Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages.
J Immunol. 2002.
PMID: 12023360
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Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages.
J Immunol. 2002 Jun 1;168(11):5629-37. doi: 10.4049/jimmunol.168.11.5629.
J Immunol. 2002.
PMID: 12023360
Free article.
This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll-like receptor (TLR)2 in human monocytes and macrophages. ...Our findings provide an initial definition of the human …
This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll- …
Gene Silencing of Toll-like Receptor 2 Gene Expression as a Tactic to Control Mycobacterium Tuberculosis and Granuloma Formation.
Arch Razi Inst. 2022 Apr 30;77(2):827-834. doi: 10.22092/ARI.2022.357152.1984. eCollection 2022 Apr.
Arch Razi Inst. 2022.
PMID: 36284966
Free PMC article.
Due to the increasing frequency of antimicrobial treatment resistance and problems in vaccine development, the pathogenesis of TB for its survival and growth is highly dependent on host lipids and stimulated-lipid droplets formation. Toll-like receptor 2 …
Due to the increasing frequency of antimicrobial treatment resistance and problems in vaccine development, the pathogenesis of TB for its su …
Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage.
Cell Death Dis. 2018 Jul 10;9(7):770. doi: 10.1038/s41419-018-0809-1.
Cell Death Dis. 2018.
PMID: 29991810
Free PMC article.
In this study, mouse peritoneal macrophages (PMs), mouse bone marrow-derived macrophages (BMDMs), the human acute monocytic leukemia cell line THP-1 and the human lung epithelial carcinoma cell line A549 were used to investigate the regulatio …
In this study, mouse peritoneal macrophages (PMs), mouse bone marrow-derived macrophages (BMDMs), the human acute mo …
Expression of M-Ficolin in human monocytes and macrophages.
Mol Immunol. 2008 Mar;45(5):1424-30. doi: 10.1016/j.molimm.2007.08.014. Epub 2007 Oct 10.
Mol Immunol. 2008.
PMID: 17928056
Monocyte-derived macrophages generated by in vitro culture for 5 days strongly reduced M-Ficolin mRNA and protein. Mature tissue macrophages from the lung and from breast milk also showed a very low level of M-Ficolin transcripts. ...
Monocyte-derived macrophages generated by in vitro culture for 5 days strongly reduced M-Ficolin mRNA and protein. Mature tiss …
Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.
Cardiovasc Res. 2008 Aug 1;79(3):537-44. doi: 10.1093/cvr/cvn087. Epub 2008 Apr 14.
Cardiovasc Res. 2008.
PMID: 18411230
METHODS AND RESULTS: In TLR2-transfected human embryonic kidney 293 cells and human monocytes, oxidized low-density lipoproteins inhibited nuclear factor (NF)-kappaB-driven transcriptional activity and chemokine gene expression in response to TL …
METHODS AND RESULTS: In TLR2-transfected human embryonic kidney 293 cells and human monocytes, oxidized low-density lip …
Data driven analysis reveals prognostic genes and immunological targets in human sepsis-associated acute kidney injury.
World J Emerg Med. 2024;15(2):91-97. doi: 10.5847/wjem.j.1920-8642.2024.026.
World J Emerg Med. 2024.
PMID: 38476535
Free PMC article.
METHODS: The microarray datasets GSE65682, GSE30718, and GSE174220 were downloaded from the Gene Expression Omnibus (GEO) database. We identified the co-DEGs and constructed a gene co-expression network to screen the hub genes. ...IL32 expression increased si …
METHODS: The microarray datasets GSE65682, GSE30718, and GSE174220 were downloaded from the Gene Expression Omnibus (GEO) database. W …
Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response.
Front Physiol. 2018 May 29;9:618. doi: 10.3389/fphys.2018.00618. eCollection 2018.
Front Physiol. 2018.
PMID: 29896111
Free PMC article.
We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a distinct immune activation profile compared to signaling from either TLR alone. We compare gene signatures induced by either stimulus alone or together an …
We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a distinct immune activ …
Upregulation of toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-kappa b activation.
Infect Immun. 2001 May;69(5):2788-96. doi: 10.1128/IAI.69.5.2788-2796.2001.
Infect Immun. 2001.
PMID: 11292690
Free PMC article.
However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in response to the two typical bacterial products. We show in the present study that both PGN and a high concentration of LPS increase TLR2 gene …
However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in respon …
Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.
J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16.
J Biol Chem. 2015.
PMID: 26082489
Free PMC article.
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. ...LPS stimulation increased Pellino-1 mRNA and protei …
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory c …
Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin.
Glia. 2017 Mar;65(3):460-473. doi: 10.1002/glia.23104. Epub 2017 Jan 7.
Glia. 2017.
PMID: 28063173
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14(+) cells. Following systemic administration, HSPB5 acts as a potent inhibitor of neuroinflammation in animal models and reduces lesion develop …
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14(+) …
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