PubMed (OMIM) for id: 462308

Year	Number of Results
1988	1
1993	1
1995	5
1996	6
1997	3
1998	2
1999	2
2000	4
2001	1
2002	5
2003	3
2004	2
2023	0

1

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Beglopoulos V, et al. J Biol Chem. 2004 Nov 5;279(45):46907-14. doi: 10.1074/jbc.M409544200. Epub 2004 Sep 1. J Biol Chem. 2004. PMID: 15345711 Free article.

2

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.

Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J. Saura CA, et al. Neuron. 2004 Apr 8;42(1):23-36. doi: 10.1016/s0896-6273(04)00182-5. Neuron. 2004. PMID: 15066262 Free article.

3

Atypical dementia associated with a novel presenilin-2 mutation.

Binetti G, Signorini S, Squitti R, Alberici A, Benussi L, Cassetta E, Frisoni GB, Barbiero L, Feudatari E, Nicosia F, Testa C, Zanetti O, Gennarelli M, Perani D, Anchisi D, Ghidoni R, Rossini PM. Binetti G, et al. Ann Neurol. 2003 Dec;54(6):832-6. doi: 10.1002/ana.10760. Ann Neurol. 2003. PMID: 14681895

4

A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease.

Ezquerra M, Lleó A, Castellví M, Queralt R, Santacruz P, Pastor P, Molinuevo JL, Blesa R, Oliva R. Ezquerra M, et al. Arch Neurol. 2003 Aug;60(8):1149-51. doi: 10.1001/archneur.60.8.1149. Arch Neurol. 2003. PMID: 12925374

5

The role of presenilin cofactors in the gamma-secretase complex.

Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. Takasugi N, et al. Nature. 2003 Mar 27;422(6930):438-41. doi: 10.1038/nature01506. Epub 2003 Mar 16. Nature. 2003. PMID: 12660785

6

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.

Lee SF, Shah S, Li H, Yu C, Han W, Yu G. Lee SF, et al. J Biol Chem. 2002 Nov 22;277(47):45013-9. doi: 10.1074/jbc.M208164200. Epub 2002 Sep 23. J Biol Chem. 2002. PMID: 12297508 Free article.

7

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C. Steiner H, et al. J Biol Chem. 2002 Oct 18;277(42):39062-5. doi: 10.1074/jbc.C200469200. Epub 2002 Aug 26. J Biol Chem. 2002. PMID: 12198112 Free article.

8

Presenilins are not required for A beta 42 production in the early secretory pathway.

Wilson CA, Doms RW, Zheng H, Lee VM. Wilson CA, et al. Nat Neurosci. 2002 Sep;5(9):849-55. doi: 10.1038/nn898. Nat Neurosci. 2002. PMID: 12145638

9

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. Francis R, et al. Dev Cell. 2002 Jul;3(1):85-97. doi: 10.1016/s1534-5807(02)00189-2. Dev Cell. 2002. PMID: 12110170 Free article.

10

Identification of a novel family of presenilin homologues.

Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE. Ponting CP, et al. Hum Mol Genet. 2002 May 1;11(9):1037-44. doi: 10.1093/hmg/11.9.1037. Hum Mol Genet. 2002. PMID: 11978763

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