Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages.
J Immunol. 2002.
PMID: 12023360
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Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages.
J Immunol. 2002 Jun 1;168(11):5629-37. doi: 10.4049/jimmunol.168.11.5629.
J Immunol. 2002.
PMID: 12023360
This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll-like receptor (TLR)2 in human monocytes and macrophages. ...Our findings provide an initial definition of the human …
This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll- …
TLR-2 gene methylation in peripheral blood monocytes from apical periodontitis individuals: A cross-sectional study.
Int Endod J. 2025 Aug;58(8):1172-1183. doi: 10.1111/iej.14255. Epub 2025 May 23.
Int Endod J. 2025.
PMID: 40407270
AIM: Apical periodontitis (AP) is a chronic inflammatory disease arising from the contamination of the root canal system. Epigenetic regulation plays a pivotal role in controlling monocyte/macrophage-mediated local and systemic responses to bacterial challeng …
AIM: Apical periodontitis (AP) is a chronic inflammatory disease arising from the contamination of the root canal system. Epigenetic regu …
Gene Silencing of Toll-like Receptor 2 Gene Expression as a Tactic to Control Mycobacterium Tuberculosis and Granuloma Formation.
Arch Razi Inst. 2022 Apr 30;77(2):827-834. doi: 10.22092/ARI.2022.357152.1984. eCollection 2022 Apr.
Arch Razi Inst. 2022.
PMID: 36284966
Free PMC article.
Due to the increasing frequency of antimicrobial treatment resistance and problems in vaccine development, the pathogenesis of TB for its survival and growth is highly dependent on host lipids and stimulated-lipid droplets formation. Toll-like receptor 2 …
Due to the increasing frequency of antimicrobial treatment resistance and problems in vaccine development, the pathogenesis of TB for its su …
Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage.
Cell Death Dis. 2018 Jul 10;9(7):770. doi: 10.1038/s41419-018-0809-1.
Cell Death Dis. 2018.
PMID: 29991810
Free PMC article.
In this study, mouse peritoneal macrophages (PMs), mouse bone marrow-derived macrophages (BMDMs), the human acute monocytic leukemia cell line THP-1 and the human lung epithelial carcinoma cell line A549 were used to investigate the regulatio …
In this study, mouse peritoneal macrophages (PMs), mouse bone marrow-derived macrophages (BMDMs), the human acute mo …
Upregulation of toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-kappa b activation.
Infect Immun. 2001 May;69(5):2788-96. doi: 10.1128/IAI.69.5.2788-2796.2001.
Infect Immun. 2001.
PMID: 11292690
Free PMC article.
However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in response to the two typical bacterial products. We show in the present study that both PGN and a high concentration of LPS increase TLR2 gene …
However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in respon …
Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.
Cardiovasc Res. 2008 Aug 1;79(3):537-44. doi: 10.1093/cvr/cvn087. Epub 2008 Apr 14.
Cardiovasc Res. 2008.
PMID: 18411230
METHODS AND RESULTS: In TLR2-transfected human embryonic kidney 293 cells and human monocytes, oxidized low-density lipoproteins inhibited nuclear factor (NF)-kappaB-driven transcriptional activity and chemokine gene expression in response to TL …
METHODS AND RESULTS: In TLR2-transfected human embryonic kidney 293 cells and human monocytes, oxidized low-density lip …
Expression of M-Ficolin in human monocytes and macrophages.
Mol Immunol. 2008 Mar;45(5):1424-30. doi: 10.1016/j.molimm.2007.08.014. Epub 2007 Oct 10.
Mol Immunol. 2008.
PMID: 17928056
Monocyte-derived macrophages generated by in vitro culture for 5 days strongly reduced M-Ficolin mRNA and protein. Mature tissue macrophages from the lung and from breast milk also showed a very low level of M-Ficolin transcripts. ...
Monocyte-derived macrophages generated by in vitro culture for 5 days strongly reduced M-Ficolin mRNA and protein. Mature tiss …
Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS.
Int Immunol. 2006 May;18(5):785-95. doi: 10.1093/intimm/dxl015. Epub 2006 Mar 30.
Int Immunol. 2006.
PMID: 16574669
Conversely, TLR2, TLR2/TLR1 or TLR2/TLR6 transfected cells did not show kappaB-driven transcriptional activity in the presence of F. tularensis LPS. In human monocytic cells, F. tularensis LPS activated extracellular signal-regulated kinases and the pr …
Conversely, TLR2, TLR2/TLR1 or TLR2/TLR6 transfected cells did not show kappaB-driven transcriptional activity in the presence of F. …
Aldosterone induces trained immunity: the role of fatty acid synthesis.
Cardiovasc Res. 2020 Feb 1;116(2):317-328. doi: 10.1093/cvr/cvz137.
Cardiovasc Res. 2020.
PMID: 31119285
In this study, we aimed to investigate whether aldosterone can induce trained immunity in primary human monocytes in vitro and explored the underlying mechanism. METHODS AND RESULTS: We exposed human monocytes to aldosterone for 24 h, after which they …
In this study, we aimed to investigate whether aldosterone can induce trained immunity in primary human monocytes in vitro and …
Data driven analysis reveals prognostic genes and immunological targets in human sepsis-associated acute kidney injury.
World J Emerg Med. 2024;15(2):91-97. doi: 10.5847/wjem.j.1920-8642.2024.026.
World J Emerg Med. 2024.
PMID: 38476535
Free PMC article.
METHODS: The microarray datasets GSE65682, GSE30718, and GSE174220 were downloaded from the Gene Expression Omnibus (GEO) database. We identified the co-DEGs and constructed a gene co-expression network to screen the hub genes. ...IL32 expression increased si …
METHODS: The microarray datasets GSE65682, GSE30718, and GSE174220 were downloaded from the Gene Expression Omnibus (GEO) database. W …
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