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Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression.
Sing A, Rost D, Tvardovskaia N, Roggenkamp A, Wiedemann A, Kirschning CJ, Aepfelbacher M, Heesemann J. Sing A, et al. J Exp Med. 2002 Oct 21;196(8):1017-24. doi: 10.1084/jem.20020908. J Exp Med. 2002. PMID: 12391013 Free PMC article.
A characteristic of the three human-pathogenic Yersinia spp. (the plague agent Yersinia pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) is the expression of the virulence (V)-antigen (LcrV). LcrV i …
A characteristic of the three human-pathogenic Yersinia spp. (the plague agent Yersinia pestis and the enteropathogenic Yer …
Yersinia V antigen induces both TLR homo- and heterotolerance in an IL-10-involving manner.
Reithmeier-Rost D, Bierschenk S, Filippova N, Schröder-Braunstein J, Sing A. Reithmeier-Rost D, et al. Cell Immunol. 2004 Sep-Oct;231(1-2):63-74. doi: 10.1016/j.cellimm.2004.12.003. Epub 2005 Jan 7. Cell Immunol. 2004. PMID: 15919371
The virulence antigen (LcrV) of pathogenic yersiniae "silences" macrophages against stimulation with the TLR2-agonist zymosan A in a CD14/TLR2-dependent fashion via IL-10 induction. ...Since LcrV acts as a secreted protein upon macrophages without requiring direct c …
The virulence antigen (LcrV) of pathogenic yersiniae "silences" macrophages against stimulation with the TLR2-agonist zymosan A in a …