PubMed for id: 7415

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1,241 results

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Page 1

Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study.

Almansa-García AC, Armento A, Cao B, Petremann-Dumé AS, Salmaso S, Caliceti P, Henes C, Bolz S, Kilger E, Süsskind D, Ueffing M, Arango-Gonzalez B. Almansa-García AC, et al. BMC Med. 2026 Jan 10;24(1):54. doi: 10.1186/s12916-025-04610-0. BMC Med. 2026. PMID: 41514281 Free PMC article.

Valosin-Containing Protein as a therapeutic target in CAG repeat-driven Spinocerebellar ataxias: Integrative transcriptomic and computational insights.

Singh S, Joshi D, Makani J, Singh S, Yadav J, Chaurasiya S, Mohanty C, Kumar A, Singh R. Singh S, et al. Comput Biol Chem. 2026 Apr;121:108838. doi: 10.1016/j.compbiolchem.2025.108838. Epub 2025 Dec 11. Comput Biol Chem. 2026. PMID: 41435767

Valosin containing protein (VCP/p97) expression in laryngeal squamous cell carcinoma: clinical evaluation and implications for targeted therapy.

Seuthe IMC, Hunsicker-Biederbeck HC, Ruwe M, Knierer J, Ehrke-Schulz E, Erdogan E, Eichhorn S, Park JJ. Seuthe IMC, et al. Pathol Oncol Res. 2025 Nov 21;31:1612202. doi: 10.3389/pore.2025.1612202. eCollection 2025. Pathol Oncol Res. 2025. PMID: 41357812 Free PMC article.

Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes.

Franklin HD, Crerar H, Parnandi N, Lattke M, Majewski S, Clarke BE, Pallikonda H, Howell M, Boulton SJ, Patani R. Franklin HD, et al. Stem Cell Reports. 2026 Jan 13;21(1):102723. doi: 10.1016/j.stemcr.2025.102723. Epub 2025 Dec 4. Stem Cell Reports. 2026. PMID: 41349534 Free PMC article.

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC).

Salinas-Rebolledo C, Blesa J, Valenzuela-Nieto G, Schwefel D, López-González Del Rey N, Méndez-Ruette M, Burkhalter J, Carrazana E, Díaz-Tejeda F, Arias Catalán I, Cappelli Leon C, Salvadores N, Bátiz LF, Jara R, Obeso JA, Chana-Cuevas P, Sapkota GP, Rojas-Fernandez A. Salinas-Rebolledo C, et al. Elife. 2025 Nov 26;14:e101496. doi: 10.7554/eLife.101496. Elife. 2025. PMID: 41294004 Free PMC article.

SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating.

Zou L-K, Bai J-s, Sun R-c, Yang H-f, Wan M-y, Zhao B-q, Sun B-t, Chen J-x, Chen J, Cheng Y, Zhou B. Zou L-K, et al. J Virol. 2025 Dec 23;99(12):e0164825. doi: 10.1128/jvi.01648-25. Epub 2025 Nov 25. J Virol. 2025. PMID: 41288382 Free PMC article.

PLCG2 promotes cell survival and mitophagy of small cell lung cancer via regulating VCP.

Jiang J, Zhu J, Xiao Y, Gan L. Jiang J, et al. Anticancer Drugs. 2026 Jan 1;37(1):40-48. doi: 10.1097/CAD.0000000000001770. Epub 2025 Oct 16. Anticancer Drugs. 2026. PMID: 41176779

A guide to selecting high-performing antibodies for VCP (UniProt ID: P55072) for use in western blot, immunoprecipitation, and immunofluorescence.

Moleón VR, Fotouhi M, Ryan J, Worrall D, Ayoubi R, Francis V, McPherson PS, Laflamme C. Moleón VR, et al. F1000Res. 2025 Sep 9;14:891. doi: 10.12688/f1000research.169502.1. eCollection 2025. F1000Res. 2025. PMID: 41142959 Free PMC article.

A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking.

He W, Damianou A, Vendrell I, Früh K, Yin DI, Brodsky FM, Kessler BM, Brackenridge S, Borrow P, Gillespie GM, McMichael AJ. He W, et al. Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2514956122. doi: 10.1073/pnas.2514956122. Epub 2025 Oct 24. Proc Natl Acad Sci U S A. 2025. PMID: 41134633 Free PMC article.

CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma.

Yang W, Wang S, Ji S, Wang J, Lian S, Li Z, Jansen RA, Wu W, Niu K, Sun Z, Jia Q, Zheng J, Zhu H, Deng X, Wang L, Fan Z, Shi Y, Lieftink C, Guan M, Beijersbergen RL, Qin W, Gao Q, Bernards R, Jin H. Yang W, et al. Proc Natl Acad Sci U S A. 2025 Sep 30;122(39):e2519568122. doi: 10.1073/pnas.2519568122. Epub 2025 Sep 24. Proc Natl Acad Sci U S A. 2025. PMID: 40991439 Free PMC article.

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PubMed for id: 7415

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