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Year Number of Results
1954 2
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1957 1
1960 1
1962 1
1964 1
1967 2
1968 1
1970 4
1971 1
1973 1
1974 2
1976 4
1977 3
1978 3
1979 5
1980 4
1981 11
1982 6
1983 11
1984 7
1985 3
1986 10
1987 1
1988 4
1989 2
1990 5
1991 5
1992 4
1993 2
1994 2
1996 3
1997 2
1998 1
1999 1
2000 4
2001 4
2002 1
2003 4
2004 1
2005 4
2006 3
2007 5
2008 7
2009 8
2010 7
2011 4
2012 6
2013 8
2014 16
2015 9
2016 9
2017 3
2018 12
2019 7
2020 4
2021 5
2022 9
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235 results
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Page 1
Grayanotoxin poisoning: 'mad honey disease' and beyond.
Jansen SA, Kleerekooper I, Hofman ZL, Kappen IF, Stary-Weinzinger A, van der Heyden MA. Jansen SA, et al. Cardiovasc Toxicol. 2012 Sep;12(3):208-15. doi: 10.1007/s12012-012-9162-2. Cardiovasc Toxicol. 2012. PMID: 22528814 Free PMC article. Review.
Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins. Consumption of grayanotoxin containing leaves, flowers or secondary products as honey may result in intoxication specifically characterized by dizziness, …
Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins. Consumption of gr …
Grayanotoxin I Intoxication in Pet Pigs.
Pischon H, Petrick A, Müller M, Köster N, Pietsch J, Mundhenk L. Pischon H, et al. Vet Pathol. 2018 Nov;55(6):896-899. doi: 10.1177/0300985818789482. Epub 2018 Aug 2. Vet Pathol. 2018. PMID: 30071802
Contaminated honey is a common cause of grayanotoxin intoxication in humans. Intoxication of animals, especially cattle, is usually due to ingestion of plants of the Ericaceae family, such as Rhododendron. Here, we report the ingestion of Pieris japonica as the cause of …
Contaminated honey is a common cause of grayanotoxin intoxication in humans. Intoxication of animals, especially cattle, is usually d …
The cardiotoxic effects of acute and chronic grayanotoxin-III in rats.
Doǧanyiǧit Z, Kaymak E, Silici S. Doǧanyiǧit Z, et al. Hum Exp Toxicol. 2020 Mar;39(3):374-383. doi: 10.1177/0960327119889668. Epub 2019 Nov 27. Hum Exp Toxicol. 2020. PMID: 31773988
The purpose of this study is to histologically and immunohistochemically determine the changes created by grayanotoxin-III (GTX-III), which is a sodium channel neurotoxin, on heart tissues in different dosages. ...
The purpose of this study is to histologically and immunohistochemically determine the changes created by grayanotoxin-III (GTX-III), …
Clinical review of grayanotoxin/mad honey poisoning past and present.
Gunduz A, Turedi S, Russell RM, Ayaz FA. Gunduz A, et al. Clin Toxicol (Phila). 2008 Jun;46(5):437-42. doi: 10.1080/15563650701666306. Clin Toxicol (Phila). 2008. PMID: 18568799 Review.
Grayanotoxin is a naturally occurring sodium channel toxin which enters the human food supply by honey made from the pollen and nectar of the plant family Ericaceae in which rhododendron is a genus. ...The pathophysiology, signs, symptoms, clinical course, and treatment of …
Grayanotoxin is a naturally occurring sodium channel toxin which enters the human food supply by honey made from the pollen and necta …
Confirmed Grayanotoxin Poisoning with Bradycardia from a Gift of Imported Honey.
DiSalvo P, Khorolsky C, Filigenzi M, Poppenga R, Hoffman RS. DiSalvo P, et al. J Emerg Med. 2022 Jul 21:S0736-4679(22)00320-1. doi: 10.1016/j.jemermed.2022.05.009. Online ahead of print. J Emerg Med. 2022. PMID: 35871991
BACKGROUND: Human grayanotoxin poisoning is distinctly uncommon in North America, as the predominant source of human exposure is honey made by bees pollinating rhododendron species in the Mediterranean. We present a case of confirmed grayanotoxin poisoning from hone …
BACKGROUND: Human grayanotoxin poisoning is distinctly uncommon in North America, as the predominant source of human exposure is hone …
Grayanotoxin (mad honey) - ongoing consumption after poisoning.
Eroğlu SE, Urgan O, Onur OE, Denizbaşı A, Akoğlu H. Eroğlu SE, et al. Balkan Med J. 2013 Sep;30(3):293-5. doi: 10.5152/balkanmedj.2013.8100. Epub 2013 Sep 1. Balkan Med J. 2013. PMID: 25207122 Free PMC article.
This type of honey is known as "mad honey" in Turkey. The toxic ingredient of this honey is called Grayanotoxin I. The consumption of mad honey can cause severe bradycardia, hypotension, dizziness, nausea and vomiting. ...
This type of honey is known as "mad honey" in Turkey. The toxic ingredient of this honey is called Grayanotoxin I. The consumption of …
Acute effects of grayanotoxin in rhododendron honey on kidney functions in rats.
Silici S, Doğan Z, Sahin H, Atayoğlu T, Yakan B. Silici S, et al. Environ Sci Pollut Res Int. 2016 Feb;23(4):3300-9. doi: 10.1007/s11356-015-5534-z. Epub 2015 Oct 21. Environ Sci Pollut Res Int. 2016. PMID: 26490905
The aim of the study is to evaluate the acute biochemical and histological changes in rat kidneys after treatment with grayanotoxin (GTX) of rhododendron honey (RH). A total of 60 Sprague-Dawley female rats were divided into five groups of 12 rats each, one being a control …
The aim of the study is to evaluate the acute biochemical and histological changes in rat kidneys after treatment with grayanotoxin ( …
Grayanotoxin levels in blood, urine and honey and their association with clinical status in patients with mad honey intoxication.
Aygun A, Sahin A, Karaca Y, Turkmen S, Turedi S, Ahn SY, Kim S, Gunduz A. Aygun A, et al. Turk J Emerg Med. 2017 Jun 4;18(1):29-33. doi: 10.1016/j.tjem.2017.05.001. eCollection 2018 Mar. Turk J Emerg Med. 2017. PMID: 29942880 Free PMC article.
Mean GTX I concentration in honeys consumed was 8.73 mug/gr and mean GTX 3 level 27.60 mug/gr. CONCLUSION: This descriptive study is show grayanotoxin levels in body fluids of patients with mad honey intoxication. No association was determined between grayanotoxin l …
Mean GTX I concentration in honeys consumed was 8.73 mug/gr and mean GTX 3 level 27.60 mug/gr. CONCLUSION: This descriptive study is show …
Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice.
Terai T, Osakabe K, Katai M, Sakaguchi K, Narama I, Matsuura T, Katakawa J, Tetsumi T. Terai T, et al. Chem Pharm Bull (Tokyo). 2003 Mar;51(3):351-3. doi: 10.1248/cpb.51.351. Chem Pharm Bull (Tokyo). 2003. PMID: 12612430 Free article.
Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy …
Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin I …
Grayanotoxin poisoning in three goats.
Puschner B, Holstege DM, Lamberski N. Puschner B, et al. J Am Vet Med Assoc. 2001 Feb 15;218(4):573-5, 527-8. doi: 10.2460/javma.2001.218.573. J Am Vet Med Assoc. 2001. PMID: 11229512
The goats were treated with magnesium hydroxide, activated charcoal, and lactated Ringer's solution and recovered within 24 hours. Definitive diagnosis of grayanotoxin exposure was accomplished by use of liquid chromatography-mass spectrometry analysis of urine and fecal s …
The goats were treated with magnesium hydroxide, activated charcoal, and lactated Ringer's solution and recovered within 24 hours. Definitiv …
235 results

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