Cinnamon extract combined with high-intensity endurance training alleviates metabolic syndrome via non-canonical WNT signaling

Elham Fayaz; Arsalan Damirchi; Nozhat Zebardast; Parvin Babaei

doi:10.1016/j.nut.2019.03.009

Cinnamon extract combined with high-intensity endurance training alleviates metabolic syndrome via non-canonical WNT signaling

Nutrition. 2019 Sep:65:173-178. doi: 10.1016/j.nut.2019.03.009. Epub 2019 Mar 23.

Authors

Elham Fayaz¹, Arsalan Damirchi², Nozhat Zebardast³, Parvin Babaei⁴

Affiliations

¹ Department of Medical Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
² Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran.
³ Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
⁴ Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Department of Medical Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: p_babaei@gums.ac.ir.

PMID: 31170681
DOI: 10.1016/j.nut.2019.03.009

Abstract

Objectives: The incidence of metabolic syndrome (MetS) in menopausal women is one of the main health care concerns. MetS clusters are related to an imbalance in pro- and anti-inflammatory adipokines such as secreted frizzled-related protein 5 (SFRP5) and wingless-type mammary tumor virus integration site family, member 5A (WNT5A). WNT5A induces an inflammatory state to induce insulin resistance and further pathologic consequences. Recent strategies to prevent progression of MetS to diabetes have focused on conservative treatments such as exercise and herbal medicine. The aim of this study was to investigate the mechanistic effects of cotreatment with cinnamon extract and 12-wk high-intensity endurance training on MetS components considering the non-canonical WNT5A signaling.

Method: Thirty-two female ovariectomized Wistar rats were divided into the following four groups (n = 8/group): exercise (Ova+Exe), cinnamon extract (Ova+Cin), exercise with cinnamon extract (Ova+Exe+Cin) and saline (Ova+Sal). One group of rats undergoing surgery without removal of the ovaries was considered as a sham. After 3 mo of experimental intervention, waist circumference, serum concentrations of glucose, insulin, lipid profile, tumor necrosis factor-α, WNT5A, and SFRP5 were measured.

Results: Data showed a significant reduction in serum glucose, low-density lipoprotein, homeostasis model assessment estimate of insulin resistance, and tumor necrosis factor-α, but an increase in SFRP5 level in Ova+Exe, Ova+Cin and Ova +Exe+Cin groups compared with Ova+Sal group (P < 0.05). Serum WNT5A significantly was reduced only in Ova+Exe+Cin group (P = 0.02).

Conclusion: The present study indicated that high-endurance training combined with aqueous cinnamon extract supplementation for 12 wk more efficiently alleviated insulin resistance and metabolic dysfunctions via reduction in noncanonical WNT signaling in ovariectomized rats.

Keywords: Aerobic training; Cinnamon; Inflammation; Metabolic syndrome; SFRP5; WNT5A.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipokines / metabolism
Animals
Cinnamomum zeylanicum*
Disease Models, Animal
Endurance Training / methods*
Female
Humans
Metabolic Syndrome / physiopathology
Metabolic Syndrome / therapy*
Physical Conditioning, Animal / methods
Plant Extracts / pharmacology*
Rats
Rats, Wistar
Wnt Signaling Pathway / drug effects*
Wnt-5a Protein / metabolism

Substances

Adipokines
Plant Extracts
Wnt-5a Protein
secreted frizzled-related protein 5, rat