR, Bsibsi M, Gerritsen WH, Boddeke HW, Eggen BJ, van der Valk P, Kipp M, van Noort JM, Amor S. Holtman IR, et al. Glia. 2017 Mar;65(3):460-473. doi: 10.1002/glia.23104. Epub 2017 Jan 7. Glia. 2017. PMID: 28063173
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14(+) cells. Following systemic administration, HSPB5 acts as a potent inhibitor of neuroinflammation in animal models and reduces lesion develop …
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14(+) …
Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS.
Dueñas AI, Aceves M, Orduña A, Díaz R, Sánchez Crespo M, García-Rodríguez C. Dueñas AI, et al. Int Immunol. 2006 May;18(5):785-95. doi: 10.1093/intimm/dxl015. Epub 2006 Mar 30. Int Immunol. 2006. PMID: 16574669
To address the signaling routes involved in the response of host cells to LPS from F. tularensis live vaccine strain (LVS), experiments were performed in transiently transfected 293 cells. Induction of kappaB-driven transcriptional activity by 2.5 mug ml(-1) F. tula …
To address the signaling routes involved in the response of host cells to LPS from F. tularensis live vaccine strain (LVS), experiments were …
Different Signaling Pathways Define Different Interferon-Stimulated Gene Expression during Mycobacteria Infection in Macrophages.
Zhou X, Yang J, Zhang Z, Zhang L, Zhu B, Lie L, Huang Y, Ma R, Zhou C, Hu S, Wen Q, Ma L. Zhou X, et al. Int J Mol Sci. 2019 Feb 3;20(3):663. doi: 10.3390/ijms20030663. Int J Mol Sci. 2019. PMID: 30717477 Free PMC article.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) represents one of the greatest threats to human health., Interferons (IFNs) in combination with the first-line of anti-TB drugs have been used for treating TB for decades in the clinic, but how Mtb infection r
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) represents one of the greatest threats to human health., Interferons (IF …
Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.
Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. Murphy M, et al. J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16. J Biol Chem. 2015. PMID: 26082489 Free PMC article.
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. ...LPS stimulation increased Pell …
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction …
Vibrio cholerae porin OmpU mediates M1-polarization of macrophages/monocytes via TLR1/TLR2 activation.
Khan J, Sharma PK, Mukhopadhaya A. Khan J, et al. Immunobiology. 2015 Nov;220(11):1199-209. doi: 10.1016/j.imbio.2015.06.009. Epub 2015 Jun 5. Immunobiology. 2015. PMID: 26093918
PAMP-mediated monocyte/macrophage polarization is important during the infection, as pathogen can suppress host immune system by altering the polarization status of the macrophages/monocytes. OmpU, an outer membrane porin protein of Vibrio cholerae, po …
PAMP-mediated monocyte/macrophage polarization is important during the infection, as pathogen can suppress host immune system …
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