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Effects of polyethylene glycol molecular weight and concentration on lactate dehydrogenase activity in solution and after freeze-thawing.

Mi Y, Wood G, Thoma L, Rashed S. Mi Y, et al. PDA J Pharm Sci Technol. 2002 May-Jun;56(3):115-23. PDA J Pharm Sci Technol. 2002. PMID: 12109331

The application and mechanisms of polyethylene glycol 8000 on stabilizing lactate dehydrogenase during lyophilization.

Mi Y, Wood G. Mi Y, et al. PDA J Pharm Sci Technol. 2004 Jul-Aug;58(4):192-202. PDA J Pharm Sci Technol. 2004. PMID: 15368989

Cryoprotection mechanisms of polyethylene glycols on lactate dehydrogenase during freeze-thawing.

Mi Y, Wood G, Thoma L. Mi Y, et al. AAPS J. 2004 Sep 7;6(3):e22. doi: 10.1208/aapsj060322. AAPS J. 2004. PMID: 15760107 Free PMC article.

A comparison between the protection of LDH during freeze-thawing by PEG 6000 and Brij 35 at low concentrations.

Hillgren A, Aldén M. Hillgren A, et al. Int J Pharm. 2002 Sep 5;244(1-2):137-49. doi: 10.1016/s0378-5173(02)00322-8. Int J Pharm. 2002. PMID: 12204573

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies.

Carpenter JF, Prestrelski SJ, Arakawa T. Carpenter JF, et al. Arch Biochem Biophys. 1993 Jun;303(2):456-64. doi: 10.1006/abbi.1993.1309. Arch Biochem Biophys. 1993. PMID: 8512328

Effect of temperature history on the freeze-thawing process and activity of LDH formulations.

Aldén M, Magnusson A. Aldén M, et al. Pharm Res. 1997 Apr;14(4):426-30. doi: 10.1023/a:1012083029205. Pharm Res. 1997. PMID: 9144726

Maltodextrins as lyoprotectants in the lyophilization of a model protein, LDH.

Corveleyn S, Remon JP. Corveleyn S, et al. Pharm Res. 1996 Jan;13(1):146-50. doi: 10.1023/a:1016006106821. Pharm Res. 1996. PMID: 8668665

A beetle antifreeze protein protects lactate dehydrogenase under freeze-thawing.

Rodriguez C, Sajjadi S, Abrol R, Wen X. Rodriguez C, et al. Int J Biol Macromol. 2019 Sep 1;136:1153-1160. doi: 10.1016/j.ijbiomac.2019.06.067. Epub 2019 Jun 19. Int J Biol Macromol. 2019. PMID: 31226372

Stabilizing effect of amphiphilic excipients on the freeze-thawing and freeze-drying of lactate dehydrogenase.

Izutsu K, Yoshioka S, Terao T. Izutsu K, et al. Biotechnol Bioeng. 1994 May;43(11):1102-7. doi: 10.1002/bit.260431114. Biotechnol Bioeng. 1994. PMID: 18615522

Effect of polyols on polyethylene glycol (PEG)-induced precipitation of proteins: Impact on solubility, stability and conformation.

Kumar V, Sharma VK, Kalonia DS. Kumar V, et al. Int J Pharm. 2009 Jan 21;366(1-2):38-43. doi: 10.1016/j.ijpharm.2008.08.037. Epub 2008 Sep 3. Int J Pharm. 2009. PMID: 18809481

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