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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 11
1996 5
1997 1
1998 7
1999 4
2000 7
2001 2
2002 9
2003 11
2004 9
2005 8
2006 3
2007 6
2008 8
2009 16
2010 12
2011 9
2012 14
2013 16
2014 15
2015 16
2016 2
2017 4
2019 3
2020 1
2022 1
2023 1
2024 0

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185 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Efficacy of single-pill combination in uncontrolled essential hypertension: A systematic review and network meta-analysis.
Xie M, Tang T, Liang H. Xie M, et al. Clin Cardiol. 2023 Aug;46(8):886-898. doi: 10.1002/clc.24082. Epub 2023 Jul 11. Clin Cardiol. 2023. PMID: 37432701 Free PMC article. Review.
The results of the network meta-analysis showed that a total of 11 single-pill combination antihypertensive drugs were included, namely: Amlodipine/valsartan, Telmisartan/amlodipine, Losartan/HCTZ, Candesartan/HCTZ, Amlodipine/benazepril, Telmisartan/HCTZ, Valsartan/HCTZ, …
The results of the network meta-analysis showed that a total of 11 single-pill combination antihypertensive drugs were included, namely: Aml …
Losartan with hydrochlorothiazide in the treatment of hypertension.
Schoenberger JA; Losartan Research Group. Schoenberger JA, et al. J Hypertens Suppl. 1995 Jul;13(1):S43-7. J Hypertens Suppl. 1995. PMID: 18800455 Clinical Trial.
The participants were randomly assigned to concomitant therapy once a day with: (1) 50 mg losartan and 6.25 mg hydrochlorothiazide, (2) 50 mg losartan and 12.5 mg hydrochlorothiazide, (3) 50 mg losartan alone, (4) 12.5 mg hydrochlorothiazide …
The participants were randomly assigned to concomitant therapy once a day with: (1) 50 mg losartan and 6.25 mg hydrochlorothiazide …
A comparative study on the effectiveness of losartan/hydrochlorothiazide and telmisartan/hydrochlorothiazide in patients with hypertension.
Hamada T, Kuwabara M, Watanabe A, Mizuta E, Ohtahara A, Omodani H, Watanabe M, Nakamura H, Hirota Y, Miyazaki S, Kato M, Ogino K, Kosaka H, Haruaki N, Taniguchi S, Yamamoto K, Kotake H, Hisatome I. Hamada T, et al. Clin Exp Hypertens. 2014;36(4):251-7. doi: 10.3109/10641963.2013.810228. Epub 2013 Jul 18. Clin Exp Hypertens. 2014. PMID: 23865441 Free article. Clinical Trial.
PURPOSE: Long-term effects of a low-dose hydrochlorothiazide (HCTZ) with losartan (LOS) on uric acid (UA) metabolism as well as glucose metabolism have been studied in hypertensive patients in comparison with those of a low-dose HCTZ with telmisartan (TEL). METHOD: …
PURPOSE: Long-term effects of a low-dose hydrochlorothiazide (HCTZ) with losartan (LOS) on uric acid (UA) metabolism as well a …
Effects of losartan on a background of hydrochlorothiazide in patients with hypertension.
Soffer BA, Wright JT Jr, Pratt JH, Wiens B, Goldberg AI, Sweet CS. Soffer BA, et al. Hypertension. 1995 Jul;26(1):112-7. doi: 10.1161/01.hyp.26.1.112. Hypertension. 1995. PMID: 7607713 Clinical Trial.
The purpose of this multicenter trial was to compare the antihypertensive efficacy and safety of losartan potassium (losartan), a selective angiotensin II receptor antagonist, when added to hydrochlorothiazide in hypertensive patients whose blood pressure was …
The purpose of this multicenter trial was to compare the antihypertensive efficacy and safety of losartan potassium (losartan) …
Pharmacokinetic comparison and bioequivalence evaluation of losartan/ hydrochlorothiazide tablet between Asian Indian and Japanese volunteers.
Kumar S, Monif T, Khuroo A, Reyar S, Jain R, Singla AK, Kurachi K. Kumar S, et al. Int J Clin Pharmacol Ther. 2014 Jan;52(1):39-54. doi: 10.5414/CP201927. Int J Clin Pharmacol Ther. 2014. PMID: 24290414 Clinical Trial.
OBJECTIVES: To demonstrate the bioequivalence between the test and reference formulations of losartan/hydrochlorothiazide 50 + 12.5 mg tablet and evaluate the effect of ethnicity on pharmacokinetics properties of losartan, losartan carboxylic acid and …
OBJECTIVES: To demonstrate the bioequivalence between the test and reference formulations of losartan/hydrochlorothiazide 50 + …
Combination of losartan and hydrochlorothiazide: in vivo bioequivalence.
Koytchev R, Ozalp Y, Erenmemisoglu A, van der Meer MJ, Alpan RS. Koytchev R, et al. Arzneimittelforschung. 2004 Sep;54(9A):611-7. doi: 10.1055/s-0031-1297058. Arzneimittelforschung. 2004. PMID: 15497669 Clinical Trial.
In the second study, i.e. after administration of combined losartan/hydrochlorothiazide formulations, the 90% confidence interval for intra-individual ratios of AUC0-t and Cmax of losartan were between 0.90 and 1.04 (AUC0-t) as well as between 0.86 and 1.20 ( …
In the second study, i.e. after administration of combined losartan/hydrochlorothiazide formulations, the 90% confidence inter …
Which is a better treatment for hypertensive patients with diabetes: a combination of losartan and hydrochlorothiazide or a maximum dose of losartan?
Nishimura H, Shintani M, Maeda K, Otoshi K, Fukuda M, Okuda J, Nishi S, Ohashi S, Kato S, Baba Y; Biriken Study Group. Nishimura H, et al. Clin Exp Hypertens. 2013;35(8):582-8. doi: 10.3109/10641963.2013.776564. Epub 2013 Mar 15. Clin Exp Hypertens. 2013. PMID: 23496265 Free article. Clinical Trial.
BACKGROUND: This 12-month study compared the effects of a combination of losartan 50 mg and hydrochlorothiazide 12.5 mg with a maximum dose of losartan (100 mg) in hypertensive patients with diabetes. ...In patients with hyperuricemia and impaired renal funct …
BACKGROUND: This 12-month study compared the effects of a combination of losartan 50 mg and hydrochlorothiazide 12.5 mg with a …
Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus.
Derosa G, Querci F, Franzetti I, Dario Ragonesi P, D'Angelo A, Maffioli P. Derosa G, et al. Hypertens Res. 2015 Oct;38(10):690-4. doi: 10.1038/hr.2015.57. Epub 2015 May 21. Hypertens Res. 2015. PMID: 25994603 Clinical Trial.
Patients were treated with barnidipine, 20 mg day(-1), in combination with losartan, 100 mg day(-1), or with telmisartan+hydrochlorothiazide, 80/12.5 mg day(-1), for 6 months. ...The BP was reduced in both groups, although the reduction was greater with barnidipine+ …
Patients were treated with barnidipine, 20 mg day(-1), in combination with losartan, 100 mg day(-1), or with telmisartan+hydrochlo …
Absence of a pharmacokinetic interaction between losartan and hydrochlorothiazide.
McCrea JB, Lo MW, Tomasko L, Lin CC, Hsieh JY, Capra NL, Goldberg MR. McCrea JB, et al. J Clin Pharmacol. 1995 Dec;35(12):1200-6. doi: 10.1002/j.1552-4604.1995.tb04047.x. J Clin Pharmacol. 1995. PMID: 8750372 Clinical Trial.
In this open-label, randomized, three-period, crossover study, patients with mild to moderate hypertension received a 12.5-mg tablet of hydrochlorothiazide, a 50-mg losartan tablet, or a combination tablet of 12.5 mg of hydrochlorothiazide and 50 mg of los …
In this open-label, randomized, three-period, crossover study, patients with mild to moderate hypertension received a 12.5-mg tablet of h …
Losartan/hydrochlorothiazide combination vs. high-dose losartan in patients with morning hypertension--a prospective, randomized, open-labeled, parallel-group, multicenter trial.
Ueda T, Kai H, Imaizumi T; MAPPY Study Investigators. Ueda T, et al. Hypertens Res. 2012 Jul;35(7):708-14. doi: 10.1038/hr.2012.27. Epub 2012 Mar 8. Hypertens Res. 2012. PMID: 22399096 Clinical Trial.
We compared the efficacy and safety of a losartan/hydrochlorothiazide (HCTZ) combination and high-dose losartan in patients with morning hypertension. ...Patients were randomly assigned to receive a combination therapy of 50 mg losartan and 12.5 mg HCT …
We compared the efficacy and safety of a losartan/hydrochlorothiazide (HCTZ) combination and high-dose losartan in pati …
185 results